GB935508A - Nucleotide imidazoles - Google Patents

Nucleotide imidazoles

Info

Publication number
GB935508A
GB935508A GB39893/60A GB3989360A GB935508A GB 935508 A GB935508 A GB 935508A GB 39893/60 A GB39893/60 A GB 39893/60A GB 3989360 A GB3989360 A GB 3989360A GB 935508 A GB935508 A GB 935508A
Authority
GB
United Kingdom
Prior art keywords
nucleotide
imidazole
moiety
ribose
phenylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB39893/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB935508A publication Critical patent/GB935508A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

Nucleotide imidazole organic base salts of the formula <FORM:0935508/IV(a)/1> where the BASE is a purine or pyrimidine moiety, the SUGAR is a pentose or a hexose moiety, B is an organic base, R is vinylene, C1-6-alkylvinylene, o-phenylene or mononitro-o-phenylene, and R1 is hydrogen or C1-6-alkyl, are prepared by reacting a nucleotide <FORM:0935508/IV(a)/2> with a 1,11-carbonyl diimidazole <FORM:0935508/IV(a)/3> The sugar moiety may be derived from D-ribose, D-glucose, or 2-deoxy-D-ribose; specified bases B are imidazole, pyridine and trioctylamine. The reaction may be carried out in non-aqueous solvents. Examples relate to adenosine-51-phosphorimidazole, with B as imidazole.
GB39893/60A 1959-12-30 1960-11-21 Nucleotide imidazoles Expired GB935508A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US862788A US2951838A (en) 1959-12-30 1959-12-30 Novel method of preparing nucleotide imidazoles

Publications (1)

Publication Number Publication Date
GB935508A true GB935508A (en) 1963-08-28

Family

ID=25339353

Family Applications (1)

Application Number Title Priority Date Filing Date
GB39893/60A Expired GB935508A (en) 1959-12-30 1960-11-21 Nucleotide imidazoles

Country Status (2)

Country Link
US (1) US2951838A (en)
GB (1) GB935508A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544741A (en) * 1982-03-29 1985-10-01 Robins Roland K Azole dinucleotide compounds and methods for their production

Also Published As

Publication number Publication date
US2951838A (en) 1960-09-06

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