GB923052A - Method for the preparation of substances possessing tumour-inhibiting effects - Google Patents

Method for the preparation of substances possessing tumour-inhibiting effects

Info

Publication number
GB923052A
GB923052A GB3687461A GB3687461A GB923052A GB 923052 A GB923052 A GB 923052A GB 3687461 A GB3687461 A GB 3687461A GB 3687461 A GB3687461 A GB 3687461A GB 923052 A GB923052 A GB 923052A
Authority
GB
United Kingdom
Prior art keywords
bis
ethylene
methyl
acid
benzoquinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3687461A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyesult Gyogyszer es Tapszergyar
Original Assignee
Egyesult Gyogyszer es Tapszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyesult Gyogyszer es Tapszergyar filed Critical Egyesult Gyogyszer es Tapszergyar
Publication of GB923052A publication Critical patent/GB923052A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Compounds having a specific tumour-inhibiting effect comprise salts of heparinic acid with basic compounds possessing cytostatic or anti-metabolic properties. The heparinic acid is in the free-acid form, and need have no anticoagulant properties. The basic components of the salts have cytostatic properties or inhibit the growth of enzymes in tumour metabolism. Specified classes of compounds are: nitrogen mustards and semi-mustards, e.g. 1,6-bis-(b -chloroethylamino)-1,6-deoxy-D-mannitol and 2-[bis-(b -chloroethyl)-aminomethyl]-benzimidazole; quinone-nitrogen mustards and quinone-ethylene-imino derivatives, e.g. 2,5-bis-b -chloro-ethylamino-benzoquinone-(1,4), 2,5-bis-chloroethylaminobenzoquinone-(1,4), 2,5-bis-ethylene-imino-benzoquinone-(1,4), 2,5-bis-n-propoxy-3,6-ethylene-iminobenzoquinone-(1,4), 2,5-bis-ethylene-imino-hydroquinone, 2,5-bis-b -dimethyl aminoethoxy-3,6-bis-ethylene-iminobenzoquinone-(1,4), 2,5-dichloro-3,6-bis-b -N-piperidino-ethylamino-benzoquinone-(1,4) 2,5-di-N1-methyl-N-piperazino-benzoquinone-(1,4); sulphonamides, e.g. sulphonilamide, sulphaguanidine, 2-sulpha-4-methyl-thiazole, and 2-sulpha-4,6 6-dimethyl-pyrimidine; quinine and synthetic anti-malarials such as 3-chloro-7-methoxy-9-(d -diethylamino-a -methyl-n-butylamino) -acridine, 6-methoxy-8-(d -diethylamino-a -methyl-n-butylamino)-quinoline and 7-chloro-4-(d -diethylamino-a -methyl-n-butylamino)-quinoline; arsenic compounds, e.g. p-amino-phenyldichloroarsine, 3-amino-4-hydroxyarsonic acid and 3-amino-4-hydroxyphenyl-dichloroarsine; and D(-)-threo-1-p-nitrophenyl-2-amino-1,3-propanediol. Salts are made by mixing heparinic acid and a basic compound in organic or inorganic solvents, preferably water or a lower alcohol, preferably at -10 DEG to +30 DEG C. The resulting salt may be precipitated with, e.g. ethanol. The proportion of base to acid may be such as to neutralize all -SO3H groups or to leave some free. Preferably an aqueous solution of the salt has pH 1,5 to 7. Examples detail the preparation of salts, with their effect on animal tumours.
GB3687461A 1960-10-19 1961-10-13 Method for the preparation of substances possessing tumour-inhibiting effects Expired GB923052A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUEE000807 1960-10-19

Publications (1)

Publication Number Publication Date
GB923052A true GB923052A (en) 1963-04-10

Family

ID=10995144

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3687461A Expired GB923052A (en) 1960-10-19 1961-10-13 Method for the preparation of substances possessing tumour-inhibiting effects

Country Status (6)

Country Link
BE (1) BE609334A (en)
BR (1) BR6133547D0 (en)
CH (1) CH414583A (en)
DK (1) DK115214B (en)
GB (1) GB923052A (en)
SE (1) SE304504B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985005362A1 (en) * 1984-05-21 1985-12-05 Bodor Nicholas S Orally active heparin multiplets

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985005362A1 (en) * 1984-05-21 1985-12-05 Bodor Nicholas S Orally active heparin multiplets

Also Published As

Publication number Publication date
BR6133547D0 (en) 1973-05-31
CH414583A (en) 1966-06-15
SE304504B (en) 1968-09-30
BE609334A (en) 1962-02-15
DK115214B (en) 1969-09-15

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