GB961628A - New sydnonimines and process for their manufacture - Google Patents
New sydnonimines and process for their manufactureInfo
- Publication number
- GB961628A GB961628A GB2214462A GB2214462A GB961628A GB 961628 A GB961628 A GB 961628A GB 2214462 A GB2214462 A GB 2214462A GB 2214462 A GB2214462 A GB 2214462A GB 961628 A GB961628 A GB 961628A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- para
- aryl
- chlorophenyl
- sydnonimine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises 3-aryl-4-R1-N-R-sydnonimines unsubstituted in the 3-aryl group in which R represents an alkanoyl group containing more than 2 carbon atoms or an alkylcarbamyl group, and R1 represents a hydrogen atom, an alkyl group, a halogen atom or an aryl group which is unsubstituted or is substituted by one or more substituents selected from C1- 6-alkyl, C1- 6-alkoxy, hydroxy, methylenedioxy or tri fluoromethyl groups or halogen atoms; their preparation by reacting a corresponding 3-aryl-sydnonimine with a functional acid derivative of an appropriate carboxylic acid and, if desired, halogenating a resulting compound and/or if desired, converting a free base into a salt or a salt into a free base; and pharmaceutical compositions containing them. The alkanoyl group R may also be substituted e.g. by halogen atoms or by oxo group and may therefore include the a -halopropionyl and acetoacetyl groups. 3-Phenyl -4- (para-chlorophenyl)-sydnonimine is prepared by reacting para-chlorobenzaldehyde with aniline and potassium cyanide to form a -anilino -a - (para-chlorophenyl)-acetonitrile, nitrosating this to yield N-nitroso a -anilino -a - (para-chlorophenyl)-acetonitrile and treating this with methanolic hydrochloric acid. Pharmaceutical compositions comprise the compounds of the invention in admixture or in conjunction with a pharmaceutically suitable carrier. The compositions may be in the form of tablets, dragees, ointments, creams, capsules, solutions, suspensions or emulsions and may contain other therapeutically useful substances. The compounds show analgesic, antipyretic, antiphlogistic and antiallergic properties and are useful as antirheumatics.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH689861 | 1961-06-13 | ||
| CH1107061 | 1961-09-22 | ||
| CH460062 | 1962-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB961628A true GB961628A (en) | 1964-06-24 |
Family
ID=27174906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2214462A Expired GB961628A (en) | 1961-06-13 | 1962-06-07 | New sydnonimines and process for their manufacture |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB961628A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4245100A (en) | 1977-11-28 | 1981-01-13 | Vsesojuzny Nauchno-Issledovatelsky Khimikofarmatsevtichesky Institut Imeni S. Ordzhonikidze | Sydnonimine N-acyl derivatives and method for preparing same |
-
1962
- 1962-06-07 GB GB2214462A patent/GB961628A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4245100A (en) | 1977-11-28 | 1981-01-13 | Vsesojuzny Nauchno-Issledovatelsky Khimikofarmatsevtichesky Institut Imeni S. Ordzhonikidze | Sydnonimine N-acyl derivatives and method for preparing same |
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