ES376981A1 - Sydnonimine derivatives - Google Patents

Sydnonimine derivatives

Info

Publication number
ES376981A1
ES376981A1 ES376981A ES376981A ES376981A1 ES 376981 A1 ES376981 A1 ES 376981A1 ES 376981 A ES376981 A ES 376981A ES 376981 A ES376981 A ES 376981A ES 376981 A1 ES376981 A1 ES 376981A1
Authority
ES
Spain
Prior art keywords
heterocyclic ring
substituted
cycloalkyl
halogen
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES376981A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES376981A1 publication Critical patent/ES376981A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of the general formula (R 1 , 2 = alkyl, cycloalkyl, aralkyl optionally substituted by CH 3 or halogen, heterocyclic ring linked via alkylene chain to N, or -NR 1 R 2 = heterocyclic ring optionally containing more than one heteroatom and/or being substituted by CH 3 R 3 = H, -COR 4 (R4 = alkyl, cycloalkyl, Ph, halophenyl, alkoxy, unsubstituted or substituted nitrogen-containing heterocyclic ring) Hal = halogen) and their acid addition salts are prepared by halogenating a compound of the formula or an acid addition salt thereof, optionally followed by deacylation and/or salt formation. The preparation of the starting materials by standard methods is described. The above compounds are hypotensive agents, and the salts may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
ES376981A 1968-03-26 1970-02-27 Sydnonimine derivatives Expired ES376981A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19681770061 DE1770061A1 (en) 1968-03-26 1968-03-26 New substituted 3-amino-4-bromosydnomimines

Publications (1)

Publication Number Publication Date
ES376981A1 true ES376981A1 (en) 1972-05-01

Family

ID=5700383

Family Applications (2)

Application Number Title Priority Date Filing Date
ES364979A Expired ES364979A1 (en) 1968-03-26 1969-03-20 Sydnonimine derivatives
ES376981A Expired ES376981A1 (en) 1968-03-26 1970-02-27 Sydnonimine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES364979A Expired ES364979A1 (en) 1968-03-26 1969-03-20 Sydnonimine derivatives

Country Status (18)

Country Link
AT (1) AT285619B (en)
BE (1) BE730510A (en)
BG (1) BG15220A3 (en)
BR (1) BR6907417D0 (en)
CA (1) CA945990A (en)
CH (1) CH519511A (en)
DE (1) DE1770061A1 (en)
DK (1) DK130296B (en)
ES (2) ES364979A1 (en)
FI (1) FI54480C (en)
FR (1) FR2004770A1 (en)
GB (1) GB1219254A (en)
HU (1) HU162735B (en)
IE (1) IE32708B1 (en)
IL (1) IL31909A (en)
NL (1) NL6904632A (en)
SE (1) SE374746B (en)
YU (1) YU69369A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2930736A1 (en) 1979-07-28 1981-02-12 Cassella Ag PHARMACOLOGICALLY ACTIVE, SUBSTITUTED 3-AMINO-SYDNONIMINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE

Also Published As

Publication number Publication date
CA945990A (en) 1974-04-23
YU69369A (en) 1978-09-18
DE1770061A1 (en) 1971-09-16
ES364979A1 (en) 1971-02-16
BR6907417D0 (en) 1973-04-12
GB1219254A (en) 1971-01-13
IL31909A0 (en) 1969-05-28
DK130296B (en) 1975-02-03
FI54480B (en) 1978-08-31
DK130296C (en) 1975-06-30
CH519511A (en) 1972-02-29
IL31909A (en) 1973-01-30
HU162735B (en) 1973-04-28
IE32708B1 (en) 1973-10-31
BE730510A (en) 1969-09-26
FR2004770A1 (en) 1969-11-28
BG15220A3 (en) 1975-11-21
IE32708L (en) 1969-09-26
AT285619B (en) 1970-11-10
NL6904632A (en) 1969-09-30
SE374746B (en) 1975-03-17
FI54480C (en) 1978-12-11

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