GB961648A - Ergoline derivatives - Google Patents
Ergoline derivativesInfo
- Publication number
- GB961648A GB961648A GB42464/62A GB4246462A GB961648A GB 961648 A GB961648 A GB 961648A GB 42464/62 A GB42464/62 A GB 42464/62A GB 4246462 A GB4246462 A GB 4246462A GB 961648 A GB961648 A GB 961648A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- hydrogen atom
- ergoline
- amide
- methylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention comprises compounds of formula: <FORM:0961648/C1/1> where R is a hydrogen atom or a methyl group and the 8-cyano group and the 10-hydrogen atom do not both have the same configuration, and their preparation by dehydration of the corresponding 8-carbamoyl ergoline, suspended in a tertiary amine, by an aryl sulphonyl halide. The starting material may be prepared by hydrogenation of the corresponding lysergic acid amide in acetic acid in the presence of platinum, followed if desired by methylation with methyl iodide in liquid ammonia in the presence of potassium amide. The compounds of the invention may be reduced to the corresponding amines, for example by lithium aluminium hydride or sodium and ethanol. The compounds of the invention may be used in pharmaceutical compositions in conjunction with a pharmaceutically acceptable diluent or carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2043661 | 1961-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB961648A true GB961648A (en) | 1964-06-24 |
Family
ID=11166901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB42464/62A Expired GB961648A (en) | 1961-11-14 | 1962-11-09 | Ergoline derivatives |
Country Status (2)
Country | Link |
---|---|
BE (1) | BE624729A (en) |
GB (1) | GB961648A (en) |
-
1962
- 1962-11-09 GB GB42464/62A patent/GB961648A/en not_active Expired
- 1962-11-13 BE BE624729A patent/BE624729A/en unknown
Also Published As
Publication number | Publication date |
---|---|
BE624729A (en) | 1963-03-01 |
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