GB957449A - Fermentative production of bacterial cells containing penicillinamidases - Google Patents

Fermentative production of bacterial cells containing penicillinamidases

Info

Publication number
GB957449A
GB957449A GB2891261A GB2891261A GB957449A GB 957449 A GB957449 A GB 957449A GB 2891261 A GB2891261 A GB 2891261A GB 2891261 A GB2891261 A GB 2891261A GB 957449 A GB957449 A GB 957449A
Authority
GB
United Kingdom
Prior art keywords
penicillinamidases
bacterial cells
cells containing
penicillinamidase
fermentative production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2891261A
Inventor
Peter Anthony Bond
Christopher Towers Calam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB2891261A priority Critical patent/GB957449A/en
Publication of GB957449A publication Critical patent/GB957449A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to a process for the production of bacterial cells comtaining penicillinamidases which comprises the cultivation by conventional methods of a penicillinamidase-producing bacterium in a nutrient medium, which is characterred by the absence of carbohydrate material and by the presence of at least one acetic acid derivative of the formula: R.S.CH2.COOH wherein R stands for a hydrocarbon radical optionally-substituted with one or more halogen atoms, or a salt or ester thereof; whereafter the bacterial cells containing penicillinamidases are recovered. R may be alkyl 1-8C., alkenyl 1-8C. or aryl 1-10C. Preferred salts are the alkali metal, alkaline earth metal ammonium and organic base salts. Preferred esters are those of alkanols of 1-10C. Specified penicillinamidase-producing bacteria are Eschericia Coli, Alcaligenes faecalis and species of the genera Aerobacter, Proteus, Pseudomonas and Micrococcus.
GB2891261A 1961-08-10 1961-08-10 Fermentative production of bacterial cells containing penicillinamidases Expired GB957449A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2891261A GB957449A (en) 1961-08-10 1961-08-10 Fermentative production of bacterial cells containing penicillinamidases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2891261A GB957449A (en) 1961-08-10 1961-08-10 Fermentative production of bacterial cells containing penicillinamidases

Publications (1)

Publication Number Publication Date
GB957449A true GB957449A (en) 1964-05-06

Family

ID=10283196

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2891261A Expired GB957449A (en) 1961-08-10 1961-08-10 Fermentative production of bacterial cells containing penicillinamidases

Country Status (1)

Country Link
GB (1) GB957449A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0638649A2 (en) * 1993-08-05 1995-02-15 Gist-Brocades N.V. New use of alcaligenes faecalis penicillin G acylase

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0638649A2 (en) * 1993-08-05 1995-02-15 Gist-Brocades N.V. New use of alcaligenes faecalis penicillin G acylase
EP0638649A3 (en) * 1993-08-05 1995-03-15 Gist-Brocades N.V. New use of alcaligenes faecalis penicillin G acylase

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