GB985658A - Benzophenones and the preparation thereof - Google Patents
Benzophenones and the preparation thereofInfo
- Publication number
- GB985658A GB985658A GB1281964A GB1281964A GB985658A GB 985658 A GB985658 A GB 985658A GB 1281964 A GB1281964 A GB 1281964A GB 1281964 A GB1281964 A GB 1281964A GB 985658 A GB985658 A GB 985658A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carboxy
- carbamyl
- substituted
- benzophenone
- benzophenones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention comprises compounds of the formula <FORM:0985658/C2/1> wherein R1 and R2 each represent a halogen atom or an alkyl, alkoxy, alkylthio, nitro, trifluoromethyl, carboxy, alkoxycarbonyl, carbamyl or cyano group but at least one of which is a carboxy, alkoxycarbonyl, carbamyl or cyano group and wherein the broken lines denote that the groups attached thereby are optional. The carboxy substituted benzophenones may be prepared from the corresponding methyl substituted benzophenones and acylated to yield a methyl substituted 2-acetamido-benzophenone, which may be oxidized to a carboxy-substituted 2-acetamide benzophenone. The latter may be hydrolysed to a carboxy-substituted 2-amino benzophenone. The carboxy groups may be esterified, or converted to carbamyl by dehydration of the ammonium salt of the carboxylic acid. The carbamyl compounds may be converted to cyano derivaties by dehydration (e.g. by treatment with POCl3).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9666361A | 1961-03-20 | 1961-03-20 | |
US114038A US3153082A (en) | 1961-06-01 | 1961-06-01 | 2-amino-benzophenones |
Publications (1)
Publication Number | Publication Date |
---|---|
GB985658A true GB985658A (en) | 1965-03-10 |
Family
ID=26791934
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1281964A Expired GB985658A (en) | 1961-03-20 | 1962-03-16 | Benzophenones and the preparation thereof |
GB1012062A Expired GB985657A (en) | 1961-03-20 | 1962-03-16 | Benzodiazepine derivatives and a process for the manufacture thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1012062A Expired GB985657A (en) | 1961-03-20 | 1962-03-16 | Benzodiazepine derivatives and a process for the manufacture thereof |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE615194A (en) |
CH (2) | CH459239A (en) |
ES (1) | ES275601A1 (en) |
GB (2) | GB985658A (en) |
SE (1) | SE301974B (en) |
-
1962
- 1962-03-09 CH CH551966A patent/CH459239A/en unknown
- 1962-03-09 CH CH288462A patent/CH445500A/en unknown
- 1962-03-16 GB GB1281964A patent/GB985658A/en not_active Expired
- 1962-03-16 BE BE615194A patent/BE615194A/en unknown
- 1962-03-16 GB GB1012062A patent/GB985657A/en not_active Expired
- 1962-03-17 ES ES275601A patent/ES275601A1/en not_active Expired
- 1962-03-19 SE SE303062A patent/SE301974B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
SE301974B (en) | 1968-07-01 |
CH459239A (en) | 1968-07-15 |
BE615194A (en) | 1962-09-17 |
CH445500A (en) | 1967-10-31 |
DE1445858B2 (en) | 1975-07-03 |
DE1445858A1 (en) | 1969-01-16 |
GB985657A (en) | 1965-03-10 |
ES275601A1 (en) | 1962-09-16 |
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