ES8706327A1 - Mitomycin derivatives - Google Patents

Mitomycin derivatives

Info

Publication number
ES8706327A1
ES8706327A1 ES553549A ES553549A ES8706327A1 ES 8706327 A1 ES8706327 A1 ES 8706327A1 ES 553549 A ES553549 A ES 553549A ES 553549 A ES553549 A ES 553549A ES 8706327 A1 ES8706327 A1 ES 8706327A1
Authority
ES
Spain
Prior art keywords
mitomycin
derivatives
alk2
alk1
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553549A
Other languages
Spanish (es)
Other versions
ES553549A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES553549A0 publication Critical patent/ES553549A0/en
Publication of ES8706327A1 publication Critical patent/ES8706327A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Mitomycin A derivatives II and III which are mitomycin A analogs in which the 7-alkoxy group bears an organic substituent incorporating a disulfide group, are prepared by reacting demethyl mitomycin A or a derivative thereof with an appropriate triazene Ar - N = N - NH - alk2 - S - S - alk1 - R<3> or Ar - N = N - NH - alk2 - S - S - R<4> Mitomycin A is an antibiotic of established utility, and the 7-0-substituted mitosane analogs thereof have similar utility. The mitomycin A derivatives have the formula:- < IMAGE > (Ar, alk1, alk2, R<1>, R<3> and R<4> are various defined groups). The above process may also be used for the production of mitomycin A and derivatives thereof not containing the disulphide group.
ES553549A 1984-09-04 1986-03-31 Mitomycin derivatives Expired ES8706327A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64688884A 1984-09-04 1984-09-04
US74457085A 1985-06-17 1985-06-17

Publications (2)

Publication Number Publication Date
ES553549A0 ES553549A0 (en) 1987-06-16
ES8706327A1 true ES8706327A1 (en) 1987-06-16

Family

ID=27095036

Family Applications (3)

Application Number Title Priority Date Filing Date
ES546687A Expired ES8702408A1 (en) 1984-09-04 1985-09-03 Mitomycin derivatives
ES553548A Expired ES8706326A1 (en) 1984-09-04 1986-03-31 Mitomycin derivatives
ES553549A Expired ES8706327A1 (en) 1984-09-04 1986-03-31 Mitomycin derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES546687A Expired ES8702408A1 (en) 1984-09-04 1985-09-03 Mitomycin derivatives
ES553548A Expired ES8706326A1 (en) 1984-09-04 1986-03-31 Mitomycin derivatives

Country Status (24)

Country Link
JP (1) JPS61112078A (en)
KR (2) KR900008570B1 (en)
AT (1) AT394723B (en)
AU (1) AU581673B2 (en)
BE (1) BE903169A (en)
CA (2) CA1291293C (en)
CH (2) CH667457A5 (en)
CY (2) CY1586A (en)
DE (1) DE3531453C2 (en)
DK (1) DK169478B1 (en)
ES (3) ES8702408A1 (en)
FI (1) FI80700C (en)
FR (1) FR2569696B1 (en)
GB (2) GB2164038B (en)
GR (1) GR852118B (en)
HK (2) HK22491A (en)
HU (1) HU195658B (en)
IE (1) IE58720B1 (en)
IT (1) IT1209660B (en)
LU (1) LU86062A1 (en)
NL (1) NL8502383A (en)
NO (1) NO169441C (en)
PT (1) PT81083B (en)
SE (2) SE465929B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
US4888341A (en) * 1984-09-04 1989-12-19 University Patents, Inc. 6-substituted mitomycin analogs
IL86665A0 (en) * 1987-06-12 1988-11-30 Bristol Myers Co Mitomycin analogs
ZA886812B (en) * 1987-11-23 1989-07-26 Bristol Myers Co Anti-tumor prodrugs
US5023253A (en) * 1987-12-21 1991-06-11 University Patents, Inc. 6-substituted mitomycin analogs
US5075454A (en) * 1990-03-08 1991-12-24 Bristol-Myers Squibb Company 7-(diphenylmethyl)oxy-9a-methoxymitosane
US5175303A (en) * 1990-03-08 1992-12-29 Bristol-Myers Squibb Company Preparation of 7-(diphenylmethyl)oxy-9A-methoxymitosane

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3306821A (en) * 1962-09-04 1967-02-28 Upjohn Co Porfiromycin derivatives and method of making same
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
DE3376114D1 (en) * 1982-12-07 1988-05-05 Kyowa Hakko Kogyo Kk Mitomycin analogues
JPS59175493A (en) * 1983-03-25 1984-10-04 Kyowa Hakko Kogyo Co Ltd Mitomycin derivative and its preparation
KR840008362A (en) * 1983-04-11 1984-12-14 사무엘 제이. 두보프 Amino disulfate
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
US4888341A (en) * 1984-09-04 1989-12-19 University Patents, Inc. 6-substituted mitomycin analogs

Also Published As

Publication number Publication date
JPH0560469B2 (en) 1993-09-02
KR900008570B1 (en) 1990-11-24
PT81083A (en) 1985-10-01
DK401385D0 (en) 1985-09-03
GB8521816D0 (en) 1985-10-09
GR852118B (en) 1986-01-07
DE3531453A1 (en) 1986-03-13
IE852174L (en) 1986-03-04
CA1291293C (en) 1991-10-22
DK401385A (en) 1986-03-05
BE903169A (en) 1986-03-03
IT8522059A0 (en) 1985-09-03
SE8504093L (en) 1986-03-05
AU581673B2 (en) 1989-03-02
SE465929B (en) 1991-11-18
IT1209660B (en) 1989-08-30
ATA258985A (en) 1991-11-15
KR900008840B1 (en) 1990-11-30
JPS61112078A (en) 1986-05-30
FI853338A0 (en) 1985-08-30
GB8726516D0 (en) 1987-12-16
ES553549A0 (en) 1987-06-16
SE9004157D0 (en) 1990-12-27
HU195658B (en) 1988-06-28
GB2196006B (en) 1988-11-09
FR2569696B1 (en) 1991-12-20
GB2164038A (en) 1986-03-12
CY1585A (en) 1992-04-03
SE8504093D0 (en) 1985-09-03
NO169441C (en) 1992-06-24
NL8502383A (en) 1986-04-01
KR860002507A (en) 1986-04-26
CH667094A5 (en) 1988-09-15
LU86062A1 (en) 1986-03-03
GB2196006A (en) 1988-04-20
ES553548A0 (en) 1987-06-16
CA1254892A (en) 1989-05-30
HK22491A (en) 1991-04-04
CY1586A (en) 1992-04-03
SE9004157L (en) 1992-06-28
ES8706326A1 (en) 1987-06-16
FR2569696A1 (en) 1986-03-07
IE58720B1 (en) 1993-11-03
NO169441B (en) 1992-03-16
FI80700C (en) 1990-07-10
HK22391A (en) 1991-04-04
FI853338L (en) 1986-03-05
HUT38942A (en) 1986-07-28
GB2164038B (en) 1988-11-09
AT394723B (en) 1992-06-10
ES546687A0 (en) 1986-12-16
AU4571685A (en) 1986-03-13
DE3531453C2 (en) 1996-07-18
PT81083B (en) 1988-01-22
FI80700B (en) 1990-03-30
DK169478B1 (en) 1994-11-07
ES8702408A1 (en) 1986-12-16
NO853435L (en) 1986-03-05
CH667457A5 (en) 1988-10-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000503