GB1122600A - Method for the production of 3ª‡, 5-cyclo-6ªß, 19-oxido-5ª‡-androstan-17-one - Google Patents

Method for the production of 3ª‡, 5-cyclo-6ªß, 19-oxido-5ª‡-androstan-17-one

Info

Publication number
GB1122600A
GB1122600A GB4893/67A GB489367A GB1122600A GB 1122600 A GB1122600 A GB 1122600A GB 4893/67 A GB4893/67 A GB 4893/67A GB 489367 A GB489367 A GB 489367A GB 1122600 A GB1122600 A GB 1122600A
Authority
GB
United Kingdom
Prior art keywords
androstan
oxido
cyclo
action
aerobic conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4893/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of GB1122600A publication Critical patent/GB1122600A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/83—Arthrobacter
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/843—Corynebacterium

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

3a ,5 - Cyclo - 6b ,19 - oxido - 5a - androstan - 17 - one is obtained by subjecting a compound having the formula <FORM:1122600/C2/1> wherein R is a hydrocarbon side chain of 8 to 10 carbon atoms to the action of a microorganism selected from those micro-organisms of the genera Corynebacterium and Arthrobacter under aerobic conditions or to the action of the enzymes produced by the said micro-organism under aerobic conditions. The yield may be improved by the addition of an inhibitor, e.g. 2,21-bipyridine, pyrogallol, thymol, thiourea, sodium diethyl dithiocarbamate, ethylenediamine tetraacetic acid and disodium and tetrasodium salts thereof, pentachlorophenol, potassium cyanide and sodium azide.
GB4893/67A 1966-02-01 1967-02-01 Method for the production of 3ª‡, 5-cyclo-6ªß, 19-oxido-5ª‡-androstan-17-one Expired GB1122600A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP579966 1966-02-01

Publications (1)

Publication Number Publication Date
GB1122600A true GB1122600A (en) 1968-08-07

Family

ID=11621113

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4893/67A Expired GB1122600A (en) 1966-02-01 1967-02-01 Method for the production of 3ª‡, 5-cyclo-6ªß, 19-oxido-5ª‡-androstan-17-one

Country Status (6)

Country Link
US (1) US3475275A (en)
CH (1) CH478780A (en)
DE (1) DE1618848A1 (en)
FR (1) FR1509708A (en)
GB (1) GB1122600A (en)
NL (1) NL6701506A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814324A (en) * 1987-03-06 1989-03-21 Merck & Co., Inc. Sterol inhibitors of testosterone 5α-reductase
CN100338225C (en) * 2003-01-21 2007-09-19 法马西亚和厄普乔恩公司 A process to produce 19-nor-10beta-carboxylic acids by fungal oxidation of 6-substituted-delta6-pregnanes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1092145A (en) * 1964-06-02 1967-11-22 Noda Inst For Scientific Res Microbiological conversion of steroids
US3398054A (en) * 1965-11-09 1968-08-20 American Home Prod Microbiological transformations of sterols

Also Published As

Publication number Publication date
FR1509708A (en) 1968-01-12
CH478780A (en) 1969-09-30
DE1618848A1 (en) 1971-02-18
US3475275A (en) 1969-10-28
NL6701506A (en) 1967-08-02

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