GB965063A - Process for the purification of the kallikrien-inactivator and the production of a sparingly water-soluble derivative thereof - Google Patents
Process for the purification of the kallikrien-inactivator and the production of a sparingly water-soluble derivative thereofInfo
- Publication number
- GB965063A GB965063A GB483563A GB483563A GB965063A GB 965063 A GB965063 A GB 965063A GB 483563 A GB483563 A GB 483563A GB 483563 A GB483563 A GB 483563A GB 965063 A GB965063 A GB 965063A
- Authority
- GB
- United Kingdom
- Prior art keywords
- inactivator
- kallikrein
- metaphosphoric acid
- precipitate
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 abstract 5
- 239000002244 precipitate Substances 0.000 abstract 4
- 239000007864 aqueous solution Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000003957 anion exchange resin Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- KNIUHBNRWZGIQQ-UHFFFAOYSA-N 7-diethoxyphosphinothioyloxy-4-methylchromen-2-one Chemical compound CC1=CC(=O)OC2=CC(OP(=S)(OCC)OCC)=CC=C21 KNIUHBNRWZGIQQ-UHFFFAOYSA-N 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 239000000908 ammonium hydroxide Substances 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 239000003729 cation exchange resin Substances 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000005342 ion exchange Methods 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04B—KNITTING
- D04B1/00—Weft knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes
- D04B1/06—Non-run fabrics or articles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Textile Engineering (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF36066A DE1146616B (de) | 1962-02-19 | 1962-02-19 | Verfahren zur Herstellung eines schwerloeslichen Derivates des Kallikrein-Inaktivators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB965063A true GB965063A (en) | 1964-07-29 |
Family
ID=7096298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB483563A Expired GB965063A (en) | 1962-02-19 | 1963-02-06 | Process for the purification of the kallikrien-inactivator and the production of a sparingly water-soluble derivative thereof |
Country Status (8)
| Country | Link |
|---|---|
| BE (2) | BE628551A (en:Method) |
| BR (1) | BR6346884D0 (en:Method) |
| CH (1) | CH430048A (en:Method) |
| DE (1) | DE1146616B (en:Method) |
| FR (1) | FR1348754A (en:Method) |
| GB (1) | GB965063A (en:Method) |
| LU (1) | LU43133A1 (en:Method) |
| NL (1) | NL288750A (en:Method) |
-
0
- BE BE628464D patent/BE628464A/xx unknown
- NL NL288750D patent/NL288750A/xx unknown
- BE BE628551D patent/BE628551A/xx unknown
-
1962
- 1962-02-19 DE DEF36066A patent/DE1146616B/de active Pending
-
1963
- 1963-02-04 LU LU43133D patent/LU43133A1/xx unknown
- 1963-02-05 CH CH136863A patent/CH430048A/de unknown
- 1963-02-06 GB GB483563A patent/GB965063A/en not_active Expired
- 1963-02-08 FR FR924233A patent/FR1348754A/fr not_active Expired
- 1963-02-12 BR BR14688463A patent/BR6346884D0/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL288750A (en:Method) | |
| DE1146616B (de) | 1963-04-04 |
| BE628551A (en:Method) | |
| FR1348754A (fr) | 1964-01-10 |
| BE628464A (en:Method) | |
| CH430048A (de) | 1967-02-15 |
| BR6346884D0 (pt) | 1973-07-19 |
| LU43133A1 (en:Method) | 1963-04-04 |
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