GB985498A - Improvements in or relating to plasmin preparations - Google Patents

Improvements in or relating to plasmin preparations

Info

Publication number
GB985498A
GB985498A GB15352/62A GB1535262A GB985498A GB 985498 A GB985498 A GB 985498A GB 15352/62 A GB15352/62 A GB 15352/62A GB 1535262 A GB1535262 A GB 1535262A GB 985498 A GB985498 A GB 985498A
Authority
GB
United Kingdom
Prior art keywords
amino
plasmin
acid
amino acid
millimole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB15352/62A
Other languages
English (en)
Inventor
Villy Johannes Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Terapeutisk Laboratorium AS
Original Assignee
Novo Terapeutisk Laboratorium AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Terapeutisk Laboratorium AS filed Critical Novo Terapeutisk Laboratorium AS
Publication of GB985498A publication Critical patent/GB985498A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
GB15352/62A 1961-04-25 1962-04-19 Improvements in or relating to plasmin preparations Expired GB985498A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK169161AA DK98833C (da) 1961-04-25 1961-04-25 Fremgangsmåde til stabilisering af terapeutisk anvendelige plasminopløsninger.

Publications (1)

Publication Number Publication Date
GB985498A true GB985498A (en) 1965-03-10

Family

ID=8107240

Family Applications (1)

Application Number Title Priority Date Filing Date
GB15352/62A Expired GB985498A (en) 1961-04-25 1962-04-19 Improvements in or relating to plasmin preparations

Country Status (9)

Country Link
BE (1) BE616779A (hu)
CH (1) CH456848A (hu)
DK (1) DK98833C (hu)
FI (1) FI43764B (hu)
FR (1) FR2140M (hu)
GB (1) GB985498A (hu)
NL (1) NL147634B (hu)
NO (1) NO123024B (hu)
SE (1) SE327779B (hu)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0217379A2 (en) * 1985-10-02 1987-04-08 Mochida Pharmaceutical Co., Ltd. Thrombolytic composition and a process for production thereof
DE3642960A1 (de) * 1985-12-17 1987-06-19 Genentech Inc Stabilisierte zusammensetzungen des menschlichen gewebe-plasminogen-aktivators
EP1545588A2 (en) * 2002-07-23 2005-06-29 Ludwig Institute For Cancer Research Methods and compositions for activating or inhibiting vegf-d and vegf-c
WO2006122249A2 (en) * 2005-05-11 2006-11-16 Bausch & Lomb Incorporated Use of plasmin for preventing of reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions
US7547435B2 (en) 2002-12-06 2009-06-16 Thrombogenics Nv Pharmacological vitreolysis
US7871608B2 (en) 1999-11-13 2011-01-18 Talecris Biotherapeutics, Inc. Reversibly inactivated acidified plasmin
US8268782B2 (en) 1999-11-13 2012-09-18 Grifols Therapeutics Inc. Composition and method for preparing plasminogen
US8617863B2 (en) 2008-06-04 2013-12-31 Grifols Therapeutics Inc. Composition, method, and kit for preparing plasmin
US9206410B2 (en) 2009-03-03 2015-12-08 Grifols Therapeutics Inc. Compositions, methods and kits for preparing plasminogen and plasmin prepared therefrom
CN106167797A (zh) * 2016-07-28 2016-11-30 武汉生物制品研究所有限责任公司 人纤维蛋白溶解酶原的冻干制剂及其制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2750159C3 (de) * 1977-11-09 1980-05-22 Lentia Gmbh, Chem. U. Pharm. Erzeugnisse - Industriebedarf, 8000 Muenchen Infusionslösung zur Behandlung von hepatischer Encephalopathie und ein Verfahren zu deren Herstellung

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0217379A2 (en) * 1985-10-02 1987-04-08 Mochida Pharmaceutical Co., Ltd. Thrombolytic composition and a process for production thereof
EP0217379A3 (en) * 1985-10-02 1988-08-31 Mochida Pharmaceutical Co., Ltd. Thrombolytic composition and a process for production thereof
DE3642960A1 (de) * 1985-12-17 1987-06-19 Genentech Inc Stabilisierte zusammensetzungen des menschlichen gewebe-plasminogen-aktivators
FR2591485A1 (fr) * 1985-12-17 1987-06-19 Genentech Inc Compositions stabilisees contenant l'activateur du plasminogene du tissu humain.
EP0228862A2 (en) * 1985-12-17 1987-07-15 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
EP0228862A3 (en) * 1985-12-17 1988-09-28 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US7871608B2 (en) 1999-11-13 2011-01-18 Talecris Biotherapeutics, Inc. Reversibly inactivated acidified plasmin
US9879246B2 (en) 1999-11-13 2018-01-30 Grifols Therapeutics Inc. Reversibly inactivated acidified plasmin composition
EP1232251B2 (en) † 1999-11-13 2017-05-17 Grifols Therapeutics Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US8268782B2 (en) 1999-11-13 2012-09-18 Grifols Therapeutics Inc. Composition and method for preparing plasminogen
EP1545588A2 (en) * 2002-07-23 2005-06-29 Ludwig Institute For Cancer Research Methods and compositions for activating or inhibiting vegf-d and vegf-c
US7479270B2 (en) 2002-07-23 2009-01-20 Vegenics Limited Methods and compositions for activating VEGF-D and VEGF-C
EP1545588A4 (en) * 2002-07-23 2007-12-05 Ludwig Inst Cancer Res METHODS AND COMPOSITIONS FOR ACTIVATION OR INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR D AND VASCULAR ENDOTHELIAL GROWTH FACTOR C
US7887800B2 (en) 2002-07-23 2011-02-15 Vegenics Limited Methods for inhibiting VEGF-D
US8747842B2 (en) 2002-12-06 2014-06-10 Thrombogenics Nv Pharmacological vitreolysis
US7547435B2 (en) 2002-12-06 2009-06-16 Thrombogenics Nv Pharmacological vitreolysis
US7914783B2 (en) 2002-12-06 2011-03-29 Thrombogenics Nv Pharmacological vitreolysis
US7803368B2 (en) 2002-12-06 2010-09-28 Thrombogenics Nv Pharmacological vitreolysis
US8383105B2 (en) 2002-12-06 2013-02-26 Thrombogenics Nv Pharmacological vitreolysis
US8460655B2 (en) 2002-12-06 2013-06-11 Thrombogenics Nv Pharmacological vitreolysis
US9770494B2 (en) 2002-12-06 2017-09-26 Thrombogenics Nv Pharmacological vitreolysis
US7867489B2 (en) 2002-12-06 2011-01-11 Thrombogenics Nv Pharmacological vitreolysis
US8834869B2 (en) 2002-12-06 2014-09-16 Thrombogenics Nv Pharmacological vitreolysis
US9186394B2 (en) 2002-12-06 2015-11-17 Thrombogenics Nv Pharmacological vitreolysis
WO2006122249A3 (en) * 2005-05-11 2007-06-07 Bausch & Lomb Use of plasmin for preventing of reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions
WO2006122249A2 (en) * 2005-05-11 2006-11-16 Bausch & Lomb Incorporated Use of plasmin for preventing of reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions
US8617863B2 (en) 2008-06-04 2013-12-31 Grifols Therapeutics Inc. Composition, method, and kit for preparing plasmin
US9206410B2 (en) 2009-03-03 2015-12-08 Grifols Therapeutics Inc. Compositions, methods and kits for preparing plasminogen and plasmin prepared therefrom
CN106167797A (zh) * 2016-07-28 2016-11-30 武汉生物制品研究所有限责任公司 人纤维蛋白溶解酶原的冻干制剂及其制备方法
CN106167797B (zh) * 2016-07-28 2019-04-09 国药集团武汉血液制品有限公司 人纤维蛋白溶解酶原的冻干制剂及其制备方法

Also Published As

Publication number Publication date
SE327779B (hu) 1970-08-31
CH456848A (fr) 1968-05-31
FR2140M (fr) 1963-11-12
NO123024B (hu) 1971-09-20
DK98833C (da) 1964-05-25
FI43764B (hu) 1971-03-01
BE616779A (fr) 1962-10-24
NL147634B (nl) 1975-11-17

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