GB957392A - 16ª‡-hydroxy-steroids - Google Patents

16ª‡-hydroxy-steroids

Info

Publication number
GB957392A
GB957392A GB26865/62A GB2686562A GB957392A GB 957392 A GB957392 A GB 957392A GB 26865/62 A GB26865/62 A GB 26865/62A GB 2686562 A GB2686562 A GB 2686562A GB 957392 A GB957392 A GB 957392A
Authority
GB
United Kingdom
Prior art keywords
steroids
hydroxy
methyl
general formula
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB26865/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of GB957392A publication Critical patent/GB957392A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C12P33/14—Hydroxylating at 16 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises steroids of the general formula: <FORM:0957392/C2/1> wherein R represents hydrogen or methyl and R1 represents the acyl radical of an aliphatic, cycloaliphatic or aromatic acid having from 1 to 9 carbon atoms, and a process for the preparation of 16a -hydroxy-steroids by treating steroid compounds having a methylenic group at the 16-position with a culture produced by growing the microorganisms Nocardia italica or a mutant thereof in a sterilized liquid nutritional medium containing assimilable sources of carbon and nitrogen at from 24 to 30 DEG C. at a pH of from 6 to 7.5. Therapeutic compositions having anticancer activity contain as the active ingredient steroids of the above general formula and a therapeutically acceptable carrier for example, an injectable carrier, or contain as the active ingredient 16a -hydroxy-17a -methyl-19-nor-testosterone and a therapeutically acceptable injectable carrier. Specifications 848,288 and 888,665 are referred to.
GB26865/62A 1961-07-17 1962-07-12 16ª‡-hydroxy-steroids Expired GB957392A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1322761 1961-07-17
IT508862 1962-03-14

Publications (1)

Publication Number Publication Date
GB957392A true GB957392A (en) 1964-05-06

Family

ID=26325638

Family Applications (1)

Application Number Title Priority Date Filing Date
GB26865/62A Expired GB957392A (en) 1961-07-17 1962-07-12 16ª‡-hydroxy-steroids

Country Status (4)

Country Link
DK (1) DK104347C (en)
ES (1) ES279287A1 (en)
FR (1) FR2179M (en)
GB (1) GB957392A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE439586B (en) * 1975-09-05 1985-06-24 Kanebo Ltd SET TO PREPARE A STABLE PHARMACEUTICAL DRY PREPARATION OF AN ALKALIMETAL SALT OF DEHYDROEPIANDROSTERON SULPHATE

Also Published As

Publication number Publication date
ES279287A1 (en) 1963-05-01
FR2179M (en) 1963-12-02
DK104347C (en) 1966-05-09

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