WO2000034485A3 - Beta-1,3-galactosyltransferase homologs - Google Patents

Beta-1,3-galactosyltransferase homologs Download PDF

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Publication number
WO2000034485A3
WO2000034485A3 PCT/US1999/029477 US9929477W WO0034485A3 WO 2000034485 A3 WO2000034485 A3 WO 2000034485A3 US 9929477 W US9929477 W US 9929477W WO 0034485 A3 WO0034485 A3 WO 0034485A3
Authority
WO
WIPO (PCT)
Prior art keywords
galactosyltransferase
homologs
beta
znssp2
polypeptides
Prior art date
Application number
PCT/US1999/029477
Other languages
French (fr)
Other versions
WO2000034485A2 (en
Inventor
Darrell C Conklin
Gayle Yamamoto
Stephen R Jaspers
Zeren Gao
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to JP2000586918A priority Critical patent/JP2002531131A/en
Priority to CA002354026A priority patent/CA2354026A1/en
Priority to EP99973307A priority patent/EP1137783A2/en
Priority to AU45192/00A priority patent/AU4519200A/en
Publication of WO2000034485A2 publication Critical patent/WO2000034485A2/en
Publication of WO2000034485A3 publication Critical patent/WO2000034485A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to polynucleotide and polypeptide molecules for znssp2, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp2 polypeptides.
PCT/US1999/029477 1998-12-10 1999-12-10 Beta-1,3-galactosyltransferase homologs WO2000034485A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000586918A JP2002531131A (en) 1998-12-10 1999-12-10 β-1,3-galactosyltransferase homolog
CA002354026A CA2354026A1 (en) 1998-12-10 1999-12-10 Beta-1,3-galactosyltransferase homologs
EP99973307A EP1137783A2 (en) 1998-12-10 1999-12-10 Beta-1,3-galactosyltransferase homologs
AU45192/00A AU4519200A (en) 1998-12-10 1999-12-10 Beta-1,3-galactosyltransferase homologs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20897098A 1998-12-10 1998-12-10
US09/208,970 1998-12-10

Publications (2)

Publication Number Publication Date
WO2000034485A2 WO2000034485A2 (en) 2000-06-15
WO2000034485A3 true WO2000034485A3 (en) 2000-10-19

Family

ID=22776806

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/029477 WO2000034485A2 (en) 1998-12-10 1999-12-10 Beta-1,3-galactosyltransferase homologs

Country Status (5)

Country Link
EP (1) EP1137783A2 (en)
JP (1) JP2002531131A (en)
AU (1) AU4519200A (en)
CA (1) CA2354026A1 (en)
WO (1) WO2000034485A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115839A1 (en) * 2000-08-31 2002-08-22 Millennium Pharmaceuticals, Inc. 8797, a novel human galactosyltransferase and uses thereof
AU2003296161B2 (en) * 2002-12-27 2009-12-17 National Institute Of Advanced Industrial Science And Technology Glycosyltransferase, nucleic acid encoding the glycosyltransferase and method of testing canceration using the nucleic acid
DE602004026157D1 (en) * 2003-01-10 2010-05-06 Protein Crystal Co Ltd PROTEIN COMPLEX, METHOD FOR THE PRODUCTION AND USE THEREOF

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0378188A1 (en) * 1989-01-11 1990-07-18 Konica Corporation Cancer-related human galactosyltransferase, its use and diagnostics
US5955282A (en) * 1998-04-03 1999-09-21 Incyte Pharmaceuticals, Inc. Human galactosyltransferases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0378188A1 (en) * 1989-01-11 1990-07-18 Konica Corporation Cancer-related human galactosyltransferase, its use and diagnostics
US5955282A (en) * 1998-04-03 1999-09-21 Incyte Pharmaceuticals, Inc. Human galactosyltransferases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AMADO M ET AL: "A Family of human beta3-Galactosyltransferases (subtitle: characterization of four members of a udp-galactose:BETA-n-acetyl-glu cosamine/BETA-nacetyl-galactosamine BETA-1,3- galactosyltransferase family", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 21, 22 May 1998 (1998-05-22), pages 12770 - 12778, XP002109786, ISSN: 0021-9258 *
ASANO ET AL.: "Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal defferentiation of epithelial cells", THE EMBO JOURNAL, vol. 16, no. 8, 15 April 1997 (1997-04-15), pages 1850 - 1857, XP002138972 *
DOE JOINT GENOME INSTITUTE: "Sequencing of human chromosome 19", EMBL SEQUENCE DATABASE, 8 October 1999 (1999-10-08), HEIDELBERG DE, XP002138973 *
DOE JOINT GENOME INSTITUTE: "Sequencing of Human Cromosome 19", EMBL SEQUENCE DATABASE, 8 October 1999 (1999-10-08), HEIDELBERG DE, XP002138974 *

Also Published As

Publication number Publication date
AU4519200A (en) 2000-06-26
CA2354026A1 (en) 2000-06-15
EP1137783A2 (en) 2001-10-04
WO2000034485A2 (en) 2000-06-15
JP2002531131A (en) 2002-09-24

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