ES467566A1 - Preparation of isobutyramide derivatives - Google Patents
Preparation of isobutyramide derivativesInfo
- Publication number
- ES467566A1 ES467566A1 ES467566A ES467566A ES467566A1 ES 467566 A1 ES467566 A1 ES 467566A1 ES 467566 A ES467566 A ES 467566A ES 467566 A ES467566 A ES 467566A ES 467566 A1 ES467566 A1 ES 467566A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- isobutyramide
- derivatives
- preparation
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
The derivatives of isobutyramide represented by the formula (I) < IMAGE > in which R1 is a halogen atom and n is an integer from 2 to 6, are prepared by reacting, in dioxane, the substituted phenoxyisobutyramide of formula: < IMAGE > with the N-cyanoalkylene of formula CH2=CH-(CH2)p-CN, in which p is an integer from 0 to 4, in the presence of a basic agent and at a temperature of between 50 and 65 DEG C. The compounds of formula (I) can be used as active substances, in combination with an excipient suited for the method of administration, in medicinal compositions, especially those having hypolipaemiating and hypotriglyceridaemiating and hypocholesterolaemiating actions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB10069/77A GB1557420A (en) | 1977-03-10 | 1977-03-10 | Preparation of isobutyramide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES467566A1 true ES467566A1 (en) | 1978-10-16 |
Family
ID=9960874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES467566A Expired ES467566A1 (en) | 1977-03-10 | 1978-03-04 | Preparation of isobutyramide derivatives |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS53112823A (en) |
| AR (1) | AR214560A1 (en) |
| AT (1) | AT352104B (en) |
| AU (1) | AU517807B2 (en) |
| BE (1) | BE864075A (en) |
| CH (1) | CH628321A5 (en) |
| DE (1) | DE2810505C3 (en) |
| DK (1) | DK105078A (en) |
| EG (1) | EG13580A (en) |
| ES (1) | ES467566A1 (en) |
| FI (1) | FI780472A (en) |
| FR (1) | FR2383167A1 (en) |
| GB (1) | GB1557420A (en) |
| HK (1) | HK28880A (en) |
| IE (1) | IE46671B1 (en) |
| IN (1) | IN147801B (en) |
| LU (1) | LU79195A1 (en) |
| MX (1) | MX4826E (en) |
| MY (1) | MY8100067A (en) |
| NL (1) | NL7802024A (en) |
| NO (1) | NO143969C (en) |
| NZ (1) | NZ186388A (en) |
| OA (1) | OA05902A (en) |
| PT (1) | PT67667B (en) |
| SE (1) | SE431202B (en) |
| ZA (1) | ZA78618B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE496032T1 (en) | 1999-02-24 | 2011-02-15 | Hoffmann La Roche | 4-PHENYLPYRIDINE DERIVATIVES AND THEIR USE AS NK-1 RECEPTOR ANTAGONISTS |
| TWI280239B (en) | 2003-07-15 | 2007-05-01 | Hoffmann La Roche | Process for preparation of pyridine derivatives |
| DK1928427T3 (en) | 2005-09-23 | 2010-03-08 | Hoffmann La Roche | Hitherto unknown dosage formulation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE734725C (en) * | 1940-04-17 | 1943-04-30 | Ig Farbenindustrie Ag | Process for the preparation of formylamino-ª ‰ -propionitriles |
| GB1064252A (en) * | 1963-09-19 | 1967-04-05 | Ici Ltd | Amides and pharmaceutical compositions containing them |
| GB1041982A (en) * | 1963-09-30 | 1966-09-07 | Boots Pure Drug Co Ltd | Herbicidal compounds and compositions |
-
1977
- 1977-03-10 GB GB10069/77A patent/GB1557420A/en not_active Expired
-
1978
- 1978-02-01 ZA ZA00780618A patent/ZA78618B/en unknown
- 1978-02-06 IN IN94/DEL/78A patent/IN147801B/en unknown
- 1978-02-07 NZ NZ186388A patent/NZ186388A/en unknown
- 1978-02-14 FI FI780472A patent/FI780472A/en not_active Application Discontinuation
- 1978-02-16 PT PT67667A patent/PT67667B/en unknown
- 1978-02-17 BE BE185268A patent/BE864075A/en not_active IP Right Cessation
- 1978-02-21 AU AU33459/78A patent/AU517807B2/en not_active Expired
- 1978-02-23 NL NL7802024A patent/NL7802024A/en unknown
- 1978-02-24 CH CH200778A patent/CH628321A5/en not_active IP Right Cessation
- 1978-02-28 JP JP2168278A patent/JPS53112823A/en active Granted
- 1978-03-02 AT AT148978A patent/AT352104B/en not_active IP Right Cessation
- 1978-03-04 ES ES467566A patent/ES467566A1/en not_active Expired
- 1978-03-06 OA OA56427A patent/OA05902A/en unknown
- 1978-03-07 EG EG156/78A patent/EG13580A/en active
- 1978-03-08 AR AR271358A patent/AR214560A1/en active
- 1978-03-08 LU LU79195A patent/LU79195A1/en unknown
- 1978-03-09 IE IE483/78A patent/IE46671B1/en unknown
- 1978-03-09 MX MX786923U patent/MX4826E/en unknown
- 1978-03-09 NO NO780834A patent/NO143969C/en unknown
- 1978-03-09 SE SE7802694A patent/SE431202B/en unknown
- 1978-03-09 DK DK105078A patent/DK105078A/en not_active Application Discontinuation
- 1978-03-10 FR FR7806912A patent/FR2383167A1/en active Granted
- 1978-03-10 DE DE2810505A patent/DE2810505C3/en not_active Expired
-
1980
- 1980-05-22 HK HK288/80A patent/HK28880A/en unknown
-
1981
- 1981-12-30 MY MY67/81A patent/MY8100067A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IN147801B (en) | 1980-06-28 |
| OA05902A (en) | 1981-05-31 |
| SE431202B (en) | 1984-01-23 |
| PT67667A (en) | 1978-03-01 |
| NZ186388A (en) | 1979-04-26 |
| HK28880A (en) | 1980-05-30 |
| ATA148978A (en) | 1979-02-15 |
| MX4826E (en) | 1982-10-21 |
| FR2383167A1 (en) | 1978-10-06 |
| AR214560A1 (en) | 1979-06-29 |
| AU517807B2 (en) | 1981-08-27 |
| NO143969B (en) | 1981-02-09 |
| JPS5715831B2 (en) | 1982-04-01 |
| FI780472A (en) | 1978-09-11 |
| AT352104B (en) | 1979-09-10 |
| NO143969C (en) | 1981-06-03 |
| NO780834L (en) | 1978-09-12 |
| MY8100067A (en) | 1981-12-31 |
| NL7802024A (en) | 1978-09-12 |
| BE864075A (en) | 1978-06-16 |
| FR2383167B1 (en) | 1980-04-25 |
| SE7802694L (en) | 1978-09-11 |
| EG13580A (en) | 1981-12-31 |
| AU3345978A (en) | 1979-08-30 |
| CH628321A5 (en) | 1982-02-26 |
| JPS53112823A (en) | 1978-10-02 |
| DK105078A (en) | 1978-09-11 |
| ZA78618B (en) | 1978-12-27 |
| DE2810505B2 (en) | 1979-08-30 |
| IE780483L (en) | 1978-09-10 |
| IE46671B1 (en) | 1983-08-24 |
| DE2810505C3 (en) | 1980-05-08 |
| GB1557420A (en) | 1979-12-12 |
| LU79195A1 (en) | 1978-06-28 |
| PT67667B (en) | 1979-07-20 |
| DE2810505A1 (en) | 1978-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES483767A1 (en) | Alpha-(N-arylsulfonyl-L-argininamides, processes for their preparation and pharmaceutical compositions containing these substances. | |
| SE7614258L (en) | PROCEDURE FOR THE PREPARATION OF CHINAZOLO DERIVATIVE | |
| DE3271269D1 (en) | Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same | |
| ES8101068A1 (en) | Amino-pyrimidine-carbanilides, process for their preparation, medicines containing them. | |
| NO149888C (en) | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 2-SUBSTITUTED-2`-HYDROXYL-6,7-BENZOMORPHANES AND ACID ADDITION SALTS THEREOF | |
| ES462065A1 (en) | Thiazolidine derivatives | |
| ES482918A1 (en) | Indanyl derivatives, process for their preparation and pharmaceutical compositions containing these compounds. | |
| PT65697B (en) | PROCEDE POUR THE PREPARATION OF STEROIDES AVEC DES ANNEAUX TO 15 ATOMES OF CARBONE | |
| ES405983A1 (en) | N-fluoroalkylated phenylethylamine | |
| ATE2265T1 (en) | SECONDARY AMINES, THEIR PRODUCTION AND USE IN PHARMACEUTICAL COMPOSITIONS. | |
| ES8504738A1 (en) | Mercapto-imidazole derivatives, their preparation, mercapto-imidazole derivatives for the treatment of inflammatory diseases and their pharmaceutical compositions. | |
| DE3170937D1 (en) | 2-(1,4-benzodioxan-2-ylalkyl) imidazoles, their preparation and pharmaceutical compositions containing them | |
| ES455691A1 (en) | N-Benzhydryl-3-methyl-3-(dialkoxy)benzyl-piperazines | |
| ES467566A1 (en) | Preparation of isobutyramide derivatives | |
| ES480112A1 (en) | Derivatives of 2-imino-imidazolidine, processes for their preparation, pharmaceutical compositions containing them and intermediates. | |
| ES472276A1 (en) | Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them | |
| ES8200648A2 (en) | Ionic polyiodo benzene derivatives useful as X-ray contrast media | |
| ES466493A1 (en) | 4-phenylbutyric acid dervatives process for their preparation and pharmaceutical compostions containing them | |
| ES435361A1 (en) | 2-Methyl-1-(substituted)phenyl-2-propyl esters of 2-aminopropanoic acid | |
| ES439261A1 (en) | 5-(2-Hydroxypropoxy)-8-propyl-4H-1-benzopyran-4-one-2-carboxylic acid | |
| JPS5225740A (en) | Preparation of o-acyl-amidinophenols or acid addition salts thereof | |
| ES486049A1 (en) | Aminopropanol derivatives of 6-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-2-ones, process for their preparation, and pharmaceutical compositions containing them. | |
| IL60176A (en) | (aminopiperidinopropyl)dimethyl xanthine derivatives,processes for the preparation thereof and pharmaceutical compositions containing them | |
| DE3068274D1 (en) | Corticoid-17-thioacetals, their preparation and use | |
| CH609331A5 (en) | Process for the preparation of 3-aryloxy-3-phenyl-propylamines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19981103 |