GB918736A - Process for the microbiological oxidation of steroids - Google Patents
Process for the microbiological oxidation of steroidsInfo
- Publication number
- GB918736A GB918736A GB1935159A GB1935159A GB918736A GB 918736 A GB918736 A GB 918736A GB 1935159 A GB1935159 A GB 1935159A GB 1935159 A GB1935159 A GB 1935159A GB 918736 A GB918736 A GB 918736A
- Authority
- GB
- United Kingdom
- Prior art keywords
- liquid
- steroids
- mycelium
- microorganisms
- aqueous liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
- C12P33/08—Hydroxylating at 11 position
- C12P33/10—Hydroxylating at 11 position at 11 alpha-position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Oxidised steroids are prepared by the action of mycelium forming microorganisms with oxidisable steroids in which an aqueous liquid containing oxygen and the steroid to be oxidised are pushed through a stationary mass of the mycelium. It is preferable to use a static layer of the microorganisms in pellet rather than fibrous form, and the aqueous liquid may be the culture medium for the microorganisms. It is possible to use a continuous circulation process in which a part of the aqueous liquid is separated from the mycelium while circulation is continued, the volume of liquid separated being replaced by further liquid, e.g. fresh nutrient culture medium, pure water or physiological saline, and the further liquid may contain additional oxidisable steroid, e.g. of the pregnane series which may be unsubstituted in the 11-position. The process is particularly suitable for the introduction of an oxygen function at the 11-position such as an 11a -hydroxy group by means of Rhizopur nigricans or an 11b -hydroxy group by means of Cunninghametta blakesleeana. The introduction of oxygen into the system may be used to circulate the liquid. In the examples 11a -hydroxy-progesterone and hydrocortisone are prepared from the corresponding 11-desoxy compounds.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUGO000627 | 1958-06-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB918736A true GB918736A (en) | 1963-02-20 |
Family
ID=10996621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1935159A Expired GB918736A (en) | 1958-06-05 | 1959-06-05 | Process for the microbiological oxidation of steroids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB918736A (en) |
-
1959
- 1959-06-05 GB GB1935159A patent/GB918736A/en not_active Expired
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