GB873316A - Optically active 3-mercapto-phenthiazine derivatives - Google Patents

Optically active 3-mercapto-phenthiazine derivatives

Info

Publication number
GB873316A
GB873316A GB2093658A GB2093658A GB873316A GB 873316 A GB873316 A GB 873316A GB 2093658 A GB2093658 A GB 2093658A GB 2093658 A GB2093658 A GB 2093658A GB 873316 A GB873316 A GB 873316A
Authority
GB
United Kingdom
Prior art keywords
optically active
general formula
hydrogen atom
isomers
action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2093658A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB873316A publication Critical patent/GB873316A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention comprises optically active forms of compounds of the general formula <FORM:0873316/IV (b)/1> (wherein R1 represents a hydrogen atom or a C1-C5 alkyl group and R2 a hydrogen atom or a C1-C4 alkyl group, and wherein the asymmetric carbon atom is marked +) and certain of their acid addition salts, and the preparation thereof by resolving the corresponding racemic compounds with the aid of optically active acids, or (when neither R1 nor R2 represents a hydrogen atom) by reacting a phenthiazine of the general formula <FORM:0873316/IV (b)/2> (wherein R11 represents a C1-C5 alky group) with an optically active piperidine derivative of the general formula <FORM:0873316/IV (b)/3> (wherein R12 represents a C1-C4 alky group). The products are useful as spasmolytic, histaminolytic, sympathicolytic, adrenolytic and sedative agents and as potentiators of anaesthetics, the (+)-isomers being stronger but the (-)-isomers more specific in their action. Optically active piperidine halides of the third general formula above are prepared by the action of halogenating agents on the corresponding optically active piperidine alcohols obtained by resolution of the racemic forms thereof. Specifications 863,547 and 863,551 also are referred to.
GB2093658A 1957-07-31 1958-06-30 Optically active 3-mercapto-phenthiazine derivatives Expired GB873316A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH4902857A CH368176A (en) 1957-07-31 1957-07-31 Process for the production of previously unknown, optically active sulfur-containing phenothiazines

Publications (1)

Publication Number Publication Date
GB873316A true GB873316A (en) 1961-07-19

Family

ID=4516584

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2093658A Expired GB873316A (en) 1957-07-31 1958-06-30 Optically active 3-mercapto-phenthiazine derivatives

Country Status (6)

Country Link
BE (1) BE569809A (en)
CH (1) CH368176A (en)
DE (1) DE1134078B (en)
FR (1) FR1212806A (en)
GB (1) GB873316A (en)
NL (1) NL105360C (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8623864B2 (en) 2003-11-13 2014-01-07 Noa Sic Aps Thioridazine and derivatives thereof for reversing anti-microbial drug-resistance
US9198916B1 (en) 2014-05-27 2015-12-01 B&G Partners, Llc Compounds and methods for treating tumors
US10888568B2 (en) 2014-04-28 2021-01-12 National Yang Ming University Pharmaceutical composition for treatment of cancer using phenothiazine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL95120C (en) * 1954-07-23

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8623864B2 (en) 2003-11-13 2014-01-07 Noa Sic Aps Thioridazine and derivatives thereof for reversing anti-microbial drug-resistance
US10888568B2 (en) 2014-04-28 2021-01-12 National Yang Ming University Pharmaceutical composition for treatment of cancer using phenothiazine
US9198916B1 (en) 2014-05-27 2015-12-01 B&G Partners, Llc Compounds and methods for treating tumors

Also Published As

Publication number Publication date
CH368176A (en) 1963-03-31
NL105360C (en)
DE1134078B (en) 1962-08-02
BE569809A (en)
FR1212806A (en) 1960-03-25

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