GR3023745T3 - Fumagillol derivatives - Google Patents
Fumagillol derivativesInfo
- Publication number
- GR3023745T3 GR3023745T3 GR970401389T GR970401389T GR3023745T3 GR 3023745 T3 GR3023745 T3 GR 3023745T3 GR 970401389 T GR970401389 T GR 970401389T GR 970401389 T GR970401389 T GR 970401389T GR 3023745 T3 GR3023745 T3 GR 3023745T3
- Authority
- GR
- Greece
- Prior art keywords
- substituted
- group
- optionally
- carbamoyl
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/28—Ethers with hydroxy compounds containing oxirane rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21928788 | 1988-09-01 | ||
| JP5353789 | 1989-03-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3023745T3 true GR3023745T3 (en) | 1997-09-30 |
Family
ID=26394244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR970401389T GR3023745T3 (en) | 1988-09-01 | 1997-06-11 | Fumagillol derivatives |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5698586A (el) |
| EP (2) | EP0359036B1 (el) |
| KR (1) | KR0138530B1 (el) |
| AT (1) | ATE150750T1 (el) |
| DE (1) | DE68927904T2 (el) |
| ES (1) | ES2099064T3 (el) |
| GR (1) | GR3023745T3 (el) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH26256A (en) * | 1988-08-12 | 1992-04-01 | Fujisawa Pharmaceutical Co | Oxaspiro [2,5] octane derivative |
| US6017954A (en) * | 1989-08-10 | 2000-01-25 | Children's Medical Center Corp. | Method of treating tumors using O-substituted fumagillol derivatives |
| TW282399B (el) * | 1990-05-25 | 1996-08-01 | Takeda Pharm Industry Co Ltd | |
| DE69114782T2 (de) * | 1990-08-08 | 1996-04-18 | Takeda Chemical Industries Ltd | Intravaskulär embolisierendes Mittel mit Gehalt an einem die Angiogenesis hemmenden Stoff. |
| ZA918168B (en) | 1990-10-16 | 1993-04-14 | Takeda Chemical Industries Ltd | Prolonged release preparation and polymers thereof. |
| DE69231457T2 (de) * | 1991-06-21 | 2001-05-23 | Takeda Chemical Industries Ltd | Zyklodextrin-Zusammensetzung enthaltend Fumagillol-Derivate |
| US6476011B1 (en) | 1991-08-28 | 2002-11-05 | Sterix Limited | Methods for introducing an estrogenic compound |
| US6011024A (en) | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
| US6903084B2 (en) | 1991-08-29 | 2005-06-07 | Sterix Limited | Steroid sulphatase inhibitors |
| ATE161716T1 (de) | 1992-08-07 | 1998-01-15 | Takeda Chemical Industries Ltd | Herstellung von mikrokapseln, die wasserlösliche arzneimittel enthalten |
| ATE153854T1 (de) * | 1992-12-16 | 1997-06-15 | Takeda Chemical Industries Ltd | Stabile pharmazeutische zubereitung mit fumagillolderivaten |
| US5290887A (en) * | 1993-04-30 | 1994-03-01 | The Dow Chemical Company | Epoxy resins containing thiadiazole and/or oxadiazole moieties |
| US5387657A (en) * | 1993-09-10 | 1995-02-07 | The Dow Chemical Company | Epoxy resins containing thiadiazole and/or oxadiazole moieties |
| US6117455A (en) * | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
| WO1996010397A1 (en) * | 1994-09-30 | 1996-04-11 | Takeda Chemical Industries, Ltd. | Oral sustained-release preparation |
| US5710148A (en) * | 1995-03-06 | 1998-01-20 | Senju Pharmaceuticals Co., Ltd. | Corneal opacification inhibitory composition |
| US5837281A (en) | 1995-03-17 | 1998-11-17 | Takeda Chemical Industries, Ltd. | Stabilized interface for iontophoresis |
| CN1095681C (zh) * | 1996-06-20 | 2002-12-11 | 久光制药株式会社 | 一种用于离子电渗疗法的装置结构 |
| CA2210600A1 (en) * | 1996-07-17 | 1998-01-17 | Takashi Houkan | Inhibitor of tumor metastasis or recurrence |
| US5801012A (en) | 1996-09-17 | 1998-09-01 | Northwestern University | Methods and compositions for generating angiostatin |
| AU6578298A (en) | 1997-03-21 | 1998-10-20 | President And Fellows Of Harvard College | Antisense inhibition of angiogenin expression |
| WO1998056372A1 (en) * | 1997-06-09 | 1998-12-17 | Massachusetts Institute Of Technology | TYPE 2 METHIONINE AMINOPEPTIDASE (MetAP2) INHIBITORS AND USES THEROF |
| US6482802B1 (en) | 1998-05-11 | 2002-11-19 | Endowment For Research In Human Biology, Inc. | Use of neomycin for treating angiogenesis-related diseases |
| WO1999061432A1 (en) * | 1998-05-12 | 1999-12-02 | Biochem Pharma Inc. | Fumagillin analogs and their use as angiogenesis inhibitors |
| US8197430B1 (en) | 1998-05-22 | 2012-06-12 | Biopheresis Technologies, Inc. | Method and system to remove cytokine inhibitor in patients |
| US6620382B1 (en) | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
| US6537554B1 (en) | 1998-09-10 | 2003-03-25 | Curagen Corporation | Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis |
| WO2000018232A1 (en) * | 1998-10-01 | 2000-04-06 | Children's Medical Center Corporation | Method of treatment of cardiovascular injuries |
| JP4414517B2 (ja) | 1999-09-01 | 2010-02-10 | 久光製薬株式会社 | イオントフォレーシス用デバイス構造体 |
| EP1227843B1 (en) | 1999-11-10 | 2009-10-14 | BioPheresis Technologies, Inc. | Method and system to remove cytokine inhibitor in patients |
| US6379708B1 (en) * | 1999-11-20 | 2002-04-30 | Cytologic, Llc | Method for enhancing immune responses in mammals |
| US7335650B2 (en) | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
| US20030104573A1 (en) * | 2000-09-11 | 2003-06-05 | Shimkets Richard A. | Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis |
| US7105482B2 (en) | 2000-11-01 | 2006-09-12 | Praecis Pharmaceuticals, Inc. | Methionine aminopeptidase-2 inhibitors and methods of use thereof |
| US6548477B1 (en) | 2000-11-01 | 2003-04-15 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| US6919307B2 (en) | 2000-11-01 | 2005-07-19 | Praecis Pharmaceuticals, Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| PL366216A1 (en) | 2000-11-01 | 2005-01-24 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| EP1436286B1 (en) * | 2001-09-27 | 2009-08-19 | Equispharm Co., Ltd. | Fumagillol derivatives and preparing method thereof |
| US6803382B2 (en) | 2001-11-09 | 2004-10-12 | Galderma Research & Development, S.N.C. | Angiogenesis inhibitors and pharmaceutical and cosmetic use thereof |
| FR2832149B1 (fr) * | 2001-11-09 | 2006-01-06 | Galderma Res & Dev | Nouveaux inhibiteurs de l'angiogenese et leur utilisation pharmaceutique et cosmetique |
| JP2006506321A (ja) * | 2002-04-11 | 2006-02-23 | チルドレンズ メディカル センター コーポレーション | 血管透過性亢進を阻害する方法 |
| WO2003086382A1 (en) * | 2002-04-11 | 2003-10-23 | Children's Medical Center Corporation | Tnp-470 polymer conjugates and use thereof |
| WO2004037164A2 (en) * | 2002-06-21 | 2004-05-06 | University Of Utah Research Foundation | Crosslinked compounds and methods of making and using thereof |
| US8324184B2 (en) | 2003-05-15 | 2012-12-04 | University Of Utah Research Foundation | Anti-adhesion composites and methods of use thereof |
| JP4993465B2 (ja) | 2003-12-04 | 2012-08-08 | ユニバーシティ オブ ユタ リサーチ ファウンデーション | 変性された高分子ならびにその製造方法および使用方法 |
| US20100330143A1 (en) | 2003-12-04 | 2010-12-30 | University Of Utah Research Foundation | Modified macromolecules and methods of making and using thereof |
| EP1699812A2 (en) * | 2003-12-29 | 2006-09-13 | Praecis Pharmaceuticals Inc. | Inhibitors of methionine aminopeptidase-2 and uses thereof |
| KR100552043B1 (ko) * | 2004-02-28 | 2006-02-20 | 주식회사종근당 | 푸마질롤 유도체를 포함하는 비만치료용 조성물 |
| CA2570884C (en) | 2004-06-16 | 2016-04-19 | Jack Arbiser | Carbazole formulations for the treatment of psoriasis and angiogenesis |
| US20080248030A1 (en) * | 2005-02-02 | 2008-10-09 | Children's Medical Center Corporation | Method of Treating Angiogenic Diseases |
| US20070065514A1 (en) | 2005-09-22 | 2007-03-22 | Howell Mark D | Method for enhancing immune responses in mammals |
| AU2007240613B2 (en) * | 2006-04-20 | 2013-11-28 | University Of Utah Research Foundation | Polymeric compositions and methods of making and using thereof |
| US8747870B2 (en) | 2006-04-20 | 2014-06-10 | University Of Utah Research Foundation | Polymeric compositions and methods of making and using thereof |
| WO2008008859A2 (en) * | 2006-07-11 | 2008-01-17 | University Of Utah Research Foundation | Macromolecules modified with electrophilic groups and methods of making and using thereof |
| US20080075690A1 (en) * | 2006-09-22 | 2008-03-27 | Mark Douglas Howell | Method for enhancing immune responses in mammals |
| JP5557746B2 (ja) * | 2007-11-28 | 2014-07-23 | メルサナ セラピューティックス，インク． | 生体適合性生分解性フマギリンアナログ複合体 |
| US8865746B2 (en) | 2008-07-18 | 2014-10-21 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
| US8642650B2 (en) | 2008-12-04 | 2014-02-04 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
| WO2010065877A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
| CN102639494B (zh) | 2009-10-09 | 2016-11-09 | 扎夫根公司 | 砜化合物及其制备和使用方法 |
| KR20110039842A (ko) * | 2009-10-12 | 2011-04-20 | 주식회사 바이오씨에스 | 이미다졸 화합물을 유효성분으로 포함하는 안구의 혈관 신생 관련 질환의 예방 및 치료용 조성물 |
| KR101696960B1 (ko) | 2010-01-08 | 2017-01-16 | 자프겐 인크. | 푸마길롤 타입 화합물 및 그의 제조 및 사용 방법 |
| WO2011085198A1 (en) | 2010-01-08 | 2011-07-14 | Zafgen Corporation | Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph) |
| US20130023513A1 (en) | 2010-01-12 | 2013-01-24 | Hughes Thomas E | Methods and Compositions for Treating Cardiovascular Disorders |
| US20130266578A1 (en) | 2010-04-07 | 2013-10-10 | Thomas E. Hughes | Methods of treating an overweight subject |
| WO2012012642A1 (en) | 2010-07-22 | 2012-01-26 | Zafgen Corporation | Tricyclic compounds and methds of making and using same |
| CN103347870A (zh) | 2010-11-09 | 2013-10-09 | 扎夫根股份有限公司 | Metap-2抑制剂的结晶固体及其制备和使用方法 |
| US20140073691A1 (en) | 2010-11-10 | 2014-03-13 | Zafgen, Inc. | Methods and composition for Treating Thyroid Hormone Related Disorders |
| WO2012074968A1 (en) | 2010-11-29 | 2012-06-07 | Zafgen Corporation | Methods of reducing risk of hepatobiliary dysfunction during rapid weight loss with metap-2 inhibitors |
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| WO2013010045A1 (en) | 2011-07-12 | 2013-01-17 | Biotime Inc. | Novel methods and formulations for orthopedic cell therapy |
| EP2763671A2 (en) | 2011-10-03 | 2014-08-13 | Zafgen, Inc. | Methods of treating age related disorders |
| JP6035347B2 (ja) | 2012-01-18 | 2016-11-30 | ザフゲン，インコーポレイテッド | 三環式スルホンアミド化合物ならびにその作製および使用方法 |
| BR112014017780A8 (pt) | 2012-01-18 | 2017-07-11 | Zafgen Inc | Compostos de sulfona tricíclicos e métodos para fazer e usar os mesmos |
| MX2014013525A (es) | 2012-05-07 | 2015-10-22 | Zafgen Inc | Sal polimorfica de la sal de oxalato de 6-o-(4-dimetilaminoetoxi)c inamoil fumagilol y metodos para elaborarla y utilizarla. |
| CN104363905A (zh) | 2012-05-08 | 2015-02-18 | 扎夫根股份有限公司 | 用metap2抑制剂治疗下丘脑性肥胖 |
| KR20150016534A (ko) | 2012-05-09 | 2015-02-12 | 자프겐 인크. | 푸마지롤형 화합물 및 이의 제조 및 사용 방법 |
| US9561209B2 (en) | 2012-11-05 | 2017-02-07 | Zafgen, Inc. | Methods of treating liver diseases |
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| AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI830078L (fi) | 1982-01-15 | 1983-07-16 | Lilly Co Eli | Askorbinsyraetrar och liknande foereningar |
| JPH0629278B2 (ja) * | 1985-06-26 | 1994-04-20 | 藤沢薬品工業株式会社 | オキサスピロオクタン化合物 |
| JP2544136B2 (ja) | 1986-05-23 | 1996-10-16 | 第一製薬株式会社 | 硫酸化多糖体ｄｓ４１５２を含有する血管新生抑制剤及び抗腫瘍剤 |
| JP2806454B2 (ja) * | 1988-01-19 | 1998-09-30 | 武田薬品工業株式会社 | 脈管形成阻止剤 |
| US5135919A (en) * | 1988-01-19 | 1992-08-04 | Children's Medical Center Corporation | Method and a pharmaceutical composition for the inhibition of angiogenesis |
| US4954496A (en) * | 1988-08-12 | 1990-09-04 | Fujisawa Pharmaceutical Company, Ltd. | Cyclohexane derivatives and pharmaceutical compositions |
| PH26256A (en) * | 1988-08-12 | 1992-04-01 | Fujisawa Pharmaceutical Co | Oxaspiro [2,5] octane derivative |
| ES2053890T3 (es) * | 1988-09-01 | 1994-08-01 | Takeda Chemical Industries Ltd | Agente inhibidor de la angiogenesis. |
-
1989
- 1989-08-31 DE DE68927904T patent/DE68927904T2/de not_active Expired - Lifetime
- 1989-08-31 AT AT89116052T patent/ATE150750T1/de not_active IP Right Cessation
- 1989-08-31 ES ES89116052T patent/ES2099064T3/es not_active Expired - Lifetime
- 1989-08-31 EP EP89116052A patent/EP0359036B1/en not_active Expired - Lifetime
- 1989-08-31 EP EP95112110A patent/EP0682020A1/en not_active Withdrawn
- 1989-08-31 KR KR1019890012548A patent/KR0138530B1/ko not_active IP Right Cessation
-
1992
- 1992-07-21 US US07/917,842 patent/US5698586A/en not_active Expired - Lifetime
-
1997
- 1997-06-11 GR GR970401389T patent/GR3023745T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2099064T3 (es) | 1997-05-16 |
| EP0682020A1 (en) | 1995-11-15 |
| EP0359036A1 (en) | 1990-03-21 |
| ATE150750T1 (de) | 1997-04-15 |
| KR900004722A (ko) | 1990-04-12 |
| KR0138530B1 (ko) | 1998-05-15 |
| EP0359036B1 (en) | 1997-03-26 |
| US5698586A (en) | 1997-12-16 |
| DE68927904T2 (de) | 1997-09-04 |
| DE68927904D1 (de) | 1997-04-30 |
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