GB968714A - Analeptically active n-substituted amino-norcamphane derivatives and their addition salts with acids and their quaternary ammonium compounds - Google Patents

Analeptically active n-substituted amino-norcamphane derivatives and their addition salts with acids and their quaternary ammonium compounds

Info

Publication number
GB968714A
GB968714A GB35384/61A GB3538461A GB968714A GB 968714 A GB968714 A GB 968714A GB 35384/61 A GB35384/61 A GB 35384/61A GB 3538461 A GB3538461 A GB 3538461A GB 968714 A GB968714 A GB 968714A
Authority
GB
United Kingdom
Prior art keywords
compounds
reacting
acids
quaternary ammonium
primary amines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35384/61A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck KGaA
Original Assignee
E Merck AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DEM42332A external-priority patent/DE1110159B/de
Application filed by E Merck AG filed Critical E Merck AG
Publication of GB968714A publication Critical patent/GB968714A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
GB35384/61A 1959-08-01 1961-09-29 Analeptically active n-substituted amino-norcamphane derivatives and their addition salts with acids and their quaternary ammonium compounds Expired GB968714A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEM42332A DE1110159B (de) 1959-08-01 1959-08-01 Verfahren zur Herstellung analeptisch wirksamer N-substituierter Aminonorcamphanderivate bzw. von deren Saeureadditionssalzen und quaternaeren Ammoniumverbindungen
DEM46811A DE1201338B (de) 1959-08-01 1960-10-13 Verfahren zur Herstellung analeptisch wirksamer N-substituierter Aminobicyclo-heptanderivate bzw. von deren Saeureadditions-salzen und quaternaeren Ammonium-verbindungen

Publications (1)

Publication Number Publication Date
GB968714A true GB968714A (en) 1964-09-02

Family

ID=7305711

Family Applications (1)

Application Number Title Priority Date Filing Date
GB35384/61A Expired GB968714A (en) 1959-08-01 1961-09-29 Analeptically active n-substituted amino-norcamphane derivatives and their addition salts with acids and their quaternary ammonium compounds

Country Status (7)

Country Link
US (1) US3164601A (enExample)
BE (1) BE609074R (enExample)
CH (1) CH419105A (enExample)
DE (1) DE1201338B (enExample)
FR (1) FR25F (enExample)
GB (1) GB968714A (enExample)
SE (1) SE310175B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228976A (en) * 1963-06-04 1966-01-11 American Home Prod 1, 4-bis-(aminomethyl)-1-cyclohexene compounds
US3483254A (en) * 1967-01-03 1969-12-09 Merck & Co Inc 2-bornanemethylamines
US3546233A (en) * 1967-05-15 1970-12-08 Upjohn Co Bis- and mono-quaternary salts of 1-(cyclicamino)cyclopropacycloalkanes
US3514486A (en) * 1968-05-23 1970-05-26 Miles Lab 3-isopropylnorbornanamine
DE4019782A1 (de) * 1990-06-21 1992-01-02 Basf Ag 9-amino-2-phenylbicyclo (3.3.1.) und 9-amino-2-phenylbicyclo (3.3.1.) non-2-ene und diese enthaltende therapeutische mittel
US6979698B1 (en) 1997-08-11 2005-12-27 Targacept, Inc. Method of treating cognitive deficits in learning and memory
US6034079A (en) * 1997-08-11 2000-03-07 University Of South Florida Nicotine antagonists for nicotine-responsive neuropsychiatric disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2573644A (en) * 1949-03-22 1951-10-30 Smith Kline French Lab beta-chloroethyl aminoindanes
US2904591A (en) * 1955-02-25 1959-09-15 Ferrosan Ab Alpha-alkyl-propiophenones
DE1039061B (de) * 1955-06-06 1958-09-18 Merck & Co Inc Verfahren zur Herstellung N-substituierter 3-Aminoisocamphanverbindungen, deren Salzen, quaternaeren Ammoniumverbindungen und optisch aktiven Isomeren
US3014037A (en) * 1957-09-12 1961-12-19 Searle & Co N-alkoxyphenalkyl-alpha, alpha-diphenyl-4-piperidinemethanols and processes
US2912459A (en) * 1957-10-24 1959-11-10 Ethicon Inc 2-halo alkanoyl aminobicyclo (2, 2, 1) heptane
US2955073A (en) * 1958-06-02 1960-10-04 Burroughs Wellcome Co Method of treating febrile convulsions
DE1110159B (de) 1959-08-01 1961-07-06 Merck Ag E Verfahren zur Herstellung analeptisch wirksamer N-substituierter Aminonorcamphanderivate bzw. von deren Saeureadditionssalzen und quaternaeren Ammoniumverbindungen
US3074961A (en) * 1960-08-11 1963-01-22 Mcneilab Inc Certain new norbornenes
US2986573A (en) * 1961-01-18 1961-05-30 Schering Corp Method for the treatment of hypertension

Also Published As

Publication number Publication date
CH419105A (de) 1966-08-31
SE310175B (enExample) 1969-04-21
BE609074R (fr) 1962-04-12
FR25F (fr) 1963-03-29
DE1201338B (de) 1965-09-23
US3164601A (en) 1965-01-05

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