GB998710A - Progesterone derivative and preparation thereof - Google Patents
Progesterone derivative and preparation thereofInfo
- Publication number
- GB998710A GB998710A GB14153/64A GB1415364A GB998710A GB 998710 A GB998710 A GB 998710A GB 14153/64 A GB14153/64 A GB 14153/64A GB 1415364 A GB1415364 A GB 1415364A GB 998710 A GB998710 A GB 998710A
- Authority
- GB
- United Kingdom
- Prior art keywords
- progesterone
- chloro
- ethoxy
- hydroxy
- dehydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000003145 progesterone derivatives Chemical class 0.000 title 1
- 238000006266 etherification reaction Methods 0.000 abstract 4
- 229960003387 progesterone Drugs 0.000 abstract 4
- 239000000186 progesterone Substances 0.000 abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 2
- 125000000468 ketone group Chemical group 0.000 abstract 2
- JERGUCIJOXJXHF-TVWVXWENSA-N 17alpha-hydroxypregnenolone Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 JERGUCIJOXJXHF-TVWVXWENSA-N 0.000 abstract 1
- YNJSNEKCXVFDKW-UHFFFAOYSA-N 3-(5-amino-1h-indol-3-yl)-2-azaniumylpropanoate Chemical compound C1=C(N)C=C2C(CC(N)C(O)=O)=CNC2=C1 YNJSNEKCXVFDKW-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- AHXGRMIPHCAXFP-UHFFFAOYSA-L chromyl dichloride Chemical compound Cl[Cr](Cl)(=O)=O AHXGRMIPHCAXFP-UHFFFAOYSA-L 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 238000006356 dehydrogenation reaction Methods 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 150000002084 enol ethers Chemical class 0.000 abstract 1
- 238000006735 epoxidation reaction Methods 0.000 abstract 1
- 230000006203 ethylation Effects 0.000 abstract 1
- 238000006200 ethylation reaction Methods 0.000 abstract 1
- 229960002899 hydroxyprogesterone Drugs 0.000 abstract 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 230000003204 osmotic effect Effects 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 239000000583 progesterone congener Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEM59457A DE1273528B (de) | 1964-01-03 | 1964-01-03 | 17ª‡-AEthoxy-6-chlor-6-dehydro-progesteron und Verfahren zur Herstellung desselben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB998710A true GB998710A (en) | 1965-07-21 |
Family
ID=7309533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB14153/64A Expired GB998710A (en) | 1964-01-03 | 1964-04-06 | Progesterone derivative and preparation thereof |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE645235A (enrdf_load_stackoverflow) |
| BR (1) | BR6459244D0 (enrdf_load_stackoverflow) |
| CH (3) | CH443289A (enrdf_load_stackoverflow) |
| DE (1) | DE1273528B (enrdf_load_stackoverflow) |
| DK (3) | DK106186C (enrdf_load_stackoverflow) |
| FR (1) | FR3411M (enrdf_load_stackoverflow) |
| GB (1) | GB998710A (enrdf_load_stackoverflow) |
| NL (1) | NL6402400A (enrdf_load_stackoverflow) |
| SE (1) | SE313561B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1359154A1 (en) * | 2002-04-29 | 2003-11-05 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Further syntheses of cyproterone acetate |
-
1964
- 1964-01-03 DE DEM59457A patent/DE1273528B/de active Pending
- 1964-01-31 CH CH966967A patent/CH443289A/de unknown
- 1964-01-31 CH CH967067A patent/CH443290A/de unknown
- 1964-01-31 CH CH114864A patent/CH441301A/de unknown
- 1964-03-09 NL NL6402400A patent/NL6402400A/xx unknown
- 1964-03-16 BE BE645235D patent/BE645235A/xx unknown
- 1964-04-06 GB GB14153/64A patent/GB998710A/en not_active Expired
- 1964-04-08 FR FR970149A patent/FR3411M/fr active Active
- 1964-05-18 BR BR15924464A patent/BR6459244D0/pt unknown
- 1964-05-22 DK DK256964A patent/DK106186C/da active
- 1964-05-22 DK DK225565A patent/DK107421C/da active
- 1964-05-22 DK DK225665A patent/DK108721C/da active
- 1964-05-25 SE SE629464A patent/SE313561B/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1359154A1 (en) * | 2002-04-29 | 2003-11-05 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Further syntheses of cyproterone acetate |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6402400A (enrdf_load_stackoverflow) | 1965-07-05 |
| DE1273528B (de) | 1968-07-25 |
| BE645235A (enrdf_load_stackoverflow) | 1964-09-16 |
| CH443290A (de) | 1967-09-15 |
| DK106186C (da) | 1967-01-02 |
| SE313561B (enrdf_load_stackoverflow) | 1969-08-18 |
| CH443289A (de) | 1967-09-15 |
| BR6459244D0 (pt) | 1973-08-09 |
| DK107421C (da) | 1967-05-29 |
| CH441301A (de) | 1967-08-15 |
| DK108721C (da) | 1968-02-05 |
| FR3411M (fr) | 1965-07-05 |
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