GB970962A - Ergoline ó derivatives - Google Patents
Ergoline ó derivativesInfo
- Publication number
- GB970962A GB970962A GB44444/62A GB4444462A GB970962A GB 970962 A GB970962 A GB 970962A GB 44444/62 A GB44444/62 A GB 44444/62A GB 4444462 A GB4444462 A GB 4444462A GB 970962 A GB970962 A GB 970962A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- group
- cycloaliphatic
- propionic
- appropriate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention comprises ergoline II derivatives of formula <FORM:0970962/C1/1> wherein R is a hydrogen atom or a methyl group and R1 is an amino-group optionally substituted by an acyl or group derived from an aliphatic, cycloaliphatic or aromatic carboxylic acid having 1 to 10 carbon atoms, or from nicotinic acid, and wherein the hydrogen atoms at the 5- and 10-positions and the 8-R1 group have the b -configuration, and their preparation by converting dihydrolysegic acid II hydrazide or its 1-methyl derivative into the corresponding azide by treatment with sodium nitrite and an inorganic acid, submitting the azide to a Curtius degradation to yield the appropriate 8b -aminoergoline, and, if desired, acylating by means of the acid chloride or anhydride of the appropriate acid. Specified aliphatic, cycloaliphatic and aromatic acyl groups are those derived from acetic, propionic, butyric, valeric, hexanoic, heptanoic, octanoic, decanoic, cyclopentane-carboxylic, b -cyclopentyl-propionic, succinic, benzoic, 2, 6-dimethoxybenzoic, 3, 4, 5-trimethoxybenzoic, b -phenylpropionic, phenoxyacetic, a -phenoxypropionic and ethyl-carbonic acids. The compounds of the invention have oxytocic, antienteraminic, adrenolytic, hypotensive and sedative activity, and may be used in pharmaceutical compositions in combination with a therapeutically acceptable solid or liquid diluent or carrier. Specification 970,963 also is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2138761 | 1961-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB970962A true GB970962A (en) | 1964-09-23 |
Family
ID=11181001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB44444/62A Expired GB970962A (en) | 1961-11-28 | 1962-11-23 | Ergoline ó derivatives |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE625370R (en) |
| CH (1) | CH467782A (en) |
| ES (1) | ES282861A2 (en) |
| GB (1) | GB970962A (en) |
-
1962
- 1962-11-23 GB GB44444/62A patent/GB970962A/en not_active Expired
- 1962-11-26 CH CH1385662A patent/CH467782A/en unknown
- 1962-11-27 ES ES282861A patent/ES282861A2/en not_active Expired
- 1962-11-27 BE BE625370A patent/BE625370R/en active
Also Published As
| Publication number | Publication date |
|---|---|
| CH467782A (en) | 1969-01-31 |
| BE625370R (en) | 1963-03-15 |
| ES282861A2 (en) | 1963-12-01 |
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