GB958616A - New halogen-containing therapeutic carbamic acid esters and their production - Google Patents
New halogen-containing therapeutic carbamic acid esters and their productionInfo
- Publication number
- GB958616A GB958616A GB6464/62A GB646462A GB958616A GB 958616 A GB958616 A GB 958616A GB 6464/62 A GB6464/62 A GB 6464/62A GB 646462 A GB646462 A GB 646462A GB 958616 A GB958616 A GB 958616A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- trihalohydrin
- nr1r2
- phosgene
- pentaerythritol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
-
- C—CHEMISTRY; METALLURGY
- C05—FERTILISERS; MANUFACTURE THEREOF
- C05F—ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
- C05F17/00—Preparation of fertilisers characterised by biological or biochemical treatment steps, e.g. composting or fermentation
- C05F17/50—Treatments combining two or more different biological or biochemical treatments, e.g. anaerobic and aerobic treatment or vermicomposting and aerobic treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/58—Y being a hetero atom
- C07C275/60—Y being an oxygen atom, e.g. allophanic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/30—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with acyl radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/28—Nitrogen atoms
- C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/141—Feedstock
- Y02P20/145—Feedstock the feedstock being materials of biological origin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W30/00—Technologies for solid waste management
- Y02W30/40—Bio-organic fraction processing; Production of fertilisers from the organic fraction of waste or refuse
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of general formula: <FORM:0958616/C2/1> in which R1 denotes an alkyl, substituted alkyl, cycloalkyl, aryl, aralkyl, amino, substituted amino, carbamyl, substituted carbamyl or heterocyclic radical, R2 denotes a hydrogen atom or an alkyl, substituted alkyl or aryl radical, or in which R1 and R2 together with the amide nitrogen atom may form a heterocyclic ring, and in which X1, X2, X3 are each halogen atoms; and their preparation by introducing the radical -CO-NR1R2 into a pentaerythritol trihalohydrin of general formula: <FORM:0958616/C2/2> to replace the hydroxyl hydrogen thereof by reacting said pentaerythritol trihalohydrin with a carbamic acid halide of general formula: Hal-CO-NR1R2, or with phosgene and then with an amine of general formula HNR1R2, or (when R2=H) with an isocyanate of general formula OCN-R1. Other processes described are reaction of a pentaerythritol trihalohydrin with (1) a urethane R3O.OC-NR1R2, or (2) a haloformic acid ester Ha1-CO.OR3 and then with an amine HNR1R2, or (3) with phosgene and an alcohol R3OH to form a mixed carbonic acid ester and then with an amine HNR1R2. Chloroformic acid-(2, 2, 2-trischloromethyl)-ethyl ester is prepared by reaction of phosgene with the corresponding hydrin. Pharmacological formulations containing compounds of the invention are mentioned for oral, parenteral and rectal administration. The compounds have sedative and hypnotic properties. Specification 780,713 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEB61399A DE1161254B (en) | 1961-02-23 | 1961-02-23 | Process for the production of new, halogen-containing carbamic acid esters |
Publications (1)
Publication Number | Publication Date |
---|---|
GB958616A true GB958616A (en) | 1964-05-21 |
Family
ID=6973188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB6464/62A Expired GB958616A (en) | 1961-02-23 | 1962-02-20 | New halogen-containing therapeutic carbamic acid esters and their production |
Country Status (6)
Country | Link |
---|---|
CH (1) | CH412852A (en) |
DE (1) | DE1161254B (en) |
FR (1) | FR1821M (en) |
GB (1) | GB958616A (en) |
LU (1) | LU41260A1 (en) |
SE (1) | SE305210B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7409781A (en) * | 1973-07-25 | 1975-01-28 | Sandoz Ag | PROCESS FOR FLAAM PROOFING PLASTICS. |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE95375C (en) * | ||||
DE1037443B (en) * | 1954-06-23 | 1958-08-28 | British Schering Res Lab Ltd | Process for the production of narcotic carbamates |
GB850003A (en) * | 1959-04-27 | 1960-09-28 | Sterling Drug Inc | Carbamic acid esters and their preparation |
-
1961
- 1961-02-23 DE DEB61399A patent/DE1161254B/en active Pending
-
1962
- 1962-02-07 CH CH149662A patent/CH412852A/en unknown
- 1962-02-16 LU LU41260D patent/LU41260A1/xx unknown
- 1962-02-20 GB GB6464/62A patent/GB958616A/en not_active Expired
- 1962-02-20 SE SE184262A patent/SE305210B/xx unknown
- 1962-02-23 FR FR888944A patent/FR1821M/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CH412852A (en) | 1966-05-15 |
FR1821M (en) | 1963-05-20 |
SE305210B (en) | 1968-10-21 |
LU41260A1 (en) | 1962-05-10 |
DE1161254B (en) | 1964-01-16 |
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