GB976728A - Novel steroid compounds and their preparation - Google Patents

Novel steroid compounds and their preparation

Info

Publication number
GB976728A
GB976728A GB841664A GB841664A GB976728A GB 976728 A GB976728 A GB 976728A GB 841664 A GB841664 A GB 841664A GB 841664 A GB841664 A GB 841664A GB 976728 A GB976728 A GB 976728A
Authority
GB
United Kingdom
Prior art keywords
general formula
preparation
androst
methyl
subjected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB841664A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR828678A external-priority patent/FR1360155A/en
Priority claimed from FR851255A external-priority patent/FR1366725A/en
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB976728A publication Critical patent/GB976728A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 9b , 10a -19-norandrost-4-en-3-one derivatives of the general formula <FORM:0976728/C1/1> in which R is a hydrogen atom or an acyl radical, and a process for the preparation thereof in which a 3-alkoxy-3-methyl-19-nor-4-oxa-9b -androst-5(10)-ene of the general formula <FORM:0976728/C1/2> (wherein R is as defined above and R1 is a lower alkyl group) is subjected to treatment with a strong acid, e.g. HCl, or alternatively a 3-methyl-7-keto-8-(g -ketobutyl)-3,4-[31-acyloxy -cyclopentano-(21, 11)]-decahydronaphthalene of the general formula <FORM:0976728/C1/3> wherein Ac represents an acyl radical, is subjected to treatment with an alkaline dehydrating agent at elevated temperature to yield the 17b -hydroxy-9b , 10a -19-nor-androst-4-en-3-one as a secondary product, which is isolated by chromatographic separation, and fractional crystallization and optionally thereafter acylated at the 17-position. Specification 914,733 also is referred to.
GB841664A 1960-05-31 1961-05-31 Novel steroid compounds and their preparation Expired GB976728A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR828678A FR1360155A (en) 1960-05-31 1960-05-31 Process for preparing 19-nor-testosterone and compounds used in this process
FR851255A FR1366725A (en) 1961-01-31 1961-01-31 New oxa-steroids, their preparation and use in steroid synthesis

Publications (1)

Publication Number Publication Date
GB976728A true GB976728A (en) 1964-12-02

Family

ID=26186220

Family Applications (1)

Application Number Title Priority Date Filing Date
GB841664A Expired GB976728A (en) 1960-05-31 1961-05-31 Novel steroid compounds and their preparation

Country Status (2)

Country Link
DK (1) DK104623C (en)
GB (1) GB976728A (en)

Also Published As

Publication number Publication date
DK104623C (en) 1966-06-13

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