GB999393A - New ethers of the yohimbane series and process for their manufacture - Google Patents
New ethers of the yohimbane series and process for their manufactureInfo
- Publication number
- GB999393A GB999393A GB28119/61A GB2811961A GB999393A GB 999393 A GB999393 A GB 999393A GB 28119/61 A GB28119/61 A GB 28119/61A GB 2811961 A GB2811961 A GB 2811961A GB 999393 A GB999393 A GB 999393A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- group
- general formula
- salts
- represent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002170 ethers Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- JUPDIHMJFPDGMY-DEYYWGMASA-N yohimban Chemical class C1=CC=C2C(CCN3C[C@@H]4CCCC[C@H]4C[C@H]33)=C3NC2=C1 JUPDIHMJFPDGMY-DEYYWGMASA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 5
- 150000001204 N-oxides Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- -1 sulphonic acid halides Chemical class 0.000 abstract 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical class NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- 238000006136 alcoholysis reaction Methods 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229960005015 local anesthetics Drugs 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001477 organic nitrogen group Chemical group 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4691160A | 1960-08-02 | 1960-08-02 | |
| US7349060A | 1960-12-05 | 1960-12-05 | |
| US11032061A | 1961-05-16 | 1961-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB999393A true GB999393A (en) | 1965-07-28 |
Family
ID=27367016
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28118/61A Expired GB999392A (en) | 1960-08-02 | 1961-08-02 | New ethers of the yohimbane series and process for their manufacture |
| GB46383/64A Expired GB999397A (en) | 1960-08-02 | 1961-08-02 | New esters of the vohimbane series and process for their manufacture |
| GB49912/64A Expired GB999398A (en) | 1960-08-02 | 1961-08-02 | New esters of the yohimbane series and process for their manufacture |
| GB28117/61A Expired GB999391A (en) | 1960-08-02 | 1961-08-02 | Ethers of methyl 18-epi-reserpate and salts thereof and process for their manufacture |
| GB52687/64A Expired GB999399A (en) | 1960-08-02 | 1961-08-02 | New esters of the yohimbane series and process for their manufacture |
| GB28119/61A Expired GB999393A (en) | 1960-08-02 | 1961-08-02 | New ethers of the yohimbane series and process for their manufacture |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28118/61A Expired GB999392A (en) | 1960-08-02 | 1961-08-02 | New ethers of the yohimbane series and process for their manufacture |
| GB46383/64A Expired GB999397A (en) | 1960-08-02 | 1961-08-02 | New esters of the vohimbane series and process for their manufacture |
| GB49912/64A Expired GB999398A (en) | 1960-08-02 | 1961-08-02 | New esters of the yohimbane series and process for their manufacture |
| GB28117/61A Expired GB999391A (en) | 1960-08-02 | 1961-08-02 | Ethers of methyl 18-epi-reserpate and salts thereof and process for their manufacture |
| GB52687/64A Expired GB999399A (en) | 1960-08-02 | 1961-08-02 | New esters of the yohimbane series and process for their manufacture |
Country Status (6)
| Country | Link |
|---|---|
| AT (7) | AT252463B (enrdf_load_stackoverflow) |
| CH (8) | CH410969A (enrdf_load_stackoverflow) |
| ES (3) | ES269515A1 (enrdf_load_stackoverflow) |
| GB (6) | GB999392A (enrdf_load_stackoverflow) |
| NL (1) | NL139529B (enrdf_load_stackoverflow) |
| SE (7) | SE301650B (enrdf_load_stackoverflow) |
-
1961
- 1961-07-12 CH CH819361A patent/CH410969A/de unknown
- 1961-07-12 CH CH308765A patent/CH407146A/de unknown
- 1961-07-12 CH CH819261A patent/CH416658A/de unknown
- 1961-07-12 CH CH308465A patent/CH407143A/de unknown
- 1961-07-12 CH CH308565A patent/CH407144A/de unknown
- 1961-07-12 CH CH308665A patent/CH407145A/de unknown
- 1961-07-12 CH CH819161A patent/CH398628A/de unknown
- 1961-07-12 CH CH819061A patent/CH398627A/de unknown
- 1961-08-01 AT AT887662A patent/AT252463B/de active
- 1961-08-01 AT AT100362A patent/AT252462B/de active
- 1961-08-01 AT AT594961A patent/AT249274B/de active
- 1961-08-01 AT AT100062A patent/AT252459B/de active
- 1961-08-01 AT AT100162A patent/AT252460B/de active
- 1961-08-01 AT AT100262A patent/AT252461B/de active
- 1961-08-01 AT AT594861A patent/AT249273B/de active
- 1961-08-01 NL NL61267779A patent/NL139529B/xx unknown
- 1961-08-02 GB GB28118/61A patent/GB999392A/en not_active Expired
- 1961-08-02 SE SE7893/61A patent/SE301650B/xx unknown
- 1961-08-02 SE SE7892/61A patent/SE301478B/xx unknown
- 1961-08-02 GB GB46383/64A patent/GB999397A/en not_active Expired
- 1961-08-02 ES ES0269515A patent/ES269515A1/es not_active Expired
- 1961-08-02 GB GB49912/64A patent/GB999398A/en not_active Expired
- 1961-08-02 GB GB28117/61A patent/GB999391A/en not_active Expired
- 1961-08-02 GB GB52687/64A patent/GB999399A/en not_active Expired
- 1961-08-02 ES ES0269516A patent/ES269516A1/es not_active Expired
- 1961-08-02 GB GB28119/61A patent/GB999393A/en not_active Expired
- 1961-08-02 ES ES0269514A patent/ES269514A1/es not_active Expired
-
1965
- 1965-06-08 SE SE7480/65A patent/SE301485B/xx unknown
- 1965-06-08 SE SE7481/65A patent/SE301486B/xx unknown
- 1965-06-08 SE SE7479/65A patent/SE301484B/xx unknown
- 1965-06-08 SE SE7478/65A patent/SE301321B/xx unknown
- 1965-06-08 SE SE7482/65A patent/SE301487B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES269516A1 (es) | 1962-04-16 |
| CH407145A (de) | 1966-02-15 |
| AT252459B (de) | 1967-02-27 |
| SE301485B (enrdf_load_stackoverflow) | 1968-06-10 |
| GB999397A (en) | 1965-07-28 |
| GB999399A (en) | 1965-07-28 |
| SE301478B (enrdf_load_stackoverflow) | 1968-06-10 |
| AT252462B (de) | 1967-02-27 |
| ES269515A1 (es) | 1962-04-16 |
| CH407143A (de) | 1966-02-15 |
| SE301321B (enrdf_load_stackoverflow) | 1968-06-04 |
| SE301650B (enrdf_load_stackoverflow) | 1968-06-17 |
| CH407146A (de) | 1966-02-15 |
| GB999392A (en) | 1965-07-28 |
| GB999391A (en) | 1965-07-28 |
| SE301486B (enrdf_load_stackoverflow) | 1968-06-10 |
| CH398627A (de) | 1966-03-15 |
| CH398628A (de) | 1966-03-15 |
| AT249273B (de) | 1966-09-12 |
| CH410969A (de) | 1966-04-15 |
| ES269514A1 (es) | 1962-04-16 |
| GB999398A (en) | 1965-07-28 |
| CH416658A (de) | 1966-07-15 |
| SE301487B (enrdf_load_stackoverflow) | 1968-06-10 |
| AT249274B (de) | 1966-09-12 |
| AT252460B (de) | 1967-02-27 |
| AT252463B (de) | 1967-02-27 |
| NL139529B (nl) | 1973-08-15 |
| SE301484B (enrdf_load_stackoverflow) | 1968-06-10 |
| AT252461B (de) | 1967-02-27 |
| CH407144A (de) | 1966-02-15 |
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