ES414894A1 - 3-formylrifamycin azines - Google Patents
3-formylrifamycin azinesInfo
- Publication number
- ES414894A1 ES414894A1 ES414894A ES414894A ES414894A1 ES 414894 A1 ES414894 A1 ES 414894A1 ES 414894 A ES414894 A ES 414894A ES 414894 A ES414894 A ES 414894A ES 414894 A1 ES414894 A1 ES 414894A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- divalent
- formula
- raffle
- aliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BBNQHOMJRFAQBN-UPZFVJMDSA-N 3-formylrifamycin sv Chemical compound OC1=C(C(O)=C2C)C3=C(O)C(C=O)=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O BBNQHOMJRFAQBN-UPZFVJMDSA-N 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- -1 cycloaliphatic Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical class OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 abstract 2
- 229930189077 Rifamycin Natural products 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Substances NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229960003292 rifamycin Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for preparing derivatives of rifamycin, of general formula I, and its 25-dssacetyl and 16,17,18,19,28,29-hexahydro derivatives: Raffle-CH = N-A-N = CH-Raffle (I) in which the symbol Raffle represents the radical rifamycin of formula: ** (See formula) ** and symbol A represents: 1) a direct bond connecting the two nitrogen atoms, 2) a group (see formula) where y is a group -CO-, -CNH-, -CS-, -SO2-, a divalent, aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic radical; R2 and R3 independently represent hydrogen, lower alkyl or taken together can represent a divalent aliphatic chain of 1 to 4 carbon atoms connecting the two terminal nitrogen atoms, 3) a divalent group ** (See formula) ** where X represents a direct bond between the two carbon atoms, a divalent, aliphatic, cycloaliphatic, aromatic or heterocyclic radical; R and R1 can independently be hydrogen, alkyl, cycloalkyl, aryl, heterocyclic or taken together represent an aliphatic chain of 1 to 8 carbon atoms connecting the two terminal carbon atoms; characterized in that it comprises reacting 3-foxmilriphamicin SV and its 25-deacetyl or 16,17,18,19,28,29-hexahydro derivative with a hydrazine compound of formula H2N-A-NH2, where A is defined as above, in an inert organic solvent and at a temperature ranging from room temperature to the boiling point of the solvent. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2507572 | 1972-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES414894A1 true ES414894A1 (en) | 1976-02-01 |
Family
ID=11215624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES414894A Expired ES414894A1 (en) | 1972-05-31 | 1973-05-18 | 3-formylrifamycin azines |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS516679B2 (en) |
| AR (2) | AR198663A1 (en) |
| AT (1) | AT323885B (en) |
| BE (1) | BE800276A (en) |
| CA (1) | CA992961A (en) |
| CH (1) | CH573433A5 (en) |
| DD (1) | DD107285A5 (en) |
| DE (1) | DE2326698A1 (en) |
| ES (1) | ES414894A1 (en) |
| FR (1) | FR2186231B1 (en) |
| GB (1) | GB1392272A (en) |
| HU (1) | HU167317B (en) |
| IE (1) | IE37481B1 (en) |
| IL (1) | IL41926A (en) |
| LU (1) | LU67695A1 (en) |
| NL (1) | NL154510B (en) |
| PL (1) | PL87112B1 (en) |
| RO (1) | RO65182A (en) |
| SE (1) | SE386444B (en) |
| SU (1) | SU514572A3 (en) |
| ZA (1) | ZA732293B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1478563A (en) * | 1975-03-05 | 1977-07-06 | Lepetit Spa | Rifamycin derivatives |
-
1973
- 1973-03-29 GB GB1519173A patent/GB1392272A/en not_active Expired
- 1973-03-30 IE IE508/73A patent/IE37481B1/en unknown
- 1973-04-02 IL IL41926A patent/IL41926A/en unknown
- 1973-04-03 ZA ZA732293A patent/ZA732293B/en unknown
- 1973-05-08 AR AR247892A patent/AR198663A1/en active
- 1973-05-11 CA CA171,060A patent/CA992961A/en not_active Expired
- 1973-05-18 ES ES414894A patent/ES414894A1/en not_active Expired
- 1973-05-25 DE DE2326698A patent/DE2326698A1/en active Pending
- 1973-05-25 NL NL737307319A patent/NL154510B/en not_active IP Right Cessation
- 1973-05-29 FR FR7319518A patent/FR2186231B1/fr not_active Expired
- 1973-05-29 SU SU1920394A patent/SU514572A3/en active
- 1973-05-29 LU LU67695A patent/LU67695A1/xx unknown
- 1973-05-29 DD DD171159A patent/DD107285A5/xx unknown
- 1973-05-29 AT AT468173A patent/AT323885B/en not_active IP Right Cessation
- 1973-05-29 SE SE7307611*A patent/SE386444B/en unknown
- 1973-05-29 JP JP48059434A patent/JPS516679B2/ja not_active Expired
- 1973-05-29 RO RO7374946A patent/RO65182A/en unknown
- 1973-05-30 CH CH783173A patent/CH573433A5/xx not_active IP Right Cessation
- 1973-05-30 PL PL1973162950A patent/PL87112B1/pl unknown
- 1973-05-30 BE BE131720A patent/BE800276A/en unknown
- 1973-05-30 HU HULE706A patent/HU167317B/hu unknown
- 1973-12-19 AR AR251497A patent/AR198715A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| HU167317B (en) | 1975-09-27 |
| CA992961A (en) | 1976-07-13 |
| CH573433A5 (en) | 1976-03-15 |
| IE37481B1 (en) | 1977-08-03 |
| LU67695A1 (en) | 1973-08-02 |
| IL41926A (en) | 1976-04-30 |
| SU514572A3 (en) | 1976-05-15 |
| SE386444B (en) | 1976-08-09 |
| JPS516679B2 (en) | 1976-03-01 |
| JPS4942698A (en) | 1974-04-22 |
| IE37481L (en) | 1973-11-30 |
| ZA732293B (en) | 1974-02-27 |
| PL87112B1 (en) | 1976-06-30 |
| AU5616173A (en) | 1974-11-28 |
| AR198715A1 (en) | 1974-07-15 |
| IL41926A0 (en) | 1973-06-29 |
| FR2186231B1 (en) | 1976-03-05 |
| NL154510B (en) | 1977-09-15 |
| DD107285A5 (en) | 1974-07-20 |
| DE2326698A1 (en) | 1973-12-13 |
| BE800276A (en) | 1973-09-17 |
| FR2186231A1 (en) | 1974-01-11 |
| GB1392272A (en) | 1975-04-30 |
| NL7307319A (en) | 1973-12-04 |
| AT323885B (en) | 1975-08-11 |
| AR198663A1 (en) | 1974-07-15 |
| RO65182A (en) | 1981-05-30 |
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