GB921045A - Production of rifamycin b - Google Patents

Production of rifamycin b

Info

Publication number
GB921045A
GB921045A GB24882/59A GB2488259A GB921045A GB 921045 A GB921045 A GB 921045A GB 24882/59 A GB24882/59 A GB 24882/59A GB 2488259 A GB2488259 A GB 2488259A GB 921045 A GB921045 A GB 921045A
Authority
GB
United Kingdom
Prior art keywords
rifamycin
barbituric acid
source
production
phenylethylbarbiturate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24882/59A
Inventor
Pinhas Margalith
Piero Sensi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit SpA filed Critical Lepetit SpA
Priority to GB24882/59A priority Critical patent/GB921045A/en
Priority to CH740360A priority patent/CH398884A/en
Priority to BE592849A priority patent/BE592849A/en
Priority to ES0259611A priority patent/ES259611A1/en
Priority to SE700060A priority patent/SE213190C1/sv
Publication of GB921045A publication Critical patent/GB921045A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C12P17/189—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms containing the rifamycin nucleus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Rifamycin B, which is described in Specification 877,732, is produced by fermenting a rifamycin-producing strain of Streptomyces mediterranei under submerged aerobic conditions in a nutrient medium containing a source of organic nitrogen, an assimilable carbon source, mineral salts and a barbituric acid of the formula: <FORM:0921045/IV(a)/1> wherein R and R1 are hydrogen, lower alkyl, lower alkenyl or a mononuclear carbocyclic aryl radical, and X is oxygen or sulphur, or an alkali metal salt thereof, such as sodium barbiturate, diethylbarbiturate, or phenylethylbarbiturate, or dimethyl, phenylethyl, diethyl or ethylmethyl barbituric acid.
GB24882/59A 1959-07-20 1959-07-20 Production of rifamycin b Expired GB921045A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB24882/59A GB921045A (en) 1959-07-20 1959-07-20 Production of rifamycin b
CH740360A CH398884A (en) 1959-07-20 1960-06-30 Process for the production of rifamycin
BE592849A BE592849A (en) 1959-07-20 1960-07-11 Production of rifomycin.
ES0259611A ES259611A1 (en) 1959-07-20 1960-07-12 Production of rifamycin b
SE700060A SE213190C1 (en) 1959-07-20 1960-07-18

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB24882/59A GB921045A (en) 1959-07-20 1959-07-20 Production of rifamycin b

Publications (1)

Publication Number Publication Date
GB921045A true GB921045A (en) 1963-03-13

Family

ID=10218742

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24882/59A Expired GB921045A (en) 1959-07-20 1959-07-20 Production of rifamycin b

Country Status (5)

Country Link
BE (1) BE592849A (en)
CH (1) CH398884A (en)
ES (1) ES259611A1 (en)
GB (1) GB921045A (en)
SE (1) SE213190C1 (en)

Also Published As

Publication number Publication date
ES259611A1 (en) 1960-11-01
SE213190C1 (en) 1967-05-30
CH398884A (en) 1966-03-15
BE592849A (en) 1960-10-31

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