SE9004157L - PROCEDURES FOR PREPARING MITOMYCIN ANALOGS - Google Patents

PROCEDURES FOR PREPARING MITOMYCIN ANALOGS

Info

Publication number
SE9004157L
SE9004157L SE9004157A SE9004157A SE9004157L SE 9004157 L SE9004157 L SE 9004157L SE 9004157 A SE9004157 A SE 9004157A SE 9004157 A SE9004157 A SE 9004157A SE 9004157 L SE9004157 L SE 9004157L
Authority
SE
Sweden
Prior art keywords
mitomycin
alk2
derivatives
analogs
procedures
Prior art date
Application number
SE9004157A
Other languages
Swedish (sv)
Other versions
SE9004157D0 (en
Inventor
D M Vyas
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SE9004157D0 publication Critical patent/SE9004157D0/en
Publication of SE9004157L publication Critical patent/SE9004157L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Mitomycin A derivatives II and III which are mitomycin A analogs in which the 7-alkoxy group bears an organic substituent incorporating a disulfide group, are prepared by reacting demethyl mitomycin A or a derivative thereof with an appropriate triazene Ar - N = N - NH - alk2 - S - S - alk1 - R<3> or Ar - N = N - NH - alk2 - S - S - R<4> Mitomycin A is an antibiotic of established utility, and the 7-0-substituted mitosane analogs thereof have similar utility. The mitomycin A derivatives have the formula:- <IMAGE> (Ar, alk1, alk2, R<1>, R<3> and R<4> are various defined groups). The above process may also be used for the production of mitomycin A and derivatives thereof not containing the disulphide group.
SE9004157A 1984-09-04 1990-12-27 PROCEDURES FOR PREPARING MITOMYCIN ANALOGS SE9004157L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64688884A 1984-09-04 1984-09-04
US74457085A 1985-06-17 1985-06-17

Publications (2)

Publication Number Publication Date
SE9004157D0 SE9004157D0 (en) 1990-12-27
SE9004157L true SE9004157L (en) 1992-06-28

Family

ID=27095036

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8504093A SE465929B (en) 1984-09-04 1985-09-03 SUBSTITUTED 7-OXOMITOSANES
SE9004157A SE9004157L (en) 1984-09-04 1990-12-27 PROCEDURES FOR PREPARING MITOMYCIN ANALOGS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE8504093A SE465929B (en) 1984-09-04 1985-09-03 SUBSTITUTED 7-OXOMITOSANES

Country Status (24)

Country Link
JP (1) JPS61112078A (en)
KR (2) KR900008570B1 (en)
AT (1) AT394723B (en)
AU (1) AU581673B2 (en)
BE (1) BE903169A (en)
CA (2) CA1291293C (en)
CH (2) CH667457A5 (en)
CY (2) CY1585A (en)
DE (1) DE3531453C2 (en)
DK (1) DK169478B1 (en)
ES (3) ES8702408A1 (en)
FI (1) FI80700C (en)
FR (1) FR2569696B1 (en)
GB (2) GB2164038B (en)
GR (1) GR852118B (en)
HK (2) HK22391A (en)
HU (1) HU195658B (en)
IE (1) IE58720B1 (en)
IT (1) IT1209660B (en)
LU (1) LU86062A1 (en)
NL (1) NL8502383A (en)
NO (1) NO169441C (en)
PT (1) PT81083B (en)
SE (2) SE465929B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
US4888341A (en) * 1984-09-04 1989-12-19 University Patents, Inc. 6-substituted mitomycin analogs
IL86665A0 (en) * 1987-06-12 1988-11-30 Bristol Myers Co Mitomycin analogs
ZA886812B (en) * 1987-11-23 1989-07-26 Bristol Myers Co Anti-tumor prodrugs
US5023253A (en) * 1987-12-21 1991-06-11 University Patents, Inc. 6-substituted mitomycin analogs
US5175303A (en) * 1990-03-08 1992-12-29 Bristol-Myers Squibb Company Preparation of 7-(diphenylmethyl)oxy-9A-methoxymitosane
US5075454A (en) * 1990-03-08 1991-12-24 Bristol-Myers Squibb Company 7-(diphenylmethyl)oxy-9a-methoxymitosane

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3306821A (en) * 1962-09-04 1967-02-28 Upjohn Co Porfiromycin derivatives and method of making same
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
DE3376114D1 (en) * 1982-12-07 1988-05-05 Kyowa Hakko Kogyo Kk Mitomycin analogues
JPS59175493A (en) * 1983-03-25 1984-10-04 Kyowa Hakko Kogyo Co Ltd Mitomycin derivative and its preparation
KR840008362A (en) * 1983-04-11 1984-12-14 사무엘 제이. 두보프 Amino disulfate
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
US4888341A (en) * 1984-09-04 1989-12-19 University Patents, Inc. 6-substituted mitomycin analogs

Also Published As

Publication number Publication date
ES553548A0 (en) 1987-06-16
HK22491A (en) 1991-04-04
GB2164038A (en) 1986-03-12
KR900008840B1 (en) 1990-11-30
CY1585A (en) 1992-04-03
IE852174L (en) 1986-03-04
DK401385A (en) 1986-03-05
GB8726516D0 (en) 1987-12-16
FI80700B (en) 1990-03-30
AU581673B2 (en) 1989-03-02
CY1586A (en) 1992-04-03
GB2196006B (en) 1988-11-09
JPS61112078A (en) 1986-05-30
SE465929B (en) 1991-11-18
JPH0560469B2 (en) 1993-09-02
ES546687A0 (en) 1986-12-16
FI853338A0 (en) 1985-08-30
AU4571685A (en) 1986-03-13
GB8521816D0 (en) 1985-10-09
PT81083A (en) 1985-10-01
ES8702408A1 (en) 1986-12-16
FI853338L (en) 1986-03-05
HUT38942A (en) 1986-07-28
NL8502383A (en) 1986-04-01
NO169441C (en) 1992-06-24
DE3531453A1 (en) 1986-03-13
FR2569696B1 (en) 1991-12-20
DK169478B1 (en) 1994-11-07
CH667094A5 (en) 1988-09-15
GB2196006A (en) 1988-04-20
AT394723B (en) 1992-06-10
CA1254892A (en) 1989-05-30
ES8706326A1 (en) 1987-06-16
IT8522059A0 (en) 1985-09-03
NO169441B (en) 1992-03-16
KR860002507A (en) 1986-04-26
SE9004157D0 (en) 1990-12-27
FI80700C (en) 1990-07-10
SE8504093D0 (en) 1985-09-03
DK401385D0 (en) 1985-09-03
CA1291293C (en) 1991-10-22
PT81083B (en) 1988-01-22
NO853435L (en) 1986-03-05
IT1209660B (en) 1989-08-30
HK22391A (en) 1991-04-04
HU195658B (en) 1988-06-28
DE3531453C2 (en) 1996-07-18
GB2164038B (en) 1988-11-09
GR852118B (en) 1986-01-07
FR2569696A1 (en) 1986-03-07
ES553549A0 (en) 1987-06-16
IE58720B1 (en) 1993-11-03
KR900008570B1 (en) 1990-11-24
ATA258985A (en) 1991-11-15
CH667457A5 (en) 1988-10-14
SE8504093L (en) 1986-03-05
ES8706327A1 (en) 1987-06-16
BE903169A (en) 1986-03-03
LU86062A1 (en) 1986-03-03

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