WO2001032871A3 - Follistatin-related protein zfsta4 - Google Patents

Follistatin-related protein zfsta4 Download PDF

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Publication number
WO2001032871A3
WO2001032871A3 PCT/US2000/030013 US0030013W WO0132871A3 WO 2001032871 A3 WO2001032871 A3 WO 2001032871A3 US 0030013 W US0030013 W US 0030013W WO 0132871 A3 WO0132871 A3 WO 0132871A3
Authority
WO
WIPO (PCT)
Prior art keywords
zfsta4
follistatin
related protein
polypeptides
present
Prior art date
Application number
PCT/US2000/030013
Other languages
French (fr)
Other versions
WO2001032871A2 (en
Inventor
Darrell C Conklin
Paul O Sheppard
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to CA002389956A priority Critical patent/CA2389956A1/en
Priority to JP2001535553A priority patent/JP2003527099A/en
Priority to EP00975521A priority patent/EP1226249A2/en
Priority to AU13564/01A priority patent/AU1356401A/en
Publication of WO2001032871A2 publication Critical patent/WO2001032871A2/en
Publication of WO2001032871A3 publication Critical patent/WO2001032871A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to polynucleotide and polypeptide molecules for zfsta4, a novel member of the follistatin family. The polypeptides, and polynucleotides encoding them are useful for binding to members of the TGF-β family and mediating central nervous system, reproductive, hematopoietic and bone-related activities. The present invention also includes antibodies to the zfsta4 polypeptides.
PCT/US2000/030013 1999-11-03 2000-10-31 Follistatin-related protein zfsta4 WO2001032871A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002389956A CA2389956A1 (en) 1999-11-03 2000-10-31 Follistatin-related protein zfsta4
JP2001535553A JP2003527099A (en) 1999-11-03 2000-10-31 Follistatin-related protein ZFSTA4
EP00975521A EP1226249A2 (en) 1999-11-03 2000-10-31 Follistatin-related protein zfsta4
AU13564/01A AU1356401A (en) 1999-11-03 2000-10-31 Follistatin-related protein zfsta4

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43235999A 1999-11-03 1999-11-03
US09/432,359 1999-11-03

Publications (2)

Publication Number Publication Date
WO2001032871A2 WO2001032871A2 (en) 2001-05-10
WO2001032871A3 true WO2001032871A3 (en) 2002-02-21

Family

ID=23715814

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/030013 WO2001032871A2 (en) 1999-11-03 2000-10-31 Follistatin-related protein zfsta4

Country Status (5)

Country Link
EP (1) EP1226249A2 (en)
JP (1) JP2003527099A (en)
AU (1) AU1356401A (en)
CA (1) CA2389956A1 (en)
WO (1) WO2001032871A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050075283A1 (en) * 2001-07-13 2005-04-07 Applera Corporation Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
KR20040096592A (en) * 2002-02-21 2004-11-16 와이어쓰 Follistatin domain containing proteins
JP4688483B2 (en) * 2004-04-15 2011-05-25 株式会社テクノネットワーク四国 Follistatin variant polypeptide
US20050287559A1 (en) * 2004-05-07 2005-12-29 Applera Corporation Genetic polymorphisms associated with vascular, methods of detection and uses thereof
WO2008002663A2 (en) 2006-06-28 2008-01-03 The Board Of Trustees Of The Leland Stanford Junior University Immunogenic protein constructs
US20100063258A1 (en) * 2006-06-28 2010-03-11 The Board Of Trustees Of The Leland Stanford Junior University Fusion protein constructs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998054358A1 (en) * 1997-05-26 1998-12-03 Monash University A method of diagnosing abnormal cell growth
WO1999025371A1 (en) * 1997-11-17 1999-05-27 Millennium Pharmaceuticals, Inc. Novel molecules of the follistatin-related protein family and uses therefor
WO2000061754A2 (en) * 1999-04-09 2000-10-19 Curagen Corporation Human proteins and polynucleotides encoding them

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998054358A1 (en) * 1997-05-26 1998-12-03 Monash University A method of diagnosing abnormal cell growth
WO1999025371A1 (en) * 1997-11-17 1999-05-27 Millennium Pharmaceuticals, Inc. Novel molecules of the follistatin-related protein family and uses therefor
WO2000061754A2 (en) * 1999-04-09 2000-10-19 Curagen Corporation Human proteins and polynucleotides encoding them

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_HTG EMBL; 17 September 1999 (1999-09-17), DOE JOINT GENOME INSTITUTE: "Homo sapiens chromosome 5 clone CTB-49A3, WORKING DRAFT SEQUENCE, 53 unordered pieces.", XP002172088 *
DATABASE EM_HTG EMBL; 4 August 1999 (1999-08-04), DOE JOINT GENOME INSTITUTE: "Homo sapiens chromosome 5 clone CTC-439D5, WORKING DRAFT SEQUENCE, 19 unordered pieces.", XP002172087 *
DATABASE EM_HUM EMBL; 30 June 1998 (1998-06-30), KIMMERLY W ET AL.: "Homo sapiens chromosome 5, P1 clone 1265G12 (LBNL H58), complete sequence.", XP002172086 *
DATABASE EM_HUM EMBL; 4 August 1999 (1999-08-04), OHARA O ET AL.: "Homo sapiens mRNA for KIAA1061 protein, partial cds.", XP002172085 *
KIKUNO R ET AL.: "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which encod for large proteins in vitro", DNA RESEARCH, vol. 6, no. 3, 30 June 1999 (1999-06-30), pages 197 - 205, XP000852618 *
TANAKA M ET AL.: "Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases", INTERNATIONAL IMMUNOLOGY, vol. 10, no. 9, 1998, pages 1305 - 1314, XP000945149, ISSN: 0953-8178 *
ZWIJSEN A ET AL.: "Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP);cloning and sequencing of the human homologue", EUROPEAN JOURNAL OF BIOCHEMISTRYEUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 225, no. 3, November 1994 (1994-11-01), pages 937 - 946, XP002103181, ISSN: 0014-2956 *

Also Published As

Publication number Publication date
WO2001032871A2 (en) 2001-05-10
JP2003527099A (en) 2003-09-16
EP1226249A2 (en) 2002-07-31
AU1356401A (en) 2001-05-14
CA2389956A1 (en) 2001-02-10

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