GB980878A - Condensation products of tetracyclines, preparations containing them and process of preparing them - Google Patents
Condensation products of tetracyclines, preparations containing them and process of preparing themInfo
- Publication number
- GB980878A GB980878A GB5156/61A GB515661A GB980878A GB 980878 A GB980878 A GB 980878A GB 5156/61 A GB5156/61 A GB 5156/61A GB 515661 A GB515661 A GB 515661A GB 980878 A GB980878 A GB 980878A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- compounds
- tetracycline
- hydrogen atom
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to tetracycline compounds of the general formula <FORM:0980878/C2/1> or <FORM:0980878/C2/2> in which R1 represents a hydrogen, chlorine or bromine atom, R2 represents a hydrogen atom or a methyl group, R3, R4 and R6 each represents a hydrogen atom or a hydroxyl group, R5 represents a hydrogen atom, a dimethylamino group or a quaternised dimethylamino group and R7 represents a trichloromethyl, tribromomethyl or a trifluoromethyl group, or a 4- or 5a-epi-isomer thereof or the 12a desoxy or 5a (11a)-dehydro derivative of a compound having the formula of tetracycline, 5-hydroxytetracycline, 7 - chlorotetracycline or 7 - bromotetracycline but in which the 2-carboxamido group is replaced by a group of the formula <FORM:0980878/C2/3> R7 having the meaning given above or physiologically tolerable salts of said compounds with a base. These compounds are prepared by reacting the corresponding tetracycline which contains no substituents on the nitrogen atom of the 2-carboxamido group or a physiologically tolerable salt thereof with a base, with trichloro, tribromo, or trifluoro acetaldehyde. The compounds may be used in pharmaceutical compositions, e.g. in the form of an injectable solution, a depository preparation or a food preparation. Specification 872,991 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEF30505A DE1104951B (en) | 1960-02-10 | 1960-02-10 | Process for the production of condensation products of tetracyclines or their salts |
Publications (1)
Publication Number | Publication Date |
---|---|
GB980878A true GB980878A (en) | 1965-01-20 |
Family
ID=7093791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5156/61A Expired GB980878A (en) | 1960-02-10 | 1961-02-10 | Condensation products of tetracyclines, preparations containing them and process of preparing them |
Country Status (3)
Country | Link |
---|---|
CH (1) | CH390241A (en) |
DE (1) | DE1104951B (en) |
GB (1) | GB980878A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1038347A (en) * | 1964-05-08 | 1966-08-10 | Rit Rech Ind Therapeut | 2-carboxamido-substituted tetracyclines |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1068701B (en) * | 1959-11-12 | Bristol Laboratories Inc., East Syracuse, N. Y. (V. St. A.) | Process for the preparation of antibiotic tetracycline sodium hexametaphosphate | |
DE1033657B (en) * | 1956-07-07 | 1958-07-10 | Hoechst Ag | Process for the preparation of tetracycline salts which are sparingly soluble in water |
-
1960
- 1960-02-10 DE DEF30505A patent/DE1104951B/en active Pending
-
1961
- 1961-02-06 CH CH136961A patent/CH390241A/en unknown
- 1961-02-10 GB GB5156/61A patent/GB980878A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE1104951B (en) | 1961-04-20 |
CH390241A (en) | 1965-04-15 |
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