GR1001291B - Πεπτιδια και αντισωματα αναστελλοντα την ζευξιν της integrin μετα συντασσομενης ομαδος. - Google Patents
Πεπτιδια και αντισωματα αναστελλοντα την ζευξιν της integrin μετα συντασσομενης ομαδος.Info
- Publication number
- GR1001291B GR1001291B GR890100632A GR890100632A GR1001291B GR 1001291 B GR1001291 B GR 1001291B GR 890100632 A GR890100632 A GR 890100632A GR 890100632 A GR890100632 A GR 890100632A GR 1001291 B GR1001291 B GR 1001291B
- Authority
- GR
- Greece
- Prior art keywords
- antibodies
- ligand binding
- peptides
- integrin
- polypeptides
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 102000006495 integrins Human genes 0.000 title abstract 2
- 108010044426 integrins Proteins 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 108050007872 Integrin beta subunit Proteins 0.000 abstract 1
- 102000000924 Integrin beta subunit Human genes 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 230000002788 anti-peptide Effects 0.000 abstract 1
- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
- C07K14/70557—Integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Περγράφονται πολυπεπτίδια προερχόμενα εκ της περιοχής δεσμεύσεως (χημικός τύπος) (RGD) μιας β-υπο-ομάδος Integrin ως και η χρήσις αυτών εις την τροποποίησιν της ζεύξεως της 5 Integrin μετά στοιχείου συνδέσεως. Αναφέρονται επίσης αντιπεπτιδικά αντισώματα, υβριδώματα εκκρίνοντα τα τοιαύτα αντισώματα, ως και μέθοδοι παραγωγής και χρήσεως των τοιούτων αντισωμάτων, ως και μόρια DNA εξ ανασυνθέσεως ορίζοντα δομικόν γονίδιον το οποίον κωδικοποιεί τα πολυπεπτίδια, ως εμπίπτοντα εις το αντικείμενον της παρούσης εφευρέσεως. ω
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/252,674 US5149780A (en) | 1988-10-03 | 1988-10-03 | Peptides and antibodies that inhibit integrin-ligand binding |
US07/415,025 US5204445A (en) | 1988-10-03 | 1989-10-02 | Peptides and antibodies that inhibit integrin-ligand binding |
Publications (2)
Publication Number | Publication Date |
---|---|
GR890100632A GR890100632A (en) | 1990-11-29 |
GR1001291B true GR1001291B (el) | 1993-07-30 |
Family
ID=26942544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR890100632A GR1001291B (el) | 1988-10-03 | 1989-10-03 | Πεπτιδια και αντισωματα αναστελλοντα την ζευξιν της integrin μετα συντασσομενης ομαδος. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5204445A (el) |
EP (1) | EP0436660B1 (el) |
AT (1) | ATE136908T1 (el) |
AU (1) | AU4427389A (el) |
CA (1) | CA2000048A1 (el) |
DE (1) | DE68926303T2 (el) |
ES (1) | ES2024728A6 (el) |
GR (1) | GR1001291B (el) |
PT (1) | PT91888A (el) |
WO (1) | WO1990003983A1 (el) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0432249B1 (en) * | 1989-06-02 | 1996-09-25 | The Johns Hopkins University School Of Medicine | Monoclonal antibodies against leukocyte adhesion receptor beta-chain, methods of producing these antibodies and use therefore |
GB8914020D0 (en) † | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5612311A (en) * | 1990-04-06 | 1997-03-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
WO1992003473A1 (en) * | 1990-08-27 | 1992-03-05 | Cetus Corporation | Cd18 peptide medicaments for the treatment of disease |
JPH06507641A (ja) * | 1991-05-03 | 1994-09-01 | ザ ロックフェラー ユニバーシティ | 白血球cr3に対する内皮細胞リガンド認識抗体 |
EP0593572B1 (en) * | 1991-07-01 | 1998-06-17 | The Blood Center Of Southeastern Wisconsin | PEN POLYMORPHISM OF HUMAN PLATELET MEMBRANE GLYCOPROTEIN IIIa AND DIAGNOSTIC AND THERAPEUTIC APPLICATION THEREOF |
US5962643A (en) * | 1991-07-11 | 1999-10-05 | The Regents Of The University Of California | Integrin β subunit and uses thereof |
CA2109398A1 (en) * | 1992-10-30 | 1994-05-01 | Alejandro A. Aruffo | Extracellular matrix receptor ligands that modulate leukocyte function |
EP0762886A4 (en) * | 1994-04-19 | 1999-03-31 | Univ Kansas | ICAM-1 / LFA-1 SHORT CHAIN PEPTIDES AND METHODS FOR USE THEREOF |
US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
US6465253B1 (en) * | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
AU698317B2 (en) | 1995-02-25 | 1998-10-29 | Cancer Research Technology Limited | Transgenic animals as model of psoriasis |
ES2333425T5 (es) * | 1995-06-15 | 2012-08-28 | Crucell Holland B.V. | Sistemas de empaquetado para adenovirus recombinante humano destinados a terapia génica |
US6783980B2 (en) * | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
US5817750A (en) * | 1995-08-28 | 1998-10-06 | La Jolla Cancer Research Foundation | Structural mimics of RGD-binding sites |
PL327679A1 (en) | 1996-01-10 | 1998-12-21 | Nycomed Imaging As | Contast medium |
GB9600427D0 (en) * | 1996-01-10 | 1996-03-13 | Nycomed Imaging As | Contrast media |
US6087332A (en) * | 1997-12-23 | 2000-07-11 | Galler; Lawrence Isaac | Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy |
US20040043489A1 (en) * | 1998-07-08 | 2004-03-04 | Menzo Havenga | Gene delivery vectors provided with a tissue tropism for dendritic cells and methods of use |
US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
US6929946B1 (en) * | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US20050232900A1 (en) * | 1999-05-18 | 2005-10-20 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US6492169B1 (en) * | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
AU6090200A (en) * | 1999-07-15 | 2001-02-05 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Peptides and their utility in modulation of behavior of cells expressing alpha3beta1 integrins |
US7129052B1 (en) * | 2000-07-12 | 2006-10-31 | The United States Of America As Represented By The Department Of Health And Human Services | Peptides and their utility in modulation of behavior of cells expressing α3β1 integrins |
EP1157999A1 (en) * | 2000-05-24 | 2001-11-28 | Introgene B.V. | Methods and means for enhancing skin transplantation using gene delivery vehicles having tropism for primary fibroblasts, as well as other uses thereof |
US20040033605A1 (en) * | 2000-09-20 | 2004-02-19 | Menzo Havenga | Gene delivery vectors provided with a tissue tropism for dendritic cells |
DE60138403D1 (de) * | 2000-09-26 | 2009-05-28 | Crucell Holland Bv | Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten |
MXPA03007878A (es) * | 2001-03-02 | 2004-07-08 | Medimmune Inc | Metodos de prevencion o tratamiento de alteraciones inflamatorias o autoinmunes mediante la administracion de los antagonistas alfav, beta3 de integrina. |
AU2003210661A1 (en) * | 2002-01-24 | 2003-09-02 | Novartis Ag | Fiber shaft modifications for efficient targeting |
CA2478239A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
WO2003075741A2 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | METHODS OF PREVENTING OR TREATING DISORDERS BY ADMINISTERING AN INTEGRIN αvβ3 ANTAGONIST IN COMBINATION WITH AN HMG-CoA REDUCTASE INHIBITOR OR A BISPHOSPHONATE |
AU2003226065B2 (en) * | 2002-04-12 | 2009-02-26 | Ludwig Institute For Cancer Research, Ltd | Recombinant anti-interleukin-9 antibodies |
SI1497438T1 (sl) * | 2002-04-25 | 2010-03-31 | Crucell Holland Bv | Sredstva in postopki za pripravo adenovirusnih vektorjev |
AU2004207002A1 (en) * | 2003-01-30 | 2004-08-12 | Medimmune, Inc. | Uses of integrin alphavbeta3 antagonists |
KR20120035234A (ko) * | 2003-04-11 | 2012-04-13 | 메디뮨 엘엘씨 | 재조합 il?9 항체 및 그의 용도 |
US7351739B2 (en) * | 2004-04-30 | 2008-04-01 | Wellgen, Inc. | Bioactive compounds and methods of uses thereof |
EP2422811A2 (en) | 2004-10-27 | 2012-02-29 | MedImmune, LLC | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
EP2043603A4 (en) | 2006-07-11 | 2010-10-27 | Arubor Corp | PREVENTION AND THERAPY OF RHINOSINUSITIS WITH PROINFLAMMATORY CYTOKINHERMERS |
HUE048024T2 (hu) | 2006-08-10 | 2020-05-28 | Roy C Levitt | Anakinra bronchiolitis obliterans szindróma kezelésében való alkalmazásra |
EP4219560A3 (en) * | 2010-02-18 | 2023-08-23 | The Regents of The University of California | Integrin alpha v beta 8 neutralizing antibody |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988006592A1 (en) * | 1987-02-26 | 1988-09-07 | Dana-Farber Cancer Institute, Inc. | Cloning of lfa-1 |
US5114842A (en) * | 1987-07-08 | 1992-05-19 | The Scripps Research Institute | Peptides and antibodies that inhibit platelet adhesion |
-
1989
- 1989-10-02 US US07/415,025 patent/US5204445A/en not_active Expired - Fee Related
- 1989-10-02 CA CA002000048A patent/CA2000048A1/en not_active Abandoned
- 1989-10-03 ES ES8903327A patent/ES2024728A6/es not_active Expired - Lifetime
- 1989-10-03 AT AT89911963T patent/ATE136908T1/de not_active IP Right Cessation
- 1989-10-03 EP EP89911963A patent/EP0436660B1/en not_active Expired - Lifetime
- 1989-10-03 WO PCT/US1989/004371 patent/WO1990003983A1/en active IP Right Grant
- 1989-10-03 AU AU44273/89A patent/AU4427389A/en not_active Abandoned
- 1989-10-03 DE DE68926303T patent/DE68926303T2/de not_active Expired - Fee Related
- 1989-10-03 GR GR890100632A patent/GR1001291B/el unknown
- 1989-10-03 PT PT198991888A patent/PT91888A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2000048A1 (en) | 1990-04-03 |
ATE136908T1 (de) | 1996-05-15 |
US5204445A (en) | 1993-04-20 |
EP0436660B1 (en) | 1996-04-17 |
DE68926303T2 (de) | 1996-11-21 |
DE68926303D1 (de) | 1996-05-23 |
EP0436660A4 (en) | 1992-02-12 |
WO1990003983A1 (en) | 1990-04-19 |
EP0436660A1 (en) | 1991-07-17 |
ES2024728A6 (es) | 1992-03-01 |
AU4427389A (en) | 1990-05-01 |
PT91888A (pt) | 1990-04-30 |
GR890100632A (en) | 1990-11-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GR890100632A (en) | Peptides and antibodies that inhibit integrin - ligand binding | |
IL148021A0 (en) | Novel b7-4 molecules and uses therefor | |
NO964650D0 (no) | LAG-3 protein-opplöselige polypeptidfraksjoner, fremgangsmåte for fremstilling, teraupeutisk preparat og anti-idiotype antistoff | |
EP1190043A4 (en) | GLYCOPROTEIN VI AND ITS USES | |
HK129394A (en) | Recombinant immunoglobulin preparations, methods for their preparation, dna sequences, expression vectors and recombinant host cells therefor | |
WO1999002552A3 (en) | Chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof | |
EP0460076A4 (en) | Genetically engineered immunoglobulins | |
GR3019849T3 (en) | Acute pancreatitis associated protein and means for the diagnosis of acute pancreatitis | |
AU7599500A (en) | Novel gl50 molecules and uses therefor | |
DE59708952D1 (de) | Fusionspolypeptid zur beeinflussung von wechselwirkungen zwischen proteinen | |
IL69469A (en) | Polypeptide having human h1-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors | |
EP1009752A4 (en) | NOVEL TANGO-77 PROTEIN FAMILY MOLECULES AND USES THEREOF | |
DE69930625D1 (de) | Rekombinante aav-vektoren für die gentherapie von hämophilie a | |
DE60044193D1 (en) | Tumor antigen | |
ATE233811T1 (de) | Blutplaettchen-gpiiia p1a1 und -p1a2-epitope, ihre herstellung und verwendung | |
UA72875C2 (uk) | БІЛКИ, ЯКІ ЗВ'ЯЗУЮТЬСЯ З <font face="Symbol">b</font>-АМІЛОЇДНИМ ПЕПТИДОМ ТА ПОЛІНУКЛЕОТИДИ, ЩО ЇХ КОДУЮТЬ | |
WO2000012544A3 (en) | Novel irap-bp polypeptide and nucleic acid molecules and uses therefor | |
SG54291A1 (en) | Monoclonal antibodies to antigens expressed by hematopoietic facilitatory cells | |
AU3931599A (en) | Basb019 proteins and genes from (moraxella catarrhalis), antigens, antibodies, and uses | |
HK1037209A1 (en) | Proteins and genes from moraxella catarrhalis, antigens, antibodies, and uses | |
WO2000018890A3 (en) | Protein phosphatase molecules and uses therefor | |
WO2000041539A3 (en) | Human beta-1,3-galactosyltransferase homolog, znssp6 | |
WO1998057992A3 (de) | Antikörper gegen flip-protein | |
IT1276724B1 (it) | Vettore plasmidico di espressione per cellule di mammifero |