GB533480A - Process for the manufacture of salts of cinchona alkaloids with ascorbic acid - Google Patents

Process for the manufacture of salts of cinchona alkaloids with ascorbic acid

Info

Publication number
GB533480A
GB533480A GB29803/39A GB2980339A GB533480A GB 533480 A GB533480 A GB 533480A GB 29803/39 A GB29803/39 A GB 29803/39A GB 2980339 A GB2980339 A GB 2980339A GB 533480 A GB533480 A GB 533480A
Authority
GB
United Kingdom
Prior art keywords
ascorbates
ascorbic acid
alkaloids
hydroquinine
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29803/39A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB533480A publication Critical patent/GB533480A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Steroid Compounds (AREA)

Abstract

533,480. Alkaloid ascorbates. HOFFMANN-LA ROCHE & CO. AKT.-GES., F. Nov. 10, 1939, No. 29803. Convention date, Dec. 1, 1938. [Class 2 (iii)] Ascorbates of cinchona alkaloids are made by heating the alkaloids with esters of 2- ketogalonic acid in organic solvents. In examples the ascorbates of quinine, hydroquinine and quinidene are prepared from the methyl and ethyl esters. Isohexyl, propyl and ethyl alcohols are used as the solvents but amyl alcohol is also suitable. The products are crystallized by cooling or precipitated by ether. Hydroquinine ascorbate is freely soluble in water ; the solution may be stabilized against hydrolysis by adding a little free ascorbic acid. The aqueous solutions of the products may be used for injection.
GB29803/39A 1938-12-01 1939-11-10 Process for the manufacture of salts of cinchona alkaloids with ascorbic acid Expired GB533480A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH533480X 1938-12-01

Publications (1)

Publication Number Publication Date
GB533480A true GB533480A (en) 1941-02-13

Family

ID=4518614

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29803/39A Expired GB533480A (en) 1938-12-01 1939-11-10 Process for the manufacture of salts of cinchona alkaloids with ascorbic acid

Country Status (1)

Country Link
GB (1) GB533480A (en)

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