ES282861A2 - A procedure for the preparation of derivatives of 6-methyl and 1,6-dimethyl ergoline ii (Machine-translation by Google Translate, not legally binding)
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A procedure for the preparation of derivatives of 6-methyl and 1,6-dimethyl ergoline ii (Machine-translation by Google Translate, not legally binding)
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Pfizer Italia SRL
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Farmaceutici Italia SpA
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Publication of ES282861A2publicationCriticalpatent/ES282861A2/en
C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
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Chemical & Material Sciences
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Organic Chemistry
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Nitrogen Condensed Heterocyclic Rings
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Abstract
Improvements in the subject of the main patent no. 282 859 by "a process for the preparation of 6-methyl- and 1,6-dimethyl-ergoline ii derivatives", of the following structural formula: **figure** Where r is hydrogen or methyl And r "is hydrogen or a radical of an aliphatic, cycloaliphatic, aromatic or heterocyclic acid with 1 to 10 carbon atoms From dihydro-lysergic acid hydrazide ii (or 1-methyl-dihydro-lysergic acid hydrazide ii), which is customarily converted to the corresponding azide, characterized in that said azide is subjected to the demolition of curtius in an acidic medium, preferably hydrochloric acid, to provide 6-methyl- (0-1,6-dimethyl) -8beta-amino-ergoline ii, which is isolated as it is or is transformed into the acyl derivative, in a known manner, by reaction with the anhydride or the chloride of an aliphatic, cycloaliphatic, aromatic or heterocyclic acid with 1 to 10 carbon atoms, in the presence, if desired, of tertiary amines. (Machine-translation by Google Translate, not legally binding)
ES282861A1961-11-281962-11-27A procedure for the preparation of derivatives of 6-methyl and 1,6-dimethyl ergoline ii (Machine-translation by Google Translate, not legally binding)
ExpiredES282861A2
(en)
A procedure for the preparation of new derivatives of 6-methyl and 1,6-dimethyl-ergoline (Machine-translation by Google Translate, not legally binding)
A procedure for preparing new derivatives of 6-methyl and 1,6-dimethyl-8- (alpha-hydroxy-alkyl) -ergoline i (Machine-translation by Google Translate, not legally binding)
A procedure for the preparation of new derivatives of 6-methyl and 1,6-dimethyl-8-amino-methyl-ergoline i (Machine-translation by Google Translate, not legally binding)
A procedure for the preparation of a new class of derivatives of 6-methyl and 1,6-dimethyl-ergoline i (Machine-translation by Google Translate, not legally binding)