GB974522A - Pharmaceutical compositions for the treatment of coronary artery disease - Google Patents
Pharmaceutical compositions for the treatment of coronary artery diseaseInfo
- Publication number
- GB974522A GB974522A GB1354/62A GB135462A GB974522A GB 974522 A GB974522 A GB 974522A GB 1354/62 A GB1354/62 A GB 1354/62A GB 135462 A GB135462 A GB 135462A GB 974522 A GB974522 A GB 974522A
- Authority
- GB
- United Kingdom
- Prior art keywords
- naphthyl
- radical
- stands
- carbon atoms
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
974,522. Pharmaceutical compositions for the treatment of coronary artery disease. IMPERIAL CHEMICAL INDUSTRIES Ltd. Dec. 17, 1962 [Jan. 15, 1962], No. 1354/6.2. Heading A5B. Pharmaceutical compositions possessing #- adrenergic blocking activity contain as active ingredient at least one compound of the formula wherein R stands for hydrogen or for a lower alkyl radical containing not more than 5 carbon atoms, and R<SP>1</SP> stands for hydrogen when R<SP>2</SP> stands for hydrogen or an unbranched alkyl radical containing not more than 4 carbon atoms or for a benzyl radical, a #-phenylethyl radical, a cyclohexyl radical, or a 1,2,3;4-tetrahydro-2- naphthyl radical, or R<SP>1</SP> stands for a methyl radical when R<SP>2</SP> stands for an unbranched alkyl radical containing not more than 4 carbon atoms, or for a branched alkyl radical containing 3 or 4 carbon atoms, or a benzyl radical, a #- phenylethyl radical, a cyclohexyl radical, or a 1,2,3,4-tetrahydro-2-naphthyl radical, or R<SP>1</SP> stands for a branched or unbranched alkyl radical containing 2, 3 or 4 carbon atoms when R<SP>2</SP> stands for an alkyl radical containing 2, 3 or 4 carbon atoms, or R<SP>1</SP> and R<SP>2</SP>, together with the adjacent nitrogen atom, form a heterocyclic ring and wherein the naphthalene nucleus may optionally bear one or more additional substituents, or a pharmaceutically-acceptable salt thereof, in admixture with one or more pharmaceutically-acceptable diluents or carriers therefor. The optional substituents in the naphthalene nucleus may be halogen and lower alkyl and alkoxy radicals containing not more than 5 carbon atoms. The active salts may be derived from hydrochloric, hydrobromic, phosphoric, sulphuric, oxalic, lactic, tartaric, acetic, salicylic and citric acids. Active ingredients specified are 1-(21-naphthyl)-2-amino-, 1-(2<SP>1</SP>- naphthyl) - 2 - methylamino-, 1 - (2<SP>1</SP>- naphthyl)- 2 - ethylamino-, 1 - (2<SP>1</SP>- naphthyl) - 2 - n - propylamino-, 1 - (2<SP>1 </SP>- naphthyl) - 2 - n - butylamino-, 1 - (2<SP>1</SP> - naphthyl) - 2 - cyclohexylamino-, 1-(21- naphthyl) - 2 - dimethylamino- and 1 - (2<SP>1</SP>-naphthyl) - 2 - di - isopropylamino - ethanol, 1 - (2<SP>1</SP>- naphthyl) - 2 - piperidinoethanol, 1 - (2<SP>1 </SP>- naphthyl) - 2 - aminopropanol, 1 - (2<SP>1</SP> - naphthyl)-2- benzylaminoethanol, 1 - (2<SP>1</SP> - naphthyl) - 2 - (2<SP>1</SP>- phenylethylamino) - ethanol, 1 - (2<SP>1 </SP>- naphthyl)- 2 - diethylaminoethanol, 1 - (2<SP>1 </SP>- naphthyl) - 2 - morpholinoethanol, 1 - (1<SP>1</SP> - methoxy - 2<SP>1</SP>- naphthyl) - 2 - aminopropanol, 1 - (5<SP>1</SP> - bromo- 61 - methoxy - 2<SP>1</SP> - naphthyl) - 2 - di - n - butylaminoethanol, 1 - (2<SP>1</SP> - naphthyl) - 2 - (1<SP>1</SP>,2<SP>1</SP>,3<SP>1</SP>,4<SP>1</SP>- tetrahydroisoquinolino) - ethanol and 1 - (2<SP>1</SP>- naphthyl) - 2 - (1<SP>1</SP>,2<SP>1</SP>,3<SP>1</SP>,4<SP>1</SP> - tetrahydro - 21- naphthylamino)-ethanol and pharmaceutically acceptable salts thereof. The compositions may take the form of tablets, pills, capsules, aqueous or oily solutions, aqueous or oily suspensions, emulsions, injectable aqueous or oily solutions or suspensions, and dispersible powders. According to the definition of the active ingredients in the Provisional Specification, when R<SP>1</SP> stands for hydrogen or for a methyl radical, R<SP>2</SP> may be a cycloalkyl radical in the general formula given above.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE627001D BE627001A (en) | 1962-01-15 | ||
GB1354/62A GB974522A (en) | 1962-01-15 | 1962-01-15 | Pharmaceutical compositions for the treatment of coronary artery disease |
FR931449A FR3564M (en) | 1962-01-15 | 1963-04-12 | Medicines with beta-adrenergic blocking activity. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1354/62A GB974522A (en) | 1962-01-15 | 1962-01-15 | Pharmaceutical compositions for the treatment of coronary artery disease |
Publications (1)
Publication Number | Publication Date |
---|---|
GB974522A true GB974522A (en) | 1964-11-04 |
Family
ID=30776082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1354/62A Expired GB974522A (en) | 1962-01-15 | 1962-01-15 | Pharmaceutical compositions for the treatment of coronary artery disease |
Country Status (3)
Country | Link |
---|---|
BE (1) | BE627001A (en) |
FR (1) | FR3564M (en) |
GB (1) | GB974522A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4042624A (en) * | 1975-05-12 | 1977-08-16 | Morton-Norwich Products, Inc. | Antidepressant 2-[(substituted-1-naphthylmethyl)amino]-1-phenylpropanols |
-
0
- BE BE627001D patent/BE627001A/xx unknown
-
1962
- 1962-01-15 GB GB1354/62A patent/GB974522A/en not_active Expired
-
1963
- 1963-04-12 FR FR931449A patent/FR3564M/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR3564M (en) | 1965-09-27 |
BE627001A (en) |
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