GB973922A - Novel thiobarbituric acid derivatives and a process for the manufacture thereof - Google Patents

Novel thiobarbituric acid derivatives and a process for the manufacture thereof

Info

Publication number
GB973922A
GB973922A GB3652662A GB3652662A GB973922A GB 973922 A GB973922 A GB 973922A GB 3652662 A GB3652662 A GB 3652662A GB 3652662 A GB3652662 A GB 3652662A GB 973922 A GB973922 A GB 973922A
Authority
GB
United Kingdom
Prior art keywords
cyano
carbon atoms
alkyl
ester
group containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3652662A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB973922A publication Critical patent/GB973922A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/66—Thiobarbituric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of general formula <FORM:0973922/C1/1> wherein R1 represents an alkyl radical containing 11-18 carbon atoms, and R2 represents an alkyl alkenyl, alkynyl or halo-alkenyl group containing up to 6 carbon atoms or a cyclohexyl or cyclohexenyl group; their alkali metal and alkaline earth metal salts; and their preparation by condensing an ester of formula <FORM:0973922/C1/2> wherein R3 represents a cyano or carbalkoxy radical and R4 represents an alkyl group containing up to 6 carbon atoms, with thiourea and, where R3 is cyano, hydrolysing the resulting 5-substituted-4-imino-2-thio-barbituric acid. Esters II may be prepared by alkylating and/or alkenylating a dialkyl malonate or cyano-acetic acid alkyl ester. Antivirus preparations comprise the Compounds I and salts of the invention with pharmaceutical excipients. Oral and parenteral administration of solid compositions (tablets, dragees, capsules, suppositories) and liquid compositions (solutions, emulsions, suspensions) is mentioned, e.g. for the treatment of influenza. Specifications 797,017 and 825,832 are referred to.
GB3652662A 1961-09-29 1962-09-26 Novel thiobarbituric acid derivatives and a process for the manufacture thereof Expired GB973922A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1135661A CH411901A (en) 1961-09-29 1961-09-29 Process for the preparation of heterocyclic compounds

Publications (1)

Publication Number Publication Date
GB973922A true GB973922A (en) 1964-11-04

Family

ID=4372699

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3652662A Expired GB973922A (en) 1961-09-29 1962-09-26 Novel thiobarbituric acid derivatives and a process for the manufacture thereof

Country Status (5)

Country Link
BE (1) BE622081A (en)
CH (1) CH411901A (en)
ES (1) ES281138A1 (en)
GB (1) GB973922A (en)
MY (1) MY6500153A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3925689A1 (en) * 1989-08-03 1991-02-07 Huels Chemische Werke Ag METHOD FOR PRODUCING NA THIOBARBITURATE
US5869494A (en) * 1995-02-13 1999-02-09 Gulliya; Kirpal S. Uses for barbituric acid analogs
WO1996025402A1 (en) * 1995-02-13 1996-08-22 Gulliya Kirpal S Novel uses for barbituric acid analogs

Also Published As

Publication number Publication date
ES281138A1 (en) 1963-04-01
BE622081A (en) 1963-03-04
CH411901A (en) 1966-04-30
MY6500153A (en) 1965-12-31

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