GB914738A - Improvements in or relating to processes for the production of compounds useful in steroid synthesis - Google Patents
Improvements in or relating to processes for the production of compounds useful in steroid synthesisInfo
- Publication number
- GB914738A GB914738A GB244661A GB244661A GB914738A GB 914738 A GB914738 A GB 914738A GB 244661 A GB244661 A GB 244661A GB 244661 A GB244661 A GB 244661A GB 914738 A GB914738 A GB 914738A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- compounds
- alkenyl
- androst
- seco
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 4,5-seco-19-nor-androst-9(11)-ene-3,5-dione compounds of the general formula:- <FORM:0914738/IV (b)/1> and the corresponding 3-monoketals, particularly the 3-ethylene ketal, in which R represents an alkyl group or an alkenyl group of from one to six carbon atoms and Ac represents an acyl radical, also the 3-monoketals of 17b -acyloxy-4,5-seco-19-nor-androst-9-ene-5-one, and processes for the preparation (a) of compounds of the above general formula by protecting the 3-ketone group of a 17b -acyloxy - 4,5 - seco - 19 - nor-androst-9-ene-3,5-dione, reacting the product with an alkyl or alkenyl halide and subsequently liberating the 3-keto group, and (b) of 9(11)-dehydro-testosterone or its 10b -alkyl or alkenyl homologues by simultaneously cyclizing and saponifying said compounds of the above general formula by subjecting them to the action of an alkali metal base. Detailed examples illustrate the invention, and a synthesis of cortisone and its 10b -alkyl and alkenyl analogues from the new compounds is outlined. Specifications 914,732 and 914,733 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR816401A FR1255101A (en) | 1960-01-22 | 1960-01-22 | Process for alkylating intermediates in the synthesis of 10-alkyl 19-nor steroids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB914738A true GB914738A (en) | 1963-01-02 |
Family
ID=8724179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB244661A Expired GB914738A (en) | 1960-01-22 | 1961-01-20 | Improvements in or relating to processes for the production of compounds useful in steroid synthesis |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE599341A (en) |
| CH (1) | CH394195A (en) |
| FR (1) | FR1255101A (en) |
| GB (1) | GB914738A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4158012A (en) * | 1978-06-19 | 1979-06-12 | Syntex (U.S.A.) Inc. | Steroid synthesis process using mixed anhydride |
-
1960
- 1960-01-22 FR FR816401A patent/FR1255101A/en not_active Expired
-
1961
- 1961-01-10 CH CH24961A patent/CH394195A/en unknown
- 1961-01-20 BE BE599341A patent/BE599341A/en unknown
- 1961-01-20 GB GB244661A patent/GB914738A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH394195A (en) | 1965-06-30 |
| FR1255101A (en) | 1961-03-03 |
| BE599341A (en) | 1961-07-20 |
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