GB937128A - Method for the preparation of codeinone from thebaine - Google Patents

Method for the preparation of codeinone from thebaine

Info

Publication number
GB937128A
GB937128A GB219562A GB219562A GB937128A GB 937128 A GB937128 A GB 937128A GB 219562 A GB219562 A GB 219562A GB 219562 A GB219562 A GB 219562A GB 937128 A GB937128 A GB 937128A
Authority
GB
United Kingdom
Prior art keywords
codeinone
thebaine
preparation
alkaline
bicarbonates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB219562A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SEMPA-CHIMIE
Original Assignee
SEMPA-CHIMIE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SEMPA-CHIMIE filed Critical SEMPA-CHIMIE
Publication of GB937128A publication Critical patent/GB937128A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Codeinone is prepared by reacting thebaine or a salt thereof with a hydrohalic acid in an anhydrous organic medium and adjusting the pH of the reaction mixture to 8-12 by treatment (preferably in an aqueous medium) with a basic agent selected from alkali and alkaline-earth metal hydroxides, carbonates and bicarbonates, ammonia, salts having an alkaline action, an organic bases.
GB219562A 1961-01-25 1962-01-22 Method for the preparation of codeinone from thebaine Expired GB937128A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR850750A FR1290174A (en) 1961-01-25 1961-01-25 Preparation of codeinone from thebaine

Publications (1)

Publication Number Publication Date
GB937128A true GB937128A (en) 1963-09-18

Family

ID=8747476

Family Applications (1)

Application Number Title Priority Date Filing Date
GB219562A Expired GB937128A (en) 1961-01-25 1962-01-22 Method for the preparation of codeinone from thebaine

Country Status (5)

Country Link
BR (1) BR6235924D0 (en)
CH (1) CH400178A (en)
ES (1) ES273492A1 (en)
FR (1) FR1290174A (en)
GB (1) GB937128A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2362144A1 (en) * 1976-08-17 1978-03-17 Macfarlan Smith Ltd DERIVATIVES OF DIHYDROCODEINONE, THEIR PREPARATION AND THEIR USE IN THE SYNTHESIS OF CODEINE
US5847142A (en) * 1996-08-01 1998-12-08 Johnson Matthey Public Limited Company Preparation of narcotic analgesics

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2362144A1 (en) * 1976-08-17 1978-03-17 Macfarlan Smith Ltd DERIVATIVES OF DIHYDROCODEINONE, THEIR PREPARATION AND THEIR USE IN THE SYNTHESIS OF CODEINE
US5847142A (en) * 1996-08-01 1998-12-08 Johnson Matthey Public Limited Company Preparation of narcotic analgesics

Also Published As

Publication number Publication date
ES273492A1 (en) 1962-03-01
FR1290174A (en) 1962-04-13
BR6235924D0 (en) 1973-05-24
CH400178A (en) 1965-10-15

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