ES2024728A6 - Procedimiento de preparacion de anticuerpos que inhiben la union de integrina-ligando. - Google Patents
Procedimiento de preparacion de anticuerpos que inhiben la union de integrina-ligando.Info
- Publication number
- ES2024728A6 ES2024728A6 ES8903327A ES8903327A ES2024728A6 ES 2024728 A6 ES2024728 A6 ES 2024728A6 ES 8903327 A ES8903327 A ES 8903327A ES 8903327 A ES8903327 A ES 8903327A ES 2024728 A6 ES2024728 A6 ES 2024728A6
- Authority
- ES
- Spain
- Prior art keywords
- antibodies
- ligand binding
- peptides
- integrin
- polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
- C07K14/70557—Integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE NUCLEOTIDOS, A PARTIR DE UN ANIMAL INMUNIZADO CON UN INMUNOGENO QUE COMPRENDE UNA SUBUNIDAD BETA DE INTEGRINA O UN POLIPEPTIDO DE LA INVENCION, DE UN ANTICUERPO MONOCLONAL QUE INMUNORREACCIONA CON UN POLIPEPTIDO DE LA INVENCION Y LA SUBUNIDAD BETA DE INTEGRINA A LA QUE CORRESPONDE LA SECUENCIA DE RESTOS AMINOACIDOS DE DICHO POLIPEPTIDO, MEDIANTE LA PREPARACION DE UNA SUSPENSION DE CELULAS PRODUCTORAS DE ANTICUERPO RECOGIDAS DEL MAMIFERO INMUNIZADO, LA SEPARACION DE LOS ESPLENOCITOS INDIVIDUALES, EL TRATAMIENTO DE LAS CELULAS PRODUCTORAS DE ANTICUERPOS CON UN AGENTE TRANSFORMADOR, CAPAZ DE PRODUCIR UNA LINEA DE CELULAS TRANSFORMADAS, LA CLONACION DE LAS MISMAS EN UN MEDIO QUE NO CONTENGA CELULAS NO TRANSFORMADAS Y LA DETERMINACION DE LA PRESENCIA DE MOLECULAS DE ANTICUERPO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/252,674 US5149780A (en) | 1988-10-03 | 1988-10-03 | Peptides and antibodies that inhibit integrin-ligand binding |
US07/415,025 US5204445A (en) | 1988-10-03 | 1989-10-02 | Peptides and antibodies that inhibit integrin-ligand binding |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2024728A6 true ES2024728A6 (es) | 1992-03-01 |
Family
ID=26942544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8903327A Expired - Lifetime ES2024728A6 (es) | 1988-10-03 | 1989-10-03 | Procedimiento de preparacion de anticuerpos que inhiben la union de integrina-ligando. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5204445A (es) |
EP (1) | EP0436660B1 (es) |
AT (1) | ATE136908T1 (es) |
AU (1) | AU4427389A (es) |
CA (1) | CA2000048A1 (es) |
DE (1) | DE68926303T2 (es) |
ES (1) | ES2024728A6 (es) |
GR (1) | GR1001291B (es) |
PT (1) | PT91888A (es) |
WO (1) | WO1990003983A1 (es) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990015076A2 (en) * | 1989-06-02 | 1990-12-13 | The Johns Hopkins University School Of Medicine | MONOCLONAL ANTIBODIES AGAINST LEUKOCYTE ADHESION RECEPTOR β-CHAIN, METHODS OF PRODUCING THESE ANTIBODIES AND USE THEREFORE |
GB8914020D0 (en) † | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5612311A (en) | 1990-04-06 | 1997-03-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
EP0546077A1 (en) * | 1990-08-27 | 1993-06-16 | Chiron Corporation | Cd18 peptide medicaments for the treatment of disease |
EP0584273B1 (en) * | 1991-05-03 | 1998-12-30 | The Rockefeller University | Antibody recognizing endothelial cell ligand for leukocyte cr3 |
WO1993001315A1 (en) * | 1991-07-01 | 1993-01-21 | The Blood Center Of Southeastern Wisconsin | PEN POLYMORPHISM OF HUMAN PLATELET MEMBRANE GLYCOPROTEIN IIIa AND DIAGNOSTIC AND THERAPEUTIC APPLICATION THEREOF |
US5962643A (en) | 1991-07-11 | 1999-10-05 | The Regents Of The University Of California | Integrin β subunit and uses thereof |
FI934751A (fi) * | 1992-10-30 | 1994-05-01 | Bristol Myers Squibb Co | Extracellulaera matrisreceptorligander som modulerar leukocytfunktioner |
WO1995028170A1 (en) * | 1994-04-19 | 1995-10-26 | The University Of Kansas | Icam-1/lfa-1 short-chain peptides and method of using same |
US6465253B1 (en) * | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
CA2213669A1 (en) | 1995-02-25 | 1996-09-06 | Joseph Michael Carroll | Transgenic animals as model of psoriasis |
US6783980B2 (en) * | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
DK1445322T4 (da) | 1995-06-15 | 2012-09-03 | Crucell Holland Bv | Pakningssystemer for humant rekombinant adenovirus til anvendelse ved genterapi |
US5817750A (en) * | 1995-08-28 | 1998-10-06 | La Jolla Cancer Research Foundation | Structural mimics of RGD-binding sites |
ES2239349T3 (es) | 1996-01-10 | 2005-09-16 | Amersham Health As | Medio de contraste. |
GB9600427D0 (en) * | 1996-01-10 | 1996-03-13 | Nycomed Imaging As | Contrast media |
US6087332A (en) * | 1997-12-23 | 2000-07-11 | Galler; Lawrence Isaac | Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy |
US20040043489A1 (en) * | 1998-07-08 | 2004-03-04 | Menzo Havenga | Gene delivery vectors provided with a tissue tropism for dendritic cells and methods of use |
US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
US6492169B1 (en) * | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
US6913922B1 (en) * | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US20050232900A1 (en) * | 1999-05-18 | 2005-10-20 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
AU6090200A (en) * | 1999-07-15 | 2001-02-05 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Peptides and their utility in modulation of behavior of cells expressing alpha3beta1 integrins |
US7129052B1 (en) | 2000-07-12 | 2006-10-31 | The United States Of America As Represented By The Department Of Health And Human Services | Peptides and their utility in modulation of behavior of cells expressing α3β1 integrins |
EP1157999A1 (en) * | 2000-05-24 | 2001-11-28 | Introgene B.V. | Methods and means for enhancing skin transplantation using gene delivery vehicles having tropism for primary fibroblasts, as well as other uses thereof |
CA2421864A1 (en) * | 2000-09-20 | 2002-03-28 | Crucell Holland B.V. | Transduction of dendritic cells using adenoviral vectors |
DE60138403D1 (de) * | 2000-09-26 | 2009-05-28 | Crucell Holland Bv | Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten |
WO2002070007A1 (en) * | 2001-03-02 | 2002-09-12 | Medimmune, Inc. | Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav beta3 antagonists |
JP4488290B2 (ja) * | 2002-01-24 | 2010-06-23 | ザ・スクリップス・リサーチ・インスティテュート | 効率的ターゲティングのためのファイバーシャフト変異 |
WO2003075957A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
JP2005525368A (ja) * | 2002-03-04 | 2005-08-25 | メディミューン,インコーポレーテッド | インテグリンαvβ3アンタゴニストをHMG−CoA還元酵素阻害剤またはビスフォスフォネートと併用投与する障害の予防または治療方法 |
AU2003226065B2 (en) | 2002-04-12 | 2009-02-26 | Ludwig Institute For Cancer Research, Ltd | Recombinant anti-interleukin-9 antibodies |
KR101021387B1 (ko) * | 2002-04-25 | 2011-03-14 | 크루셀 홀란드 비.브이. | 아데노바이러스 벡터를 생산하기 위한 수단 및 방법 |
AU2004207002A1 (en) * | 2003-01-30 | 2004-08-12 | Medimmune, Inc. | Uses of integrin alphavbeta3 antagonists |
EP1613273B1 (en) * | 2003-04-11 | 2012-06-13 | MedImmune, LLC | Recombinant il-9 antibodies and uses thereof |
US7351739B2 (en) * | 2004-04-30 | 2008-04-01 | Wellgen, Inc. | Bioactive compounds and methods of uses thereof |
WO2006047639A2 (en) | 2004-10-27 | 2006-05-04 | Medimmune, Inc. | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
CA2657581A1 (en) | 2006-07-11 | 2008-01-17 | Roy C. Levitt | Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors |
EP2068889B1 (en) | 2006-08-10 | 2019-10-23 | Roy C. Levitt | Anakinra for use in the treatment of bronchiolitis obliterans syndrome |
US9290572B2 (en) * | 2010-02-18 | 2016-03-22 | The Regents Of The University Of California | Integrin α-Vβ8 neutralizing antibody |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01502879A (ja) * | 1987-02-26 | 1989-10-05 | ダナ ファーバー キャンサー インスティテュート | Lfa―1のクローニング |
US5114842A (en) * | 1987-07-08 | 1992-05-19 | The Scripps Research Institute | Peptides and antibodies that inhibit platelet adhesion |
-
1989
- 1989-10-02 US US07/415,025 patent/US5204445A/en not_active Expired - Fee Related
- 1989-10-02 CA CA002000048A patent/CA2000048A1/en not_active Abandoned
- 1989-10-03 PT PT198991888A patent/PT91888A/pt not_active Application Discontinuation
- 1989-10-03 DE DE68926303T patent/DE68926303T2/de not_active Expired - Fee Related
- 1989-10-03 AU AU44273/89A patent/AU4427389A/en not_active Abandoned
- 1989-10-03 AT AT89911963T patent/ATE136908T1/de not_active IP Right Cessation
- 1989-10-03 WO PCT/US1989/004371 patent/WO1990003983A1/en active IP Right Grant
- 1989-10-03 EP EP89911963A patent/EP0436660B1/en not_active Expired - Lifetime
- 1989-10-03 ES ES8903327A patent/ES2024728A6/es not_active Expired - Lifetime
- 1989-10-03 GR GR890100632A patent/GR1001291B/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0436660A1 (en) | 1991-07-17 |
GR1001291B (el) | 1993-07-30 |
WO1990003983A1 (en) | 1990-04-19 |
EP0436660B1 (en) | 1996-04-17 |
ATE136908T1 (de) | 1996-05-15 |
DE68926303D1 (de) | 1996-05-23 |
AU4427389A (en) | 1990-05-01 |
DE68926303T2 (de) | 1996-11-21 |
GR890100632A (en) | 1990-11-29 |
EP0436660A4 (en) | 1992-02-12 |
PT91888A (pt) | 1990-04-30 |
CA2000048A1 (en) | 1990-04-03 |
US5204445A (en) | 1993-04-20 |
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