GB975706A - N-substituted derivatives of 2-amino-1-(2,5-dimethoxy-phenyl)propan-1-ol - Google Patents

N-substituted derivatives of 2-amino-1-(2,5-dimethoxy-phenyl)propan-1-ol

Info

Publication number
GB975706A
GB975706A GB26628/61A GB2662861A GB975706A GB 975706 A GB975706 A GB 975706A GB 26628/61 A GB26628/61 A GB 26628/61A GB 2662861 A GB2662861 A GB 2662861A GB 975706 A GB975706 A GB 975706A
Authority
GB
United Kingdom
Prior art keywords
compounds
aqueous
propan
amino
amines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB26628/61A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB26628/61A priority Critical patent/GB975706A/en
Priority to ES0279237A priority patent/ES279237A1/en
Priority to CH856362A priority patent/CH414675A/en
Priority to DE19621518436 priority patent/DE1518436C/en
Priority to DK325262AA priority patent/DK103672C/en
Priority to AT587262A priority patent/AT241434B/en
Priority to FR912500A priority patent/FR2864M/en
Publication of GB975706A publication Critical patent/GB975706A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0975706/C1/1> (wherein the radical -CHRR1 is a secondary saturated hydrocarbon radical, including cycloalkyl), and acid addition salts thereof, their preparation by catalytically hydrogenating a solution containing 2-amino-1-(2, 5-dimethoxyphenyl)-propan-1-ol as the base together with a ketone of the formula O:CRR1, optionally followed by acid addition salt formation, and pharmaceutical preparations containing them together with a carrier. The invention includes the racemic and optically active erythro and threo forms of the compounds, and erythro amines may be converted into the corresponding threo amines by heating an N-acyl derivative (e.g. the acetyl or an aroyl derivative) with a dilute aqueous acid. The compounds of the invention block cardiac arrhythmias of sympathetic origin and interfere with the effects of adrenergic drugs, and may be administered in the form of pharmaceutical preparations (e.g. tablets, capsules, cachets, ampoules, suppositories, powders, granules, ointments and solutions and suspensions in aqueous, non-aqueous and emulsified liquids) containing them together with a carrier.
GB26628/61A 1961-07-21 1961-07-21 N-substituted derivatives of 2-amino-1-(2,5-dimethoxy-phenyl)propan-1-ol Expired GB975706A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GB26628/61A GB975706A (en) 1961-07-21 1961-07-21 N-substituted derivatives of 2-amino-1-(2,5-dimethoxy-phenyl)propan-1-ol
ES0279237A ES279237A1 (en) 1961-07-21 1962-07-14 N-substituted derivatives of 2-amino-1-(2,5-dimethoxy-phenyl)propan-1-ol
CH856362A CH414675A (en) 1961-07-21 1962-07-17 Process for the preparation of N-substituted derivatives of 2-amino-1- (2,5-dimethoxyphenyl) -propan-1-ol
DE19621518436 DE1518436C (en) 1961-07-21 1962-07-20 Phenylalkanolamines and their acid addition salts, processes for their manufacture and pharmaceuticals
DK325262AA DK103672C (en) 1961-07-21 1962-07-20 Process for the preparation of phenylpropanolamines or acid addition salts thereof.
AT587262A AT241434B (en) 1961-07-21 1962-07-20 Process for the preparation of new N-substituted 1- (2 ', 5'-dimethoxyphenyl) -2-aminopropanols
FR912500A FR2864M (en) 1961-07-21 1962-10-17 Medicament based on an n-substituted derivative of 2-amino-1- (2.5-dimethoxyphenyl) propan-1-ol, which can be used in particular as a pharmacodynamic agent.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB26628/61A GB975706A (en) 1961-07-21 1961-07-21 N-substituted derivatives of 2-amino-1-(2,5-dimethoxy-phenyl)propan-1-ol

Publications (1)

Publication Number Publication Date
GB975706A true GB975706A (en) 1964-11-18

Family

ID=10246635

Family Applications (1)

Application Number Title Priority Date Filing Date
GB26628/61A Expired GB975706A (en) 1961-07-21 1961-07-21 N-substituted derivatives of 2-amino-1-(2,5-dimethoxy-phenyl)propan-1-ol

Country Status (6)

Country Link
AT (1) AT241434B (en)
CH (1) CH414675A (en)
DK (1) DK103672C (en)
ES (1) ES279237A1 (en)
FR (1) FR2864M (en)
GB (1) GB975706A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102976961A (en) * 2012-12-24 2013-03-20 武汉武药制药有限公司 Method for preparing methoxamine hydrochloride

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2555574B2 (en) * 1979-07-13 1986-11-14 Lafon Labor 2-AMINO-1- (METHOXYPHENYL) -1-ETHANOL DERIVATIVES USEFUL AS MEDICAMENTS
GB0501580D0 (en) * 2005-01-25 2005-03-02 Norgine Europe Bv Compounds for treating urinary incontinence

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102976961A (en) * 2012-12-24 2013-03-20 武汉武药制药有限公司 Method for preparing methoxamine hydrochloride
CN102976961B (en) * 2012-12-24 2014-09-24 武汉武药制药有限公司 Method for preparing methoxamine hydrochloride

Also Published As

Publication number Publication date
ES279237A1 (en) 1963-01-01
FR2864M (en) 1964-10-26
DE1518436A1 (en) 1969-10-23
CH414675A (en) 1966-06-15
DK103672C (en) 1966-02-07
AT241434B (en) 1965-07-26

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