GB1056833A - Urea derivatives - Google Patents

Urea derivatives

Info

Publication number
GB1056833A
GB1056833A GB24116/63A GB2411663A GB1056833A GB 1056833 A GB1056833 A GB 1056833A GB 24116/63 A GB24116/63 A GB 24116/63A GB 2411663 A GB2411663 A GB 2411663A GB 1056833 A GB1056833 A GB 1056833A
Authority
GB
United Kingdom
Prior art keywords
difluorophenyl
reaction
compounds
urea derivatives
aralkylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24116/63A
Inventor
Albert Lawrence Green
George Lawrence Willey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Priority to GB24116/63A priority Critical patent/GB1056833A/en
Priority to DES91403A priority patent/DE1286009B/en
Priority to US375332A priority patent/US3316151A/en
Publication of GB1056833A publication Critical patent/GB1056833A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of formula <FORM:1056833/C2/1> wherein R1 and R2 are halogen atoms or alkyl groups having up to 4 carbon atoms, and n is 2 or 3, and their preparation by reaction of the corresponding aralkylamine with a metal cyanate in the presence of water. 2 - (21, 61 - Difluorophenyl) - ethylamine and its hydrochloride are prepared by reaction of 2,6-difluorobenzaldehyde with nitromethane to give 2-(21,61-difluorophenyl)-nitrostyrene, reducing this with lithium aluminium hydride, and treating with hydrochloric acid. The compounds of the invention have tranquillizing activity and may be used in pharmaceutical compositions in combination with a carrier, for example in forms suitable for oral administration.
GB24116/63A 1963-06-17 1963-06-17 Urea derivatives Expired GB1056833A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB24116/63A GB1056833A (en) 1963-06-17 1963-06-17 Urea derivatives
DES91403A DE1286009B (en) 1963-06-17 1964-06-05 Monosubstituted urea compounds and processes for their preparation
US375332A US3316151A (en) 1963-06-17 1964-06-15 Methods and compositions for inducing tranquilizing, muscle relaxant and depressant activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB24116/63A GB1056833A (en) 1963-06-17 1963-06-17 Urea derivatives

Publications (1)

Publication Number Publication Date
GB1056833A true GB1056833A (en) 1967-02-01

Family

ID=10206646

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24116/63A Expired GB1056833A (en) 1963-06-17 1963-06-17 Urea derivatives

Country Status (3)

Country Link
US (1) US3316151A (en)
DE (1) DE1286009B (en)
GB (1) GB1056833A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860723A (en) * 1972-02-09 1975-01-14 Smithkline Corp Methods and compositions for increasing feed intake of animals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB573509A (en) * 1943-08-23 1945-11-23 Wellcome Found Urea derivatives
US3090810A (en) * 1961-01-11 1963-05-21 Baxter Laboratories Inc Benzyl thioureas
US3164632A (en) * 1963-02-04 1965-01-05 Baxter Laboratories Inc Benzyl ureas

Also Published As

Publication number Publication date
US3316151A (en) 1967-04-25
DE1286009B (en) 1969-01-02

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