GB952636A - Production of 6.8-dithiooctanamides - Google Patents
Production of 6.8-dithiooctanamidesInfo
- Publication number
- GB952636A GB952636A GB3501960A GB3501960A GB952636A GB 952636 A GB952636 A GB 952636A GB 3501960 A GB3501960 A GB 3501960A GB 3501960 A GB3501960 A GB 3501960A GB 952636 A GB952636 A GB 952636A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dithio
- formula
- octanoyl
- produce
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises (1) compounds of the formula: <FORM:0952636/C2/1> (wherein R and R1 are hydrogen atoms, alkyl radicals of 3 to 5 carbon atoms or aryl radicals, or -NRR1 is the residue of isonicotinic acid hydrazide, or an a -amino-acid or a C1-5-te alkyl ether thereof, with the proviso that when one of R and R1 is hydrogen the other cannot be hydrogen or aryl); and (2) the preparation of compounds of the above general formula wherein R and R1 have the above defined values without the limitation of the proviso and without a lower limit on the number of carbon atoms in the alkyl radicals, by reacting a compound of the formula: <FORM:0952636/C2/2> (wherein X and X1 are halogen atoms) either with sodium disulphide to produce the desired product or with an alkali metal thiosulphate to produce a compound of the formula: <FORM:0952636/C2/3> (wherein M is the alkali metal) and then heating this to produce the desired product, and, if desired, treating the reaction mixture with a caustic alkali to convert undesired by-products to the desired final product. In this process a-amino acid alkyl ester residues are hydrolysed to g -amino acid residues. Examples describe the preparation of 6, 8-dithio-octanamide; N-diisopropyl 6, 8-dithio-octanamide; N-(6, 8-dithio-octanoyl) -L- glutamic acid; N-(6, 8-dithio-octanoyl)-DL-methionine; 6, 8-dithio-octanilide; and 1-isonicotinoyl -2- (6, 8-dithio-octanoyl) - hydrazine hydrochloride. Specification 952,637 is referred to.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3246859 | 1959-10-13 | ||
| JP3246759 | 1959-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB952636A true GB952636A (en) | 1964-03-18 |
Family
ID=26371046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3501960A Expired GB952636A (en) | 1959-10-13 | 1960-10-12 | Production of 6.8-dithiooctanamides |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB952636A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3284466A (en) * | 1963-07-12 | 1966-11-08 | Thiokol Chemical Corp | Preparation of monomeric disulfides |
| US3288797A (en) * | 1963-08-20 | 1966-11-29 | Merck Ag E | Lipoic acid derivatives and their preparation |
-
1960
- 1960-10-12 GB GB3501960A patent/GB952636A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3284466A (en) * | 1963-07-12 | 1966-11-08 | Thiokol Chemical Corp | Preparation of monomeric disulfides |
| US3288797A (en) * | 1963-08-20 | 1966-11-29 | Merck Ag E | Lipoic acid derivatives and their preparation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB952636A (en) | Production of 6.8-dithiooctanamides | |
| GB1019784A (en) | New benzene-sulphonyl-semicarbazides | |
| GB952477A (en) | Improved process for obtaining ª-ª, ª-ª unsaturated carboxylic esters | |
| GB1123929A (en) | Unsaturated sulphonic acid betaines and a process for their production | |
| GB1062386A (en) | Process for preparing pyrazinyl phosphorothioates | |
| GB701150A (en) | 3-substituted-3,4-dihydro-coumarins and process for the manufacture thereof | |
| GB952637A (en) | 6,8-dihalooctanoyl halides and 6,8-dihalooctanamides and the preparation thereof | |
| GB973927A (en) | Thiazolosteroids and production thereof | |
| GB884637A (en) | Cyclopropane derivatives | |
| GB882090A (en) | New sulphamoyl benzamides and processes for the production thereof | |
| ES290324A1 (en) | Procedure for the obtaining of new esteroid phosphoric esters (Machine-translation by Google Translate, not legally binding) | |
| GB990275A (en) | Hardening of proteinaceous materials | |
| GB978665A (en) | Process for the production of new iminodibenzyl derivatives | |
| GB826533A (en) | Naphthoquinone derivatives | |
| GB828987A (en) | New bis-sulphonyl ureas and a process for their production | |
| GB948882A (en) | Process for preparing borazoles | |
| GB833908A (en) | Novel acid hydrazides and a process for the manufacture of same | |
| GB839593A (en) | N-(alpha-hydroxy-beta-trihalogen-ethyl)-pyrrolidones and the process for the production thereof | |
| GB728968A (en) | Process for the preparation of piperazides of the lysergic acid series | |
| GB712728A (en) | Process for the production of new thioethers | |
| GB1014919A (en) | Acetamide derivatives and process for their preparation | |
| GB913593A (en) | Substituted alkyl hydrazines and processes for making them | |
| ES264004A1 (en) | Procedure for the manufacture of benzodiazepin compositions containing fluorine (Machine-translation by Google Translate, not legally binding) | |
| GB718680A (en) | New amides of cycloaliphatic carboxylic acids and a process for their production | |
| GB735899A (en) | Manufacture of hydrazine compounds |