GB1030022A - Process for the production of isoquinoline derivatives - Google Patents

Process for the production of isoquinoline derivatives

Info

Publication number
GB1030022A
GB1030022A GB1805763A GB1805763A GB1030022A GB 1030022 A GB1030022 A GB 1030022A GB 1805763 A GB1805763 A GB 1805763A GB 1805763 A GB1805763 A GB 1805763A GB 1030022 A GB1030022 A GB 1030022A
Authority
GB
United Kingdom
Prior art keywords
formula
prepared
compound
reacting
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1805763A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orgamol AG
Original Assignee
Orgamol AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orgamol AG filed Critical Orgamol AG
Publication of GB1030022A publication Critical patent/GB1030022A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals

Abstract

Compounds of the general formula <FORM:1030022/C2/1> wherein each X represents a methyl or ethyl group or the X groups together form a methylene group, R2 is aryl or aralkyl which may be substituted by alkyl, alkoxy, or halogen and R1 is hydrogen or C1 to C3 alkyl, are prepared by subjectin a compound of formula <FORM:1030022/C2/2> to a ring closing condensation with phosphorus oxychloride, phosphorus pentoxide, polyphosphoric acid or a mixture thereof, optionally combined with preparing the compounds of the second formula above by reacting a compound of formula <FORM:1030022/C2/3> with a suitable acylating reagent. 1 - (31,41 - Dimethoxyphenyl) - 2 - amino - 1 - butano is prepared by reduction of the 2-nitro compound which is itself prepared by reacting veratraldehyde and 1-nitropropane in the presence of sodium.
GB1805763A 1962-06-16 1963-05-07 Process for the production of isoquinoline derivatives Expired GB1030022A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH731762 1962-06-16

Publications (1)

Publication Number Publication Date
GB1030022A true GB1030022A (en) 1966-05-18

Family

ID=4323225

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1805763A Expired GB1030022A (en) 1962-06-16 1963-05-07 Process for the production of isoquinoline derivatives

Country Status (3)

Country Link
DE (1) DE1184344B (en)
FR (1) FR1362765A (en)
GB (1) GB1030022A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0491441A1 (en) * 1990-12-17 1992-06-24 Shell Internationale Researchmaatschappij B.V. Fungicidal isoquinoline derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8800397D0 (en) * 1988-01-08 1988-02-10 Sandoz Ltd Improvements in/relating to organic compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0491441A1 (en) * 1990-12-17 1992-06-24 Shell Internationale Researchmaatschappij B.V. Fungicidal isoquinoline derivatives
WO1992011242A1 (en) * 1990-12-17 1992-07-09 Shell Internationale Research Maatschappij B.V. Fungicidal isoquinoline derivatives

Also Published As

Publication number Publication date
DE1184344B (en) 1964-12-31
FR1362765A (en) 1964-06-05

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