GB898781A - Triiodinated diamino-propionic acid derivatives and their use in x-ray contrast media - Google Patents
Triiodinated diamino-propionic acid derivatives and their use in x-ray contrast mediaInfo
- Publication number
- GB898781A GB898781A GB36066/58A GB3606658A GB898781A GB 898781 A GB898781 A GB 898781A GB 36066/58 A GB36066/58 A GB 36066/58A GB 3606658 A GB3606658 A GB 3606658A GB 898781 A GB898781 A GB 898781A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- propionic acid
- aliphatic
- ester
- contrast media
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940039231 contrast media Drugs 0.000 title abstract 3
- 239000002872 contrast media Substances 0.000 title abstract 3
- YSFQIJDACSFIOH-UHFFFAOYSA-N 2,2-diaminopropanoic acid Chemical class CC(N)(N)C(O)=O YSFQIJDACSFIOH-UHFFFAOYSA-N 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 3
- 229920002261 Corn starch Polymers 0.000 abstract 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
- 235000019759 Maize starch Nutrition 0.000 abstract 2
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical class CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001298 alcohols Chemical class 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 150000007529 inorganic bases Chemical class 0.000 abstract 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000002156 mixing Methods 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 150000007530 organic bases Chemical class 0.000 abstract 2
- 235000019260 propionic acid Nutrition 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- HCMJKKDNASHJIT-UHFFFAOYSA-N 2-(3,5-diaminophenyl)-3,3,3-triiodopropanoic acid Chemical class IC(C(C(=O)O)C1=CC(=CC(=C1)N)N)(I)I HCMJKKDNASHJIT-UHFFFAOYSA-N 0.000 abstract 1
- 244000060011 Cocos nucifera Species 0.000 abstract 1
- 235000013162 Cocos nucifera Nutrition 0.000 abstract 1
- 239000001828 Gelatine Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- QZRGKCOWNLSUDK-UHFFFAOYSA-N Iodochlorine Chemical compound ICl QZRGKCOWNLSUDK-UHFFFAOYSA-N 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 abstract 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
- JNFLSZPZYOMFNP-UHFFFAOYSA-M [K+].[I-].Cl.Cl Chemical compound [K+].[I-].Cl.Cl JNFLSZPZYOMFNP-UHFFFAOYSA-M 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000012876 carrier material Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000026045 iodination Effects 0.000 abstract 1
- 238000006192 iodination reaction Methods 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- 235000009973 maize Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 abstract 1
- 235000020374 simple syrup Nutrition 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 239000008347 soybean phospholipid Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000004018 waxing Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0495—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound intended for oral administration
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DESCH23286A DE1125589B (de) | 1957-12-18 | 1957-12-18 | Roentgenkontrastmittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB898781A true GB898781A (en) | 1962-06-14 |
Family
ID=7429561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB36066/58A Expired GB898781A (en) | 1957-12-18 | 1958-11-10 | Triiodinated diamino-propionic acid derivatives and their use in x-ray contrast media |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3047466A (enExample) |
| BE (1) | BE573412A (enExample) |
| DE (1) | DE1125589B (enExample) |
| FR (1) | FR1280566A (enExample) |
| GB (1) | GB898781A (enExample) |
| NL (2) | NL105700C (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3419657A (en) * | 1964-06-23 | 1968-12-31 | Dagra Nv | Iodopanoic acid in a hydrogel |
| US3542861A (en) * | 1967-05-08 | 1970-11-24 | Sterling Drug Inc | 3-amino-5-cycloalkylcarbonylamino-2,4,6-triiodobenzoic acids |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US705726A (en) * | 1902-05-05 | 1902-07-29 | James C Wallace | Filter-bed. |
| US2705726A (en) * | 1949-07-23 | 1955-04-05 | Sterling Drug Inc | Iodinated aminophenyl-carboxylic acids |
| DE970133C (de) * | 1953-02-06 | 1958-08-21 | Schering Ag | Verfahren zur Herstellung von N-Acylderivaten der 3, 5-Diamino-2, 4, 6-trijod-benzoesaeure |
| GB782313A (en) * | 1954-07-26 | 1957-09-04 | Mallinckrodt Chemical Works | Manufacture of new 2:4:6-triiodobenzoic acid compounds |
| US2820814A (en) * | 1955-03-21 | 1958-01-21 | Schering Corp | Polyiodinated 5-aminoisophthalic acids, salts, and esters |
| US2921884A (en) * | 1957-09-30 | 1960-01-19 | Sterling Drug Inc | Pharmaceutical compositions |
-
1957
- 1957-12-18 DE DESCH23286A patent/DE1125589B/de active Pending
-
1958
- 1958-11-10 GB GB36066/58A patent/GB898781A/en not_active Expired
- 1958-11-28 BE BE573412A patent/BE573412A/fr unknown
- 1958-12-09 US US779065A patent/US3047466A/en not_active Expired - Lifetime
- 1958-12-16 NL NL234265A patent/NL105700C/xx active
- 1958-12-16 NL NL234265D patent/NL234265A/xx unknown
- 1958-12-18 FR FR782026A patent/FR1280566A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL234265A (enExample) | 1963-03-15 |
| NL105700C (enExample) | 1963-08-15 |
| BE573412A (fr) | 1959-03-16 |
| DE1125589B (de) | 1962-03-15 |
| US3047466A (en) | 1962-07-31 |
| FR1280566A (fr) | 1962-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US2831854A (en) | Method for preparing fatty esters of non-reducing oligosaccharides in the presence of an amide | |
| US4564475A (en) | Compositions containing unsaturated fatty acid compounds and method of stabilizing unsaturated fatty acid compounds | |
| DE3268321D1 (en) | Carboxylic-acid derivatives, process for their preparation and medicines containing them | |
| DE2414680C2 (de) | Substituierte 2-Furancarbonsäuren und 2-Furancarbonsäureester, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen enthalten | |
| GB1604162A (en) | Compositions containing prostaglandin analogues | |
| Iyengar et al. | Melting points of synthetic wax esters | |
| US3825591A (en) | Orally applicable contrast agents for cholecystography | |
| GB898781A (en) | Triiodinated diamino-propionic acid derivatives and their use in x-ray contrast media | |
| DE3787844T2 (de) | Thioester und dessen Verwendung zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Ischämie und von Reperfusion-Syndromen. | |
| US3444187A (en) | Novel beta-haloglutamate and alpha,beta-dehydroglutamate compounds | |
| JPS60204739A (ja) | エイコサポリエン酸系化合物含有粉体 | |
| US3484481A (en) | 3-amino-2,4,6-triiodobenzoic acid derivatives | |
| DE2407016C3 (de) | 2-Alkoxybenzoylaminocarbonsäuren, Verfahren zu deren Herstellung und diese Verbindungen enthaltende antipyretische Mittel | |
| DE69809743T2 (de) | An omega-3 ungesättigten fettsäuren angereicherte wachsester, ihre herstellung und verwendung | |
| JP2831395B2 (ja) | アスコルビン酸エステル | |
| Strong et al. | The Chemistry of Mold Tissue. IV. The Lipids of Aspergillus Sydowi1, 2 | |
| GB785670A (en) | Improvements in or relating to chemical compounds for use as x-ray diagnostic agentsand to processes for their preparation | |
| US2103522A (en) | Therapeutic composition | |
| GB1116586A (en) | Iodinated derivatives of amino-isobutyric acid and rontgen contrast compositions containing them | |
| US3072689A (en) | Process for preparation of iodized lecithin | |
| US3755417A (en) | Tris (4-chlorophenoxy)acetic acid and esters thereof | |
| GB1077669A (en) | Sulphoxide syntheses | |
| DE2033997A1 (de) | Neue alpha (p Chlorophenoxy)Isobutter säurederivate | |
| US3792055A (en) | Heterocyclic amides | |
| DE1493513B2 (de) | 21.01.63 Schweiz 663-63 Sulfamylanthranilsäuren, deren therapeutisch verwendbare Salze, Verfahren zu ihrer Herstellung und diese enthaltenden pharmazeutischen Präparate CIBA-GEIGY AG, Basel (Schweiz) |