GR22772B - METHOD FOR THE PREPARATION OF 3 - KINAZOLINE OXIES. - Google Patents

METHOD FOR THE PREPARATION OF 3 - KINAZOLINE OXIES.

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Publication number
GR22772B
GR22772B GR590122772A GR590122772A GR22772B GR 22772 B GR22772 B GR 22772B GR 590122772 A GR590122772 A GR 590122772A GR 590122772 A GR590122772 A GR 590122772A GR 22772 B GR22772 B GR 22772B
Authority
GR
Greece
Prior art keywords
preparation
halogen
kinazoline
oxies
stands
Prior art date
Application number
GR590122772A
Other languages
Greek (el)
Original Assignee
F. Hoffmann - La Roche & Co. Aktiengesellschat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche & Co. Aktiengesellschat filed Critical F. Hoffmann - La Roche & Co. Aktiengesellschat
Priority to GR590122772A priority Critical patent/GR22772B/en
Publication of GR22772B publication Critical patent/GR22772B/en

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Abstract

έθοδος δια την παρασκευήν 3-οξειδίων της κιναζολίνηςτου γενικού τύπου (Ι) είς τον οποίον το R1 σημαίνει υδρογόνον ή αλκύλιον, το R2 σημαίνει φαινύλιον,δια της νιτροομάδος ή αλογόνου υποκατεστημένον φαινύλιον ή αλκοξυφαινύλιον, τα R3 και R4 σημαίνουνυδρογόνον, αλογόνον ή αλκύλιον, το δε Χ σημαίνει αλογόνον, και των αλάτων τούτων, χαρακτηριζομένη κατά τούτο ότι μιάν οξίμην της ορθοαμινοβενζοφαινόνης του γενικού τύπου (ΙΙ) είς τον τα R2 ως R4 έχουν την ανωτέρω δοθείσαν σημασίαν, υποβάλλομεν είς ακυλίωσιν μετά τινος α-αλογονακυλο-αλογονιδίου του είς τον οποίον τα R1 και Χ έχουν την ανωτέρω σημασίαν, το δ' ούτω λαμβανόμενον προιόν αφυδατούμεν τηεπιδράσει οξίνων μέσων, και,εάν είναι επιθυμητόν,το λαμβανόμενον προιόν της αντιδρασεως μετατρέπομεν διά τινος οξέος είς έν άλας. A process for the preparation of quinazoline 3-oxides of general formula (I) wherein R1 stands for hydrogen or alkyl, R2 stands for phenyl, for the nitro or halogen substituted phenyl or alkoxyphenyl, R3 and r4 and X means halogen, and of these salts, characterized in that an oxymine of orthoaminobenzophenone of general formula (II) in R2 to R4 has the above significance, subjected to acylation after its α-halogen-derived horse. R1 and X have the above meaning, the product thus obtained is dehydrated by the effect of acidic media, and, if desired, the product of the reaction is converted to an acid in a salt.

GR590122772A 1959-05-13 1959-05-13 METHOD FOR THE PREPARATION OF 3 - KINAZOLINE OXIES. GR22772B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR590122772A GR22772B (en) 1959-05-13 1959-05-13 METHOD FOR THE PREPARATION OF 3 - KINAZOLINE OXIES.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR590122772A GR22772B (en) 1959-05-13 1959-05-13 METHOD FOR THE PREPARATION OF 3 - KINAZOLINE OXIES.

Publications (1)

Publication Number Publication Date
GR22772B true GR22772B (en) 1962-01-29

Family

ID=36864722

Family Applications (1)

Application Number Title Priority Date Filing Date
GR590122772A GR22772B (en) 1959-05-13 1959-05-13 METHOD FOR THE PREPARATION OF 3 - KINAZOLINE OXIES.

Country Status (1)

Country Link
GR (1) GR22772B (en)

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