GB950528A - Improvements in or relating to lysergic acid derivatives - Google Patents

Improvements in or relating to lysergic acid derivatives

Info

Publication number
GB950528A
GB950528A GB35478/61A GB3547861A GB950528A GB 950528 A GB950528 A GB 950528A GB 35478/61 A GB35478/61 A GB 35478/61A GB 3547861 A GB3547861 A GB 3547861A GB 950528 A GB950528 A GB 950528A
Authority
GB
United Kingdom
Prior art keywords
acid
radical
lysergic
derivatives
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35478/61A
Inventor
Albert Hofmann
Franz Troxler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz Patent Ltd
Sandoz AG
Original Assignee
Sandoz Patent Ltd
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1142660A external-priority patent/CH392533A/en
Application filed by Sandoz Patent Ltd, Sandoz AG filed Critical Sandoz Patent Ltd
Publication of GB950528A publication Critical patent/GB950528A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises lysergic acid derivatives of general formula: <FORM:0950528/C2/1> in which R1 is a C1-4 alkyl radical, each of R2 and R3 is a hydrogen atom, a C1-4 alkyl or hydroxyalkyl radical or a monocyclic aryl radical, and \sG signifies the radical -CH=C< or <FORM:0950528/C2/2> ; and their acid addition salts; and a process for preparing these compounds in which the corresponding lysergic acid azide is heated to form the isocyanate, which is reacted with an amino compound <FORM:0950528/C2/3> , and, if desired, salification is effected with an organic or inorganic acid. The azides are prepared from the corresponding lysergic and dihydrolysergic acid hydrazides using hydrochloric acid and sodium nitrite solution, and the hydrazides in turn are prepared by heating 1-substituted derivatives of natural ergot alkaloids, or their dihydro derivatives, with anhydrous hydrazine. In the examples the amines used in the preparation of the carbamides are anilene, diethylamine and (+)-butaolamine -(21). Pharmaceutical compositions, having sedative, serotonin inhibiting and/or blood pressure lowering action, comprise the compounds of the invention together with inert carriers. Specification 948,203 is referred to.
GB35478/61A 1960-10-12 1961-10-02 Improvements in or relating to lysergic acid derivatives Expired GB950528A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1142660A CH392533A (en) 1960-10-12 1960-10-12 Process for the production of new urea derivatives
CH263561 1961-03-03

Publications (1)

Publication Number Publication Date
GB950528A true GB950528A (en) 1964-02-26

Family

ID=25690994

Family Applications (1)

Application Number Title Priority Date Filing Date
GB35478/61A Expired GB950528A (en) 1960-10-12 1961-10-02 Improvements in or relating to lysergic acid derivatives

Country Status (1)

Country Link
GB (1) GB950528A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692452A (en) * 1985-06-12 1987-09-08 Spofa, Spojene Podniky Pro Zdravotnickou Vyrobu Method for treatment of endometritis in mammalian females

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692452A (en) * 1985-06-12 1987-09-08 Spofa, Spojene Podniky Pro Zdravotnickou Vyrobu Method for treatment of endometritis in mammalian females

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