WO2000012544A3 - Novel irap-bp polypeptide and nucleic acid molecules and uses therefor - Google Patents

Novel irap-bp polypeptide and nucleic acid molecules and uses therefor Download PDF

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Publication number
WO2000012544A3
WO2000012544A3 PCT/US1999/019473 US9919473W WO0012544A3 WO 2000012544 A3 WO2000012544 A3 WO 2000012544A3 US 9919473 W US9919473 W US 9919473W WO 0012544 A3 WO0012544 A3 WO 0012544A3
Authority
WO
WIPO (PCT)
Prior art keywords
irap
nucleic acid
acid molecules
novel
polypeptide
Prior art date
Application number
PCT/US1999/019473
Other languages
French (fr)
Other versions
WO2000012544A2 (en
Inventor
Paul F Pilch
Hideaki Tojo
Baozhen Lin
Original Assignee
Univ Boston
Paul F Pilch
Hideaki Tojo
Baozhen Lin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Boston, Paul F Pilch, Hideaki Tojo, Baozhen Lin filed Critical Univ Boston
Priority to AU59011/99A priority Critical patent/AU5901199A/en
Priority to EP99946647A priority patent/EP1107987A2/en
Priority to JP2000567562A priority patent/JP2002523078A/en
Priority to CA002340796A priority patent/CA2340796A1/en
Publication of WO2000012544A2 publication Critical patent/WO2000012544A2/en
Publication of WO2000012544A3 publication Critical patent/WO2000012544A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Novel IRAP-BP polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length IRAP-BP polypeptides, the invention further provides isolated IRAP-BP fusion proteins, antigenic peptides and anti-IRAP-BP antibodies. The invention also provides IRAP-BP nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an IRAP-BP gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
PCT/US1999/019473 1998-08-26 1999-08-26 Novel irap-bp polypeptide and nucleic acid molecules and uses therefor WO2000012544A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU59011/99A AU5901199A (en) 1998-08-26 1999-08-26 Novel irap-bp polypeptide and nucleic acid molecules and uses therefor
EP99946647A EP1107987A2 (en) 1998-08-26 1999-08-26 Novel irap-bp polypeptide and nucleic acid molecules and uses therefor
JP2000567562A JP2002523078A (en) 1998-08-26 1999-08-26 Novel IRAP-BP polypeptides and nucleic acid molecules and uses thereof
CA002340796A CA2340796A1 (en) 1998-08-26 1999-08-26 Novel irap-bp polypeptide and nucleic acid molecules and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9801598P 1998-08-26 1998-08-26
US60/098,015 1998-08-26

Publications (2)

Publication Number Publication Date
WO2000012544A2 WO2000012544A2 (en) 2000-03-09
WO2000012544A3 true WO2000012544A3 (en) 2000-06-22

Family

ID=22266276

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/019473 WO2000012544A2 (en) 1998-08-26 1999-08-26 Novel irap-bp polypeptide and nucleic acid molecules and uses therefor

Country Status (5)

Country Link
EP (1) EP1107987A2 (en)
JP (1) JP2002523078A (en)
AU (1) AU5901199A (en)
CA (1) CA2340796A1 (en)
WO (1) WO2000012544A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7064106B2 (en) 1999-12-20 2006-06-20 Takeda Chemical Industries, Ltd. Gene and use thereof
US20040086510A1 (en) * 2000-08-21 2004-05-06 Hideaki Tojo Irap-binding protein
WO2002018420A2 (en) * 2000-08-28 2002-03-07 Lion Bioscience Ag Cofactors of the pregnane x receptor and methods of use
DE10054639B4 (en) * 2000-11-03 2004-05-06 Jenapharm Gmbh & Co. Kg Use of RanBPM as a co-modulator of steroid hormone receptors
AU2002259211A1 (en) * 2001-05-11 2002-11-25 Adipogenix, Inc. Identifying insulin response modulators and therapeutic uses thereof
AU2002259209A1 (en) * 2001-05-11 2002-11-25 Adipogenix, Inc. Methods and reagents for identifying insulin response modulators and therapeutic uses therefor
US20050020519A1 (en) * 2001-08-02 2005-01-27 Albiston Anthony L. Modulation of insulin-regulated aminopeptidase (irap)/angiotensin iv (at4) receptor activity
EP1917021A2 (en) * 2005-08-23 2008-05-07 Wyeth a Corporation of the State of Delaware Methods for the treatment of anxiety and for identification of anxiolytic agents
FR2949156B1 (en) 2009-08-13 2016-04-15 Cis-Bio Int METHOD FOR DETERMINING THE BINDING OF A COMPOUND GIVEN TO A MEMBRANE RECEPTOR
WO2023099589A1 (en) 2021-12-01 2023-06-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Irap inhibitors for use in the treatment of inflammatory diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009317A1 (en) * 1994-09-20 1996-03-28 Bayer Corporation Cloning of an insulin-dependent membrane aminopeptidase from glut-4 vesicles
WO1998012327A2 (en) * 1996-09-20 1998-03-26 Board Of Regents, The University Of Texas System Compositions and methods comprising bard1 and other brca1 binding proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009317A1 (en) * 1994-09-20 1996-03-28 Bayer Corporation Cloning of an insulin-dependent membrane aminopeptidase from glut-4 vesicles
WO1998012327A2 (en) * 1996-09-20 1998-03-26 Board Of Regents, The University Of Texas System Compositions and methods comprising bard1 and other brca1 binding proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KANDROR, K.V. & PILCH, P.F.: "Multiple endosomal recycling pathways in rat adipose cells", BIOCHEM. J., vol. 331, 1998, pages 829 - 835, XP000872652 *

Also Published As

Publication number Publication date
AU5901199A (en) 2000-03-21
CA2340796A1 (en) 2000-03-09
WO2000012544A2 (en) 2000-03-09
JP2002523078A (en) 2002-07-30
EP1107987A2 (en) 2001-06-20

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