GB985658A - Benzophenones and the preparation thereof - Google Patents

Benzophenones and the preparation thereof

Info

Publication number
GB985658A
GB985658A GB1281964A GB1281964A GB985658A GB 985658 A GB985658 A GB 985658A GB 1281964 A GB1281964 A GB 1281964A GB 1281964 A GB1281964 A GB 1281964A GB 985658 A GB985658 A GB 985658A
Authority
GB
United Kingdom
Prior art keywords
carboxy
carbamyl
substituted
benzophenone
benzophenones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1281964A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US114038A external-priority patent/US3153082A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB985658A publication Critical patent/GB985658A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention comprises compounds of the formula <FORM:0985658/C2/1> wherein R1 and R2 each represent a halogen atom or an alkyl, alkoxy, alkylthio, nitro, trifluoromethyl, carboxy, alkoxycarbonyl, carbamyl or cyano group but at least one of which is a carboxy, alkoxycarbonyl, carbamyl or cyano group and wherein the broken lines denote that the groups attached thereby are optional. The carboxy substituted benzophenones may be prepared from the corresponding methyl substituted benzophenones and acylated to yield a methyl substituted 2-acetamido-benzophenone, which may be oxidized to a carboxy-substituted 2-acetamide benzophenone. The latter may be hydrolysed to a carboxy-substituted 2-amino benzophenone. The carboxy groups may be esterified, or converted to carbamyl by dehydration of the ammonium salt of the carboxylic acid. The carbamyl compounds may be converted to cyano derivaties by dehydration (e.g. by treatment with POCl3).
GB1281964A 1961-03-20 1962-03-16 Benzophenones and the preparation thereof Expired GB985658A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9666361A 1961-03-20 1961-03-20
US114038A US3153082A (en) 1961-06-01 1961-06-01 2-amino-benzophenones

Publications (1)

Publication Number Publication Date
GB985658A true GB985658A (en) 1965-03-10

Family

ID=26791934

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1281964A Expired GB985658A (en) 1961-03-20 1962-03-16 Benzophenones and the preparation thereof
GB1012062A Expired GB985657A (en) 1961-03-20 1962-03-16 Benzodiazepine derivatives and a process for the manufacture thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1012062A Expired GB985657A (en) 1961-03-20 1962-03-16 Benzodiazepine derivatives and a process for the manufacture thereof

Country Status (5)

Country Link
BE (1) BE615194A (en)
CH (2) CH459239A (en)
ES (1) ES275601A1 (en)
GB (2) GB985658A (en)
SE (1) SE301974B (en)

Also Published As

Publication number Publication date
SE301974B (en) 1968-07-01
CH459239A (en) 1968-07-15
BE615194A (en) 1962-09-17
CH445500A (en) 1967-10-31
DE1445858B2 (en) 1975-07-03
DE1445858A1 (en) 1969-01-16
GB985657A (en) 1965-03-10
ES275601A1 (en) 1962-09-16

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