GB893318A - Stable blood detecting composition - Google Patents

Stable blood detecting composition

Info

Publication number
GB893318A
GB893318A GB36615/60A GB3661560A GB893318A GB 893318 A GB893318 A GB 893318A GB 36615/60 A GB36615/60 A GB 36615/60A GB 3661560 A GB3661560 A GB 3661560A GB 893318 A GB893318 A GB 893318A
Authority
GB
United Kingdom
Prior art keywords
hydroperoxide
organic
phenylenediamine
cresol
colour
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB36615/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of GB893318A publication Critical patent/GB893318A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/726—Devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/725—Haemoglobin using peroxidative activity
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/904—Oxidation - reduction indicators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A test composition in dry solid form for the detection of peroxidase activity due to occult blood in body fluids comprises an organic hydroperoxide and an indicator material which changes colour in the presence of said organic hydroperoxide and blood. The organic hydroperoxide and the indicator material may be impregnated into a bibulous carrier, for example, a filter-paper strip, or may be in the form of tablets. The organic hydroperoxide is preferably first encapsulated within microspherical bubbles of a colloidal substance such as polyvinyl alcohol, gelatin, gum arabic, or carboxy vinyl polymer. Specified organic hydroperoxides are ethyl hydroperoxide, 1-cyclohexyl hydroperoxide-1, cumene hydroperoxide, diisopropyl benzene hydroperoxide, para-menthane hydroperoxide, 2,5-dimethyl hexane-2.5-dihydroperoxide, and titanium potassium oxalate hydroperoxide. Specified indicators are aniline, o-tolidine, o-toluidine, p-toluidine, o-phenylenediamine, N, N1-dimethylp-phenylenediamine, N, N1-diethyl-p-phenylenediamine, benzidine, di-anisidine, o-cresol, m-cresol, p-cresol, a - and b -naphthols, catechol, guaicol, and pyrogallol. The composition is preferably buffered to a pH of 4 to 7, e.g. with citrates, tartrates, phosphates, phthalates, or acetates. In the case of acetates, the buffer may comprise calcium, sodium, potassium, or lithium acetate and an acid, such as citric, fumaric, itaconic, maleic, malic, malonic, or mandelic acid, which on hydrolysis will react with the acetate to form acetic acid. The compositions may also contain stabilizers such as gelatin, algin, carogein, casein, or albumin. Test tablets may comprise excipients, such as lactose, starch, or flour, to facilitate the formation of granules. A background dye may be included so that its colour contrasts strongly with the indicator colour. Examples of such dyes are D and C Red No. 35, D and C Yellow No. 11, and D and C Orange No. 15. Specification 772,374 and U.S.A. Specifications 2,800,457 and 2,838,377 are referred to.
GB36615/60A 1959-11-02 1960-10-25 Stable blood detecting composition Expired GB893318A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US850116A US3012976A (en) 1959-11-02 1959-11-02 Specific test composition for occult blood

Publications (1)

Publication Number Publication Date
GB893318A true GB893318A (en) 1962-04-04

Family

ID=25307297

Family Applications (1)

Application Number Title Priority Date Filing Date
GB36615/60A Expired GB893318A (en) 1959-11-02 1960-10-25 Stable blood detecting composition

Country Status (2)

Country Link
US (1) US3012976A (en)
GB (1) GB893318A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0222700A1 (en) * 1985-10-31 1987-05-20 Warner-Lambert Company Composition and method for determining peroxidase-like activity of hemoglobin
WO1992022669A1 (en) * 1991-06-19 1992-12-23 Hypoguard (Uk) Limited Reagent mixtures for glucose assay
WO2010079329A1 (en) 2009-01-08 2010-07-15 James Gordon Campbell Method and apparatus for alcohol concentration detection in a blood sample

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL126365C (en) * 1963-06-24
US4132527A (en) * 1974-01-09 1979-01-02 Shionogi & Co., Ltd. Diagnostic compositions, diagnosing instruments, and methods of manufacturing same
US3966414A (en) * 1974-01-16 1976-06-29 Bio-Medical Sciences, Inc. Time temperature indicators
US4071318A (en) * 1977-03-14 1978-01-31 Miles Laboratories, Inc. Test composition and device for determining peroxidatively active substances
US4071321A (en) * 1977-03-14 1978-01-31 Miles Laboratories, Inc. Test composition and device for determining peroxidatively active substances
US4071317A (en) * 1977-03-14 1978-01-31 Miles Laboratories, Inc. Test composition and device for determining peroxidatively active substances and process for preparing same
US4175923A (en) * 1978-06-26 1979-11-27 Friend William G Method and apparatus for occult blood testing in the home
US4148611A (en) * 1978-06-28 1979-04-10 Miles Laboratories, Inc. Test composition, device and method for the detection of peroxidatively active substances
US4278439A (en) * 1979-12-17 1981-07-14 Miles Laboratories, Inc. Sensitizers for peroxidative activity tests
US4526869A (en) * 1980-09-24 1985-07-02 Regents Of The University Of Minnesota Method for quantitatively determining the concentration of hemoglobin in a biological sample
US4340669A (en) * 1981-02-12 1982-07-20 Miles Laboratories, Inc. System for the determination of glucose in fluids
US4956300A (en) * 1982-01-05 1990-09-11 Helena Laboratories Corporation Aid for determining the presence of occult blood, method of making the aid, and method of using the aid
US4473079A (en) * 1982-09-13 1984-09-25 Jasper David A Simple, small, self-contained tests for occult blood
US4511533A (en) * 1982-10-07 1985-04-16 Helena Laboratories Corporation Test kit for performing a medical test
US4582685A (en) * 1982-10-07 1986-04-15 Helena Laboratories Corporation Test kit for performing a medical test
US4647541A (en) * 1982-10-07 1987-03-03 Helena Laboratories Corporation Method for performing an occult blood test
US4447542A (en) * 1983-04-04 1984-05-08 Miles Laboratories, Inc. Analytical test composition, device and method for the determination of peroxidatively active substances
US4521520A (en) * 1983-04-07 1985-06-04 Smithkline Diagnostics, Inc. Method for in house occult blood testing
US5702913A (en) * 1983-12-21 1997-12-30 Helena Laboratories Corporation Chromgen-reagent test system
US5273888A (en) * 1984-01-16 1993-12-28 Helena Laboratories Corporation Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals
US4676950A (en) * 1984-02-03 1987-06-30 Foster Research Corporation Indicator and test device for detecting occult blood
US5081040A (en) * 1987-06-29 1992-01-14 Helena Laboratories Corporation Composition and kit for testing for occult blood in human and animal excretions, fluids, or tissue matrixes
US5217874A (en) * 1989-04-04 1993-06-08 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5196167A (en) * 1989-04-04 1993-03-23 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
JPH06148168A (en) * 1992-11-09 1994-05-27 Kyoto Daiichi Kagaku:Kk Composite for peroxide active material detection
US6850633B2 (en) * 2001-02-23 2005-02-01 Beckman Coulter, Inc. Devices and methods for reading and interpreting guaiac-based occult blood tests
US20100111763A1 (en) * 2008-03-18 2010-05-06 Kahn Laurence H Examination Device for Blood Detection
US7938776B2 (en) * 2008-03-18 2011-05-10 Mederistic Solutions, Inc. Examination device for blood detection
KR20160061911A (en) 2013-04-08 2016-06-01 데니스 엠. 브라운 Therapeutic benefit of suboptimally administered chemical compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838377A (en) * 1950-03-09 1958-06-10 Miles Lab Blood test
US2773906A (en) * 1953-05-06 1956-12-11 Monsanto Chemicals alpha, alpha-dialkyl-ar-phenylbenzyl hydroperoxides

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0222700A1 (en) * 1985-10-31 1987-05-20 Warner-Lambert Company Composition and method for determining peroxidase-like activity of hemoglobin
WO1992022669A1 (en) * 1991-06-19 1992-12-23 Hypoguard (Uk) Limited Reagent mixtures for glucose assay
WO2010079329A1 (en) 2009-01-08 2010-07-15 James Gordon Campbell Method and apparatus for alcohol concentration detection in a blood sample

Also Published As

Publication number Publication date
US3012976A (en) 1961-12-12

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