GR25080B - METHOD FOR THE PREPARATION OF 1, 1-DIOXIDES OF SULFAMYL-3, 4 DIHYDRO-1, 2, 4-BENZOTHIADIAZINE. - Google Patents
METHOD FOR THE PREPARATION OF 1, 1-DIOXIDES OF SULFAMYL-3, 4 DIHYDRO-1, 2, 4-BENZOTHIADIAZINE.Info
- Publication number
- GR25080B GR25080B GR590125080A GR590125080A GR25080B GR 25080 B GR25080 B GR 25080B GR 590125080 A GR590125080 A GR 590125080A GR 590125080 A GR590125080 A GR 590125080A GR 25080 B GR25080 B GR 25080B
- Authority
- GR
- Greece
- Prior art keywords
- salts
- formula
- benzothiadiazine
- dihydro
- preparation
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
έθοδος παρασκευής, 1,1-διοξειδίων της 3,4-διϋδρο-1,2 βενζοθειαδιαζίνης του γενικού τύπου: [*] και των αλάτων αυτών, ένθα τα R1, R2 και R4 σημαίνουν υδρογόνον ή αλκυλυπόλοιπα, το R3 σημαίνει μη υποκατεστημένα ή υποκατεστημένα υπόλοιπα αλειφατικών υδρογονανθράκων, εστερειωμένας ή αιθεριωμένας υδροξυλομάδας ή άτομα αλογονατόμων, χαρακτηριζομένη κατά τούτο, ότι εν 1-αμινο-βενζολο-2,4-δισουλφοαλογονίδιον του τύπου: [*] ή εν των αλάτων του, ένθα τα R2και R3 έχουν την ανωτέρω δοθείσαν σημασίαν και Hal σημαίνει άτομον αλογόνου, φέρομεν εις αντίδρασινμετά μιας φορμαλδεϋδης ή ενός αποδίδοντος φορμαλδεϋδην μέσου, παρουσία ενός υδραλογονικού οξέος καιακολούθως μετά τινος ενώσες του τύπου NH2-R1, ένθα το R1, έχει την ανωτέρω δοθείσαν σημασίαν, τας δε ληφθείσας ενώσεις κατεργαζόμεθα μετά δυναμένων να υποκαθίστανται ατόμων αζώτου, εάν το επιθυμούμεν, μετά μέσων εισαγόντων εν αλκυλυπόλοιπον και η μετατρέπομεν τα λαμβανόμενα άλατα εις τας ελευθέρας ενώσεις ή μεταβάλλομεν τας λαμβανομένας ελευθέρας ενώσεις εις τα άλατά των. Method of preparation of the 1,1-dihydro-1,2-benzothiadiazine 1,1-dioxide of general formula: [*] and of these salts, wherein R1, R2 and R4 mean hydrogen or alkyl residues, R3 means unsubstituted or substituted aliphatic hydrocarbon residues, sterilized or etherealized hydroxyl group or halide atoms, characterized by 2, 4-disulfo halide of the formula: [*] or in its salts, wherein R2 and R3 have the meaning given above, and Hal means a halogen atom, reacting with a formaldehyde or a formaldehyde yielding agent, in the presence of a hydraulic acid followed by a compound of formula NH2, R1. has the importance given above, and the obtained compounds are then processed to be substituted by nitrogen atoms, if desired, by means of means introduced into alkyl residue and the resulting salts converted to the free compounds or converted to the free ones.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR590125080A GR25080B (en) | 1959-07-28 | 1959-07-28 | METHOD FOR THE PREPARATION OF 1, 1-DIOXIDES OF SULFAMYL-3, 4 DIHYDRO-1, 2, 4-BENZOTHIADIAZINE. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR590125080A GR25080B (en) | 1959-07-28 | 1959-07-28 | METHOD FOR THE PREPARATION OF 1, 1-DIOXIDES OF SULFAMYL-3, 4 DIHYDRO-1, 2, 4-BENZOTHIADIAZINE. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR25080B true GR25080B (en) | 1963-10-03 |
Family
ID=36864909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR590125080A GR25080B (en) | 1959-07-28 | 1959-07-28 | METHOD FOR THE PREPARATION OF 1, 1-DIOXIDES OF SULFAMYL-3, 4 DIHYDRO-1, 2, 4-BENZOTHIADIAZINE. |
Country Status (1)
| Country | Link |
|---|---|
| GR (1) | GR25080B (en) |
-
1959
- 1959-07-28 GR GR590125080A patent/GR25080B/en unknown
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