GB993595A - 3h pyrimido-[5,4-c]-1,2,5-oxadiazine derivatives - Google Patents
3h pyrimido-[5,4-c]-1,2,5-oxadiazine derivativesInfo
- Publication number
- GB993595A GB993595A GB1195263A GB1195263A GB993595A GB 993595 A GB993595 A GB 993595A GB 1195263 A GB1195263 A GB 1195263A GB 1195263 A GB1195263 A GB 1195263A GB 993595 A GB993595 A GB 993595A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- dimethyl
- nitrosation
- pyrimido
- uracils
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The invention comprises 3H - pyrimido-[5,4-c]-1,2,5-oxadiazines of the formula <FORM:0993595/C2/1> wherein R1 and R2, which may be the same or different, represent hydrogen atoms or straight or branched chain alkyl radicals and R3 and R4, which may be the same or different, are alkyl radicals or R3 and R4 may together form a cyclic radical and the preparation thereof by reaction of a compound of the formula <FORM:0993595/C2/2> with nitrous acid or an ester thereof, preferably at an elevated temperature or by a modification of the above process in which a 4-aminouracil of the formula <FORM:0993595/C2/3> is nitrosated with excess nitrosation agent to give the 5-nitrose compound which without isolation is cyclized by the action of excess nitrosation agent. 1,3 - Dimethyl - 8,8 - pentamethylene - 8H - xanthine - 7 - N - oxide is formed as an intermediate by the action of isoamyl nitrite on 1,3 - dimethyl - 4 - cyclohexylamino - 5 - nitrouracil or on 1,3-dimethyl-4-cyclohexylaminouracil. 5-Nitrosouracils of the Formula II where stable may be prepared by nitrosation of uracils of the Formula III. Uracils of the Formula III may be prepared by reaction of the appropriately 1,3-substituted 4-chlorouracils with amines of the formula <FORM:0993595/C2/4> or by transemination of the appropriately substituted 4-aminouracils with amine hydrochlorides of the formula <FORM:0993595/C2/5>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEV0028897 | 1965-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB993595A true GB993595A (en) | 1965-05-26 |
Family
ID=7584481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1195263A Expired GB993595A (en) | 1965-07-16 | 1963-03-26 | 3h pyrimido-[5,4-c]-1,2,5-oxadiazine derivatives |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE1620661A1 (en) |
GB (1) | GB993595A (en) |
-
1963
- 1963-03-26 GB GB1195263A patent/GB993595A/en not_active Expired
-
1965
- 1965-07-16 DE DE19651620661 patent/DE1620661A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE1620661A1 (en) | 1970-02-05 |
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