GB1057056A - Occult blood compositions using quinoline compounds for increased sensitivity - Google Patents

Occult blood compositions using quinoline compounds for increased sensitivity

Info

Publication number
GB1057056A
GB1057056A GB26150/64A GB2615064A GB1057056A GB 1057056 A GB1057056 A GB 1057056A GB 26150/64 A GB26150/64 A GB 26150/64A GB 2615064 A GB2615064 A GB 2615064A GB 1057056 A GB1057056 A GB 1057056A
Authority
GB
United Kingdom
Prior art keywords
indicator
hydroperoxide
specified
compositions
occult blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB26150/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of GB1057056A publication Critical patent/GB1057056A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/725—Haemoglobin using peroxidative activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Compositions for detecting occult blood in body fluids comprise an indicator the oxidation of which is catalysed by the prosthetic group of haemoglobin, an oxidising agent for the indicator and a potentiating agent of the formula:- <FORM:1057056/B1-B2/1> where R1 is H, CH3 or OH; R2 is H, CH3 or thiophenyl; R3 is H, CH3 or:- <FORM:1057056/B1-B2/2> R4 is H, CH3 or 0CH3; R5 is H or CH3; and R6 is H, CH3, OH or NH2. Specified indicators are o-tolidine, o-toluidine, p-toluidine, o-phenylenediamine, N:N1-dimethyl-p-phenylenediamine, p-anisidine, dianisidine, o-, m-, and p-cresols, a - and b -naphthols, catechol, guaiacol and pyrogallol. Specified oxidizing agents are inorganic and organic peroxides, namely hydroperoxide of cumene, p-menthane diisoproplybenzene and 2:5-dimethyl hexane. Specified potentiating agents include quinoline itself, quinine, cincholine and a number of other substituted quinolines. In the composition, the organic hydroperoxide is preferably in the form of encapsulated particles prepared in dispersion using gelatin, algin, carrageenin, casein or albumin and hardened by treatment with a dialdehyde polysaccharide as described in Specification 981,955. The procedure is described in detail. Other ingredients may comprise buffering systems (citrate, tartrate, phthalate, acetate, phosphate) giving a pH of 4-7 emulsifiers for the hydroperoxide (acacia mucilage, gum arabic, polyvinyl alcohol, carboxyvinyl polymer), surface active agents (sodium lauryl sulphate, dioctyl sodium sulphosuccinate, polyoxyethylenenonylphenol) which improve the evenness of application to carrier materials and solvents (chloroform, ethylene dichloride, ethyl acetate and benzene) for the indicator and potentiator. The compositions may be in the form of tablets, a mixture to be added to water, or impregnated on to bibulous materials e.g. paper or wood.
GB26150/64A 1963-06-24 1964-06-24 Occult blood compositions using quinoline compounds for increased sensitivity Expired GB1057056A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US290253A US3290117A (en) 1963-06-24 1963-06-24 Occult blood diagnostic composition with color enhancing agent

Publications (1)

Publication Number Publication Date
GB1057056A true GB1057056A (en) 1967-02-01

Family

ID=23115165

Family Applications (1)

Application Number Title Priority Date Filing Date
GB26150/64A Expired GB1057056A (en) 1963-06-24 1964-06-24 Occult blood compositions using quinoline compounds for increased sensitivity

Country Status (9)

Country Link
US (1) US3290117A (en)
BE (1) BE649682A (en)
BR (1) BR6460307D0 (en)
CH (1) CH446767A (en)
DE (1) DE1242905B (en)
DK (1) DK115507B (en)
GB (1) GB1057056A (en)
NL (2) NL6407185A (en)
SE (1) SE300717B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0043469A1 (en) * 1980-06-02 1982-01-13 Miles Laboratories, Inc. Interference-resistant test device for determining a peroxidatively active substance in a test sample and method for preparing it
WO1998056899A1 (en) * 1997-06-10 1998-12-17 Unilever N.V. Method for enhancing the activity of an enzyme, bleach composition, detergent composition and process for inhibiting dye transfer
CN113176253A (en) * 2021-04-21 2021-07-27 上海麦可信生物科技有限公司 Animal excrement occult blood indicator and application thereof

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3630847A (en) * 1967-07-20 1971-12-28 Boehringer Mannheim Gmbh Diagnostic agent for use in the determination of hydroperoxides and of peroxidate-active substances
DE2235152C2 (en) * 1972-07-18 1975-07-10 Boehringer Mannheim Gmbh, 6800 Mannheim Diagnostic agent for the detection of blood and other peroxidatically active substances in body fluids
DE2235127C2 (en) * 1972-07-18 1974-08-08 Boehringer Mannheim Gmbh, 6800 Mannheim Diagnostic agent for the detection of blood and other peroxidatically active substances in body fluids
CS175782B1 (en) * 1974-10-16 1977-05-31
CS176664B1 (en) * 1975-02-14 1977-06-30
US3986833A (en) * 1975-09-08 1976-10-19 Miles Laboratories, Inc. Test composition, device, and method for the detection of peroxidatively active substances
US4175923A (en) * 1978-06-26 1979-11-27 Friend William G Method and apparatus for occult blood testing in the home
US4189304A (en) * 1978-10-27 1980-02-19 Miles Laboratories, Inc. Device and method for detecting myoglobin
DE2905531A1 (en) * 1979-02-14 1981-01-08 Boehringer Mannheim Gmbh DIAGNOSTIC AGENT FOR DETECTING LEUCOCYTES IN BODY LIQUIDS
US4278439A (en) * 1979-12-17 1981-07-14 Miles Laboratories, Inc. Sensitizers for peroxidative activity tests
US4539180A (en) * 1980-09-24 1985-09-03 Regents Of The University Of Minnesota Apparatus for quantitatively determining the level of hemoglobin in a biological sample
US4526869A (en) * 1980-09-24 1985-07-02 Regents Of The University Of Minnesota Method for quantitatively determining the concentration of hemoglobin in a biological sample
US4378971A (en) * 1980-09-24 1983-04-05 Regents Of The University Of Minnesota Method and apparatus for quantitatively determining the level of hemoglobin in a biological sample
US4956300A (en) * 1982-01-05 1990-09-11 Helena Laboratories Corporation Aid for determining the presence of occult blood, method of making the aid, and method of using the aid
US5702913A (en) * 1983-12-21 1997-12-30 Helena Laboratories Corporation Chromgen-reagent test system
US5273888A (en) * 1984-01-16 1993-12-28 Helena Laboratories Corporation Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals
US4676950A (en) * 1984-02-03 1987-06-30 Foster Research Corporation Indicator and test device for detecting occult blood
DE3425219A1 (en) * 1984-07-09 1986-02-06 Boehringer Mannheim Gmbh, 6800 Mannheim USE OF ANILINE DERIVATIVES AS A CLUTCH COMPONENT IN OXIDATIVE COLOR FORMING REACTIONS
US4672029A (en) * 1984-12-06 1987-06-09 Eastman Kodak Company Color-forming couplers and their use in the analytical determination of hydrogen peroxide or other analytes
US4971914A (en) * 1984-12-11 1990-11-20 Litmus Concepts, Inc. Developer for fecal occult blood tests
US4939097A (en) * 1986-06-02 1990-07-03 Litmus Concepts, Inc. Fecal occult blood test methods
US5068197A (en) * 1984-12-11 1991-11-26 Litmus Concepts, Inc. Fecal occult blood test methods
DE3716891A1 (en) * 1987-05-20 1988-12-15 Boehringer Mannheim Gmbh TEST KIT FOR DETERMINING ANALYTIC IN THE CHAIR
US5081040A (en) * 1987-06-29 1992-01-14 Helena Laboratories Corporation Composition and kit for testing for occult blood in human and animal excretions, fluids, or tissue matrixes
US5310680A (en) * 1987-09-16 1994-05-10 Smithkline Diagnostics, Inc. Test for fecal occult blood
CA1322326C (en) * 1987-09-16 1993-09-21 Josefina Tecson Baker Test for fecal occult blood
US5053342A (en) * 1987-12-24 1991-10-01 Litmus Concepts, Inc. Fecal occult blood test reagents
US5217874A (en) * 1989-04-04 1993-06-08 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5196167A (en) * 1989-04-04 1993-03-23 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5447868A (en) * 1993-09-14 1995-09-05 Propper Manufacturing Co. Inc. Method, reagent and kit for the detection of fecal occult blood
US6850633B2 (en) * 2001-02-23 2005-02-01 Beckman Coulter, Inc. Devices and methods for reading and interpreting guaiac-based occult blood tests
GB0820817D0 (en) * 2008-11-13 2008-12-24 Wireless Biodevices Ltd Electrode, electrochemical sensor and apparatus, and methods for operating the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3012976A (en) * 1959-11-02 1961-12-12 Miles Lab Specific test composition for occult blood
NL277911A (en) * 1961-05-04

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0043469A1 (en) * 1980-06-02 1982-01-13 Miles Laboratories, Inc. Interference-resistant test device for determining a peroxidatively active substance in a test sample and method for preparing it
WO1998056899A1 (en) * 1997-06-10 1998-12-17 Unilever N.V. Method for enhancing the activity of an enzyme, bleach composition, detergent composition and process for inhibiting dye transfer
US6225275B1 (en) 1997-06-10 2001-05-01 Lever Brothers Company, Division Of Conopco, Inc. Method for enhancing the activity of an enzyme
CN113176253A (en) * 2021-04-21 2021-07-27 上海麦可信生物科技有限公司 Animal excrement occult blood indicator and application thereof

Also Published As

Publication number Publication date
NL6407185A (en) 1964-12-28
DE1242905B (en) 1967-06-22
BR6460307D0 (en) 1973-09-11
SE300717B (en) 1968-05-06
DK115507B (en) 1969-10-13
CH446767A (en) 1967-11-15
US3290117A (en) 1966-12-06
NL126365C (en)
BE649682A (en) 1964-10-16

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