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Expired
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GB405261A
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Bayer AG
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Bayer AG
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Publication of GB903809ApublicationCriticalpatent/GB903809A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
The invention comprises amines of the general formula: (CH3)2CH-C(CH3)2NRR1 and their acid addition salts wherein R and R1 denote straight or branched alkyl radicals containing 1-4 carbon atoms, the total number of carbon atoms in R and R1 not exceeding 5, and the preparation thereof by reacting a 2,3-dimethylbutyl-2-amine or an N-(C1-C4)-alkyl-2,3-dimethylbutyl-2-amine with a reactive ester of a C1-C4 alkanol, optionally in the presence of an acid-binding agent or with an appropriate aliphatic aldehyde or ketone and formic acid or an alkyl formate (according to the Leuckart reaction) or reducing an appropriate aliphatic aldehyde or ketone in the presence of the above amines. 2,3-Dimethylbutyl-2-amine is prepared from 2,3-dimethylbutane-2-ol and sodium cyanide in glacial acetic/sulphuric acid and hydrolysing the N-formyl-2,3-dimethylbutyl-2-amine. N-Isopropyl-2,3-dimethylbutyl - 2 - -amine is prepared from the primary amine and isopropyl bromide.
A procedure for the preparation of derivatives of esters and amidas of the amino-benzoic acid (Machine-translation by Google Translate, not legally binding)