GB976065A - Lumiergoline derivatives - Google Patents
Lumiergoline derivativesInfo
- Publication number
- GB976065A GB976065A GB2224363A GB2224363A GB976065A GB 976065 A GB976065 A GB 976065A GB 2224363 A GB2224363 A GB 2224363A GB 2224363 A GB2224363 A GB 2224363A GB 976065 A GB976065 A GB 976065A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carboxylic
- methyl
- lysergamide
- hydrogen atom
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of formula <FORM:0976065/C1/1> wherein R is a hydrogen atom or a methyl group and R1 is the group -CH2NHR11 in which R11 is a hydrogen atom or the radical of an aliphatic, cycloaliphatic, aromatic or heterocyclic carboxylic or sulphonic acid having 1 to 10 carbon atoms, optionally substituted by halogen atoms, free or alkylated amino-groups, nitro-, hydroxy, alkyl, alkoxy, phenoxy, thioether, carboxylic or sulphonic groups, and including alkoxycarbonyl and carbamoyl radicals, and their preparation by irradiating lysergamide or 1-methyl lysergamide with ultra-violet light in dilute aqueous organic acid solution to yield lumilysergamide or 1-methylumilysergamide, reducing the products thus obtained to the corresponding amine, and, if desired, reacting this with the chloride or anhydride of the appropriate carboxylic or sulphonic acid. Numerous acids are listed. 1-methylation may be effected before or after irradiation by reaction with a methyl halide in liquid ammonia and in the presence of metallic potassium. The compounds of the invention have oxytocic; antienteraminic, adrenolytic, hypotensive and sedative activity, and may be used in pharmaceutical compositions in combination with a therapeutically acceptable carrier in forms suitable for oral or parenteral administration, for example as tablets, powders, pills, capsules or liquids.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1158262 | 1962-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB976065A true GB976065A (en) | 1964-11-25 |
Family
ID=11135933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2224363A Expired GB976065A (en) | 1962-06-08 | 1963-06-04 | Lumiergoline derivatives |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH431548A (en) |
| ES (1) | ES288826A1 (en) |
| GB (1) | GB976065A (en) |
-
1963
- 1963-06-04 GB GB2224363A patent/GB976065A/en not_active Expired
- 1963-06-07 ES ES288826A patent/ES288826A1/en not_active Expired
- 1963-06-07 CH CH715863A patent/CH431548A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH431548A (en) | 1967-03-15 |
| ES288826A1 (en) | 1963-11-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB981827A (en) | Lumilysergol derivatives | |
| GB1069069A (en) | An aminoalkylethanoanthracene and process for its manufacture | |
| GB1425354A (en) | Indole derivatives | |
| GB1016071A (en) | New guanidine derivatives and process for preparing the same | |
| GB976065A (en) | Lumiergoline derivatives | |
| ES444927A1 (en) | 3-thiolated-7-acylamido-cephalosporanic acid derivatives processes for preparing them and pharmaceutical compositions 0mprising them | |
| ES417890A1 (en) | Penicillanic acid derivatives | |
| GB1004310A (en) | 1,6-dimethyl-ergoline i derivatives | |
| GB1060694A (en) | New derivatives of thiochromanes and a process for the preparation thereof | |
| DE3371904D1 (en) | Tryptamine derivatives active on the cardiovascular system, and process for their preparation | |
| GB1466462A (en) | Amines and process for their manufacture | |
| GB1112909A (en) | Ergoline derivatives | |
| GB1109690A (en) | 5-oxo-3,4,5,6-tetrahydro-1h-azepino[4,3,2-cd]indoles and the manufacture thereof | |
| GB863715A (en) | New acylpiperidines | |
| GB1022935A (en) | Derivatives of dihydro-d-lysergic acid | |
| GB899405A (en) | Aryl dicarboxylic acid imides and process for their manufacture | |
| GB999393A (en) | New ethers of the yohimbane series and process for their manufacture | |
| GB1088346A (en) | ª‡-aminocarboxylic acid esters and a process for their manufacture | |
| GB985004A (en) | 6-methyl-ergoline i derivatives | |
| GB1071558A (en) | Improvements in or relating to pyrido[3,4-b]indole derivatives | |
| GB1058403A (en) | Improvements in or relating to novel 4-aza-thiaxanthene derivatives | |
| GB849755A (en) | Pharmaceutical preparations comprising ª‡-dialkylamino-propiophenones | |
| GB834300A (en) | Improvements in and relating to quinoline derivatives and the manufacture thereof | |
| GB1111696A (en) | Method of preparing nitrogenous steroids | |
| GB994486A (en) | Improvements in or relating to lysergic acid amide derivatives |