GB985658A - Benzophenones and the preparation thereof - Google Patents
Benzophenones and the preparation thereofInfo
- Publication number
- GB985658A GB985658A GB1281964A GB1281964A GB985658A GB 985658 A GB985658 A GB 985658A GB 1281964 A GB1281964 A GB 1281964A GB 1281964 A GB1281964 A GB 1281964A GB 985658 A GB985658 A GB 985658A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carboxy
- carbamyl
- substituted
- benzophenone
- benzophenones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000012965 benzophenone Substances 0.000 title abstract 4
- 150000008366 benzophenones Chemical class 0.000 title abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 230000018044 dehydration Effects 0.000 abstract 2
- 238000006297 dehydration reaction Methods 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- 229910019213 POCl3 Inorganic materials 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 abstract 1
- -1 carboxy-substituted 2-amino benzophenone Chemical class 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- MRXZRJQRQWTKIX-UHFFFAOYSA-N n-(2-benzoylphenyl)acetamide Chemical class CC(=O)NC1=CC=CC=C1C(=O)C1=CC=CC=C1 MRXZRJQRQWTKIX-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention comprises compounds of the formula <FORM:0985658/C2/1> wherein R1 and R2 each represent a halogen atom or an alkyl, alkoxy, alkylthio, nitro, trifluoromethyl, carboxy, alkoxycarbonyl, carbamyl or cyano group but at least one of which is a carboxy, alkoxycarbonyl, carbamyl or cyano group and wherein the broken lines denote that the groups attached thereby are optional. The carboxy substituted benzophenones may be prepared from the corresponding methyl substituted benzophenones and acylated to yield a methyl substituted 2-acetamido-benzophenone, which may be oxidized to a carboxy-substituted 2-acetamide benzophenone. The latter may be hydrolysed to a carboxy-substituted 2-amino benzophenone. The carboxy groups may be esterified, or converted to carbamyl by dehydration of the ammonium salt of the carboxylic acid. The carbamyl compounds may be converted to cyano derivaties by dehydration (e.g. by treatment with POCl3).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9666361A | 1961-03-20 | 1961-03-20 | |
| US114038A US3153082A (en) | 1961-06-01 | 1961-06-01 | 2-amino-benzophenones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB985658A true GB985658A (en) | 1965-03-10 |
Family
ID=26791934
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1012062A Expired GB985657A (en) | 1961-03-20 | 1962-03-16 | Benzodiazepine derivatives and a process for the manufacture thereof |
| GB1281964A Expired GB985658A (en) | 1961-03-20 | 1962-03-16 | Benzophenones and the preparation thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1012062A Expired GB985657A (en) | 1961-03-20 | 1962-03-16 | Benzodiazepine derivatives and a process for the manufacture thereof |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE615194A (en) |
| CH (2) | CH445500A (en) |
| ES (1) | ES275601A1 (en) |
| GB (2) | GB985657A (en) |
| SE (1) | SE301974B (en) |
-
1962
- 1962-03-09 CH CH288462A patent/CH445500A/en unknown
- 1962-03-09 CH CH551966A patent/CH459239A/en unknown
- 1962-03-16 GB GB1012062A patent/GB985657A/en not_active Expired
- 1962-03-16 BE BE615194A patent/BE615194A/en unknown
- 1962-03-16 GB GB1281964A patent/GB985658A/en not_active Expired
- 1962-03-17 ES ES275601A patent/ES275601A1/en not_active Expired
- 1962-03-19 SE SE303062A patent/SE301974B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE301974B (en) | 1968-07-01 |
| DE1445858A1 (en) | 1969-01-16 |
| GB985657A (en) | 1965-03-10 |
| ES275601A1 (en) | 1962-09-16 |
| CH459239A (en) | 1968-07-15 |
| CH445500A (en) | 1967-10-31 |
| DE1445858B2 (en) | 1975-07-03 |
| BE615194A (en) | 1962-09-17 |
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